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INDONESIA
Jurnal Farmasains
ISSN : 20863373     EISSN : 2620987X     DOI : -
Core Subject : Health,
Farmasains is a scientific publication for widespread research and criticism topics in pharmacy science studies. Farmasains is published twice a year in April and November since June 2010 by Department of Pharmacy University of Muhammadiyah Malang. One volume of Farmasains is published in two year calendar.
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Articles 53 Documents
FORMULASI SUSPENSI DOKSISIKLIN MENGGUNAKAN SUSPENDING AGENT PULVIS GUMMI ARABICI: UJI STABILITAS FISIK DAN DAYA ANTIBAKTERI Chasanah, Nur; Trisharyanti DK, Ika; Indrayudha, Peni
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 1, No 2 (2011): Oktober 2010 - Maret 2011
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (430.779 KB) | DOI: 10.22219/far.v1i2.1165

Abstract

Suspension is a dosage contain solid drug material with insoluble form and smooth. Doxycycline is an antibiotic which difficult dissolve in water. Stable doxycycline suspension during 2 week if it kept at space temperature, stable on the air but will change to be dark if it influence sunshine. The aim of the research to evaluate physical stability and ability antibacterial stability doxycycline suspension with PGA as suspending agent. Research category are: Independent variable : concentration of suspending agent (PGA), suspension holding time. Dependent variable: physical stability (sedimentation volume, viscosity, redispersibility, easy to pour, and particle size) and antibacterial of doxycycline suspension, and variabel control is temperature suspension making, create of suspension. Data collecting with measuring physical stability and ability antibacterial of doxycycline suspension. The result shows doxycycline suspension with suspending agent PGA had physical stability and antibacterial ability is good. Physical Stability test show  formula 1 rate PGA 5% is formula had physical stability better than formula 2 with rate PGA 7,5% and formula 3 withrate PGA 10%. stability ability test antibacterial show formula 2 is the  best in pursues Staphylococcus aureus.
STRUMA MULTI NODOSA NON TOKSIKA INTRATHORAKAL APA PILIHAN APPROACH OPERASINYA? HARUSKAH DILAKUKAN MEDIAN STERNOTOMY? Sander, Mochamad Aleq; CS, Fina
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 1, No 2 (2011): Oktober 2010 - Maret 2011
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.01 KB) | DOI: 10.22219/far.v1i2.1513

Abstract

Mochamad Aleq Sander, dr., M.Kes., SpB., FinaCSFakultas Kedokteran Universitas Muhammadiyah MalangJl. Bendungan Sutami 188A Malang 65145e-mail: aleq.sander@yahoo.comblog: bedahunmuh.wordpress.comAbstractIntrathoracal non toxic multi nodular struma is lumpy enlargement of thyroid glandwithout hypothyroidism that extend from cervical thyroid gland into thoracal cavity. Accordingto anatomy location of thyroid, their name were substernal, retrosternal, mediastinal,intrathoracal, plunging, anterior and posterior mediastinal, and aberrant mediastinal. Theorigin of blood supply of mediastinal struma was inferior thyroidea artery, especially casesfrom aorta, subclavia artery, internal mammary artery, or ima thyroidea artery. According toStudy got that seven patients with mediastinal struma had intrathoracal blood supply directly.Surgery could cervical approach and/or thoracotomy according to anatomic location andtype of intrathoracal struma.Keywords: intrathoracal strumaAbstrakStruma multi nodosa non toksika intratorakal adalah pembesaran kelenjar tiroid yang tampakberbenjol-benjol tanpa disertai tanda-tanda hipertiroidisme yang mengalami ekstensi kearahinferior dari kelenjar tiroid servikal hingga masuk ke dalam rongga thoraks. Jaringan tiroidyang berada di rongga toraks diberi nama sesuai tempat anatominya yaitu substernal, retrosternal,mediastinal, intrathorakal, plunging, anterior dan posterior mediastinum, serta mediastinumaberrant. Suplai darah untuk struma mediastinum biasanya dari arteri tiroidea inferior, padakasus tertentu suplai darah dapat berasal dari aorta, arteri subklavia, arteri mamaria interna,atau dari arteri tiroidea ima. Hasil penelitian didapatkan bahwa dari tujuh orang yang mengalamistruma mediastinum ternyata memiliki sumber perdarahan langsung dari intrathorakal. Tindakanoperasinya bisa melalui cervical approach dan/atau thoracotomy, hal ini tergantung dari lokasianatomis dan tipe struma intratorakal yang diderita oleh pasien.Kata kunci: struma intratorakal
PEMANFAATAN BIJI NIGELLA SATIVA DALAM TERAPI PENYEMBUHAN KANKER DAN GANGGUAN METABOLISME Jamil, Ahmad Shobrun
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 1, No 1 (2010): April-September 2010
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (58.354 KB) | DOI: 10.22219/far.v1i1.422

Abstract

The seed of Nigella sativa has long time ago employed as medicinal remedy for numerous disorders. N.sativa has active compounds in its seed likes nigellisine, nigellidine, nigellimine-N-oxide, thymoquinone, dithymoquinone, thymohydroquinon, nigellone, thymol, arvacrol, oxy-coumarin, 6-methoxycoumarin, 7-hydroxy-coumarin, alpha-hedrin, steryl-glucoside, flavonoids, tannins, essential amino acid, ascorbic acid, and minerals. The seed has various curative activities. As body immunity stimulator by stimulating the formations of bone marrow and many kind of antibody cells, antihistamine, anti-hypertension, anti-inflammation, antimicrobial activities by protecting bodies from viruses and decreasing the risk of infections, anti-diabetic (metabolic syndrome), and anti cancer. These papers have to discuss deeper about the beneficial aspect of N. sativa seed against metabolic syndrome and cancer. Based on several research known that N. sativa has potential to decrease total cholesterol, low density lipoprotein and blood glucose level. This seed also has potential to maintain the homeostatic of blood vessels as the backbone of the circulatory system in the body. At the cancer case, this seed substances has potential to decreasing the development of cancerous cells, kills the cells by enhances its apoptotic programs and also lessening the metastasis of the cancer cells. Keywords: cancer, metabolic syndrome, Nigella sativa
EFEK PEMACUAN APOPTOSIS FRAKSI ETIL ASETAT EKSTRAK ETANOL AKAR PASAK BUMI (EURYCOMA LONGIFOLIA JACK) TERHADAP SEL HELA Nurkhasan, Isnaniati Romadhoni Indarwati
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 2, No 1 (2012): Januari
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (504.549 KB) | DOI: 10.22219/far.v2i1.1151

Abstract

Pasak bumi is one of the Indonesian original plants having anticancer activity. Eurycomanone was isolated from Eurycoma longofolia, Jack  root was proven to have cytotoxic effect and induce apoptosis on Hela cells. The objective this study was to know the cytotoxic activity of ethyl acetate fraction of ethanolic extract of the Eurycoma longifolia, Jack root on Hela cells and the mode of death. Ethyl acetate fraction was obtained from  the ethyl acetate soluble fraction from residue of chloroform fraction of ethanolic extract of Eurycoma longifolia Jack roots. The cytotoxic assay was performed using MTT test method with concentration series used in this study were 1000; 750; 500; 400; 200; 100; 50; 12,5; 6,25; 3,125; and 1,5625 µg/ml. Absorbance was measured at wavelength of 550 nm using ELISA reader. Apoptosis assay were observed using Giemsa staining. MTT assay indicated that etil asetat fraction of ethanolic extract of the Eurycoma longofolia, Jack root showed cytotoxic activity againts Hela cells with IC50 value 3,70 µg/ml. The result of apoptosis assay indicated that the ethyl acetate fraction of ethanolic extract of the Eurycoma longofolia, Jack root induce apoptosis. The apoptotic cells was observed wrinkle, rounded and dark colors leading to chromatin condensation.
QUANTITATIVE STRUCTURE-CYTOTOXIC ACTIVITY RELATIONSHIP OF PHENYLTHIOUREA DERIVATIVES FROM CHEMBL DATABASE ON SIRTUIN-1 RECEPTOR BY IN SILICO Nasyanka, Anindi Lupita
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 4, No 1 (2019): April
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (822.876 KB) | DOI: 10.22219/farmasains.v4i1.7745

Abstract

Rational drug design becomes a necessity amid the development of drugs that are inefficient and time-consuming. Hansch's QSAR helps reduce these shortcomings supported by the role of biocomputation. Some of the roles of biocomputation that can be used include in silico testing and the availability of databases for new drug-receptor and ligand candidates. This study aims to determine the QSAR through the search for the best equations analyzed by ANOVA statistics between cytotoxic activity in silico (Log 1/c) anticancer compounds derived from phenylthiourea stored in the ChemBL database with lipophilic parameters (ALPP and AlogP) , electronic (ACDpKa), and its sterics (PMW). The best equation is obtained Log 1/c = -46,194 - 0,152 PMW- 3,769 ALogP - 1,336 ACDpKa with a value of N = 28; F = 20,866; r = 0,850;  P = 0,000; SE = 5.82160. In the future, this equation can be used to find other new phenylthiourea derivatives that have better cytotoxic activity.
ANTIBIOTIKA RASIONAL DALAM ILMU BEDAH Sander, Mochamad Aleq
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 2, No 1 (2012): Januari
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (163.161 KB) | DOI: 10.22219/far.v2i1.1160

Abstract

Utilizing of antibiotics to cure operation infection actually not differ from gift antibiotics in general. The difference was antibiotic treatment be addition therapy after surgery. The aim of antibiotics treatment was prevent or cure infection by reducing or eliminating bacteria until human body can handle this pathogenic organism.
PENGARUH IKLAN OBAT FLU DI TELEVISI TERHADAP PEMILIHAN OBAT SECARA SWAMEDIKASI PADA MASYARAKAT DI MALANG Rachmawati, Hidajah
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 1, No 2 (2011): Oktober 2010 - Maret 2011
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (451.333 KB) | DOI: 10.22219/far.v1i2.1169

Abstract

Communications is process transfer of information signing the forwarding of message of someone to others, either through indirect and also direct that is media.Television as a mass media technically capable of informing public in numerous amount in the same time. One of television program offering various product to fulfill requirement and satisfaction of physical is commercial. Such commercial is influenza drug commercial, because met many people. This matter of tendency make people to do self-medication as solving of from problem of health which they recognize by self.             Data collecting uses purposive sampling method in 102 respondents . Instrument test is done by validity test and reliability testing . Data analysis tool used is correlation analysis,t-test and regression analysis. Based on the result of the research, correlation coefficient is 0.645 so r table is 0,195, means there is a relation between influenza drug commercial and self-medication drug of choice. Based on the test t, t calculation is 2,376 so t table is 1,980, means there is influenza drug commercial in television has significant effect to self-medication drug of choice with equation regression Y = 4.803 + 0.522 x, means if influenza drug commercial in television indicator increasing 1 so self-medication drug of choice increasing 0.522. Value Sig. Of 0.000 <0.05 then the correlation coefficient deduced influenza drug commercial to self medication ?s drug of choice in people in Malang is significant.
PENGARUH SARI SEDUH TEH HITAM (CAMELIA SINENSIS) TERHADAP PENGHAMBATAN PPAR γ SEL ADIPOSA JARINGAN LEMAK VISERA RATTUS NORVEGICUS STRAIN WISTAR Herlina, Elan; ., Fatchiyah; Indra, Rasjad
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 1, No 1 (2010): April-September 2010
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1471.179 KB) | DOI: 10.22219/far.v1i1.426

Abstract

Penelitian bertujuan mengetahui pengaruh sari seduh teh hitam terhadap pengekspresian PPAR ã sel adiposa jaringan lemak visera Rattus norvegicus strain Wistar. Duabelas ekor tikus (Rattus norvegicus strain Wistar) jantan umur 6-8 minggu, berat 200 gram, diberi 4 macam perlakuan, yaitu A (diet tinggi lemak + SSTH 0 g/hari), B (diet tinggi lemak + SSTH 0,015 g/hari), C (diet tinggi lemak + SSTH 0,030 g/hari) dan D (diet tinggi lemak + SSTH 0,045 g/hari) selama 90 hari. Setelah masa perlakuan, tikus dibedah dan diambil lemak viseranya. Jaringan tersebut kemudian dibuat preparat dengan metode parafin. Jumlah sel yang mengekspresikan PPAR ã dianalisis dengan menggunakan pewarnaan immunohistokimia dan untuk mengkonfirmasi bentuk sel adiposa digunakan pewarnaan Hematoxylene&Eosin. Antibodi primer yang digunakan adalah anti PPAR gamma poliklonal antibody rabbit IgG dan antibodi sekunder biotin-goat-anti rabbit IgG. Hasil penelitian menunjukkan jumlah sel adiposa yang mengekspresikan PPAR ã mengalami penurunan seiring dengan penambahan dosis SSTH. Hal tersebut mengindikasikan SSTH dapat menurunkan pengekspresian PPAR ã pada sel adiposa jaringan lemak visera. Kata kunci: jaringan lemak visera, PPAR ã, diet tinggi lemak, sari seduh teh hitam
IN SILICO STUDY OF COX-2 ON INDOMETHACIN AND DICLOFENAC AS NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) Na'imah, Janatun
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 4, No 1 (2019): April
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1033.498 KB) | DOI: 10.22219/farmasains.v4i1.7767

Abstract

Cyclooxygenase is an enzyme that plays a role in the formation of prostaglandins, which can cause inflammation and pain when overexpressed. This study aims to determine the interaction between COX-2 macromolecules (receptors) with their ligands, namely indomethacin and diclofenac in silico using the Molecular Docking method. The COX-2 receptor was downloaded in the form of a 3D structure from the RCSB GDP with code 5F19. Diclofenac Ligand and Indomethacin were downloaded in the form of a 3D structure from the RCSB GDP with 4ZBQ code and 4IK7 code. The results showed that the interaction between COX-2 and indomethacin was the interaction of hydrogen, which linked indomethacin with amino acid Leu531 and steric interactions between indomethacin and amino acids Trp387, Tyr385, Tyr355, Leu352, and Val523. The interaction of [COX-2 ? Indomethacin] produces a value of ?G of -103.136 kcal/mol, and the value of RMSD is 1.244 Å. Whereas, the interaction that occurs in COX-2 with diclofenac is the steric interaction that happens between diclofenac with amino acids Leu390, Trp387, Gln203, His388, His207, and Thr206. The interaction parameter between [COX-2-Diclofenac] obtained ?G value of -7.843 kcal/mol and an RMSD value of 2.07851 Å. 
EFEK ATEROPROTEKTIF DAN VASOPROTEKTIF KATEKIN TEH HIJAU TERHADAP EKSPRESI ENOS PADA TIKUS WISTAR JANTAN DENGAN DIET TINGGI LEMAK Retty Ratnawati, Erna Susanti
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 2, No 1 (2012): Januari
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/far.v2i1.1155

Abstract

Catechins , isolate from green tea  GMB4 clones could be developed as a potential preventive agent for atherosclerosis. This activity is thought to be based on the structure epimerisation, hydroxy phenolic  and galloil group of these isolates. The purpose of this study is to prove the influence catechins ,isolate from green tea, on the inhibition of the decrease eNOS expression in male wistar rats induced by  high  fat diet. The method used in this study consisted of ELISA for measurement of eNOS expression. The results showed that  catechins inhibits the decreasing expression of eNOS at a dose of 6 mg / day and 24 mg / day was significantly but not dose 3mg / day. This suggests a dose 6mg / day and 24 mg / day is able to repair the damage signaling insulin on PI3K pathway caused by insulin resistance. These results are based on the ability of catechins as antioxidants. Catechins with hydroxy phenolic group  is a potential electron donor to bind  free radicals. Polyphenol catechins may also modulate  signaling cellular processes such as NFkâ, activator protein 1 DNA binding, glutathione biosynthesis, PI3K / Akt, MAPK pathway and the Nrf2 transcription factor that regulates expression of several antioxidant genes. It can be concluded catechins  inhibits  decreasing expression of eNOS  at a dose of 6 mg / day and 24 mg / day and can be developed as an agent and vasoprotective ateroprotective.