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Sainsmedika
ISSN : 20851545     EISSN : 2339093X     DOI : -
Core Subject : Health,
Sains Medika is journal of medicine and health, is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from Biomedical Sciences, Public Health, Clinical Sciences, and Medical Education to integrate researches in all aspects of human health. This journal publishes original articles, reviews article, and also interesting case reports.
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Articles 131 Documents
UTILIZATION OF ANTERIOR SEGMENT OPTICAL COHERENCE TOMOGRAPHY ENHANCED HIGH RESOLUTION CORNEAL IN MEASURING PTERYGIUM THICKNESS Hilmi, Mohd Radzi; Mohd Kamal, Khairidzan; Che Azemin, Mohd Zulfaezal; Esmady Ariffin, Azrin
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 9, No 2 (2018): July-Desember 2018
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (948.627 KB) | DOI: 10.30659/sainsmed.v9i2.2982

Abstract

Introduction: As various pterygium morphologies have been advocated as contributing factor on corneal astigmatism, little support in the literature available in establishing techniques in measuring pterygium thickness as clinical indicator.Objective: The aim of this study was to describe a quantitative method in determining pterygium thickness using anterior segment optical coherence tomography (AS-OCT).Methods: Anterior segment imaging was performed using enhanced high resolution cornea (EHRC) of Visante? AS-OCT in 120 primary pterygium eyes. Prior to imaging, corneal topography assessment was performed on each pterygium eye in order to identify its topographic location. Based on topography mapping, three meridians (in degrees) were selected as close as possible to the pterygium border, which signify the demarcation of pterygium from the cornea. Reliability testing between intra and inter-observer of AS-OCT imaging modality was examined using intraclass correlation and scatter plot.Results: The overall (n = 120) mean and standard deviation of pterygium thickness EHRC of AS-OCT modality were 0.48 ± 0.10 mm (confidence interval: 0.45 ? 0.50). EHRC of AS-OCT also showed excellent intra and intergrader reliability in measuring pterygium thickness with intraclass correlation of 0.997 (confidence interval: 0.994 ? 0.998).Conclusions: EHRC of AS-OCT imaging modality is a better choice in assessing pterygium compared to traditional slit-lamp biomicroscopy. This tool is applicable for future work related to better understanding on the role thickness in pterygium morphology, its progression and prediction of induced corneal astigmatism and visual impairment due to pterygium.
CORRELATION BETWEEN ATTITUDE OF MIDWIVE AND SUPPORT CADRE IN THE BEHAVIOR OF VITAMIN A POSTPARTUM MOTHER GIVING PRIMARY HEALTH CENTER KLATEN REGION Hasanah, Intan Nugraheni
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 5, No 2 (2013): July-December 2013
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (302.812 KB) | DOI: 10.26532/sainsmed.v5i2.351

Abstract

The Program to prevent vitamin A deficiency in Indonesia includes the administration of vitamin A for post partum mothers by giving a high dose ofvitamin A (@ 200,000 international standard). However, midwives sometimes do not evaluate and follow up the program implantation to make sure thatall postpartum women receive the capsule. This study was aimed at evaluating the midwivesâ?? attitude and health promotorsâ?? support and the behavior ofmidwives in giving the vitamin A capsule to post partum mothers in integrated health center (puskesmas) in Klaten regency. This was a cross-sectionalstudy among 37 midwives in puskesmas of Klaten. The data was obtained using a structured questionnaire. Univariate analysis used frequency distributionand bivariate using chi square test. Most of the respondents (75.6%) had a good supports (68%), there was a correlation between the attitude and behaviorof midwife in giving the vit A capsule (p=0.002). There was a correlation between the support of health promoters with the behavior of midwives in givingvitamin A capsule to post partum mothers(p=0.004). There was a correlation between the attitude and the behavior of midwife and support of healthpromotors and the behavior of midwives in giving the vitamin A to mother in Klaten regency.
OBESITY AS A RISK FACTOR FOR SURGICAL SITE INFECTION AFTER TRANSPERITONEAL CESAREAN SECTION Rahayu, Rahayu
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 9, No 1 (2018): January - June 2018
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1332.411 KB) | DOI: 10.26532/sainsmed.v9i1.1594

Abstract

Surgical site infection (SSI) is one of the main complications that can increase morbidity and mortality in obese women after cesarean section. Surgical site infection can be caused by endogenous or exogenous factors. This was a case of  a woman, G4P3A0, 32 years, after  trans-peritoneal cesarean section for indications of breech presentation; primary uterine inertia; premature rupture + 22 hours with BMI = 30.80 kg/m2. This case report discusses how obesity causes surgical site infection and its management.
SUCCESSFUL AGING Nasihun, Taufiqurrahman
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 6, No 1 (2015): January-June 2015
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (653.786 KB) | DOI: 10.26532/sainsmed.v6i1.334

Abstract

The emerging concept of successful aging is based on evidence that in healthy individual when they get aged, there are  considerable variations in physiological functions alteration. Some people exhibiting greater, but others very few or no age related alteration. The first is called poor aging and the later is called successful pattern of aging (Lambert SW, 2008). Thus, in the simple words the successful aging concept is define as an opportunity of old people to stay  active and productive condition despite they get aged chronologically. Aging itself might be defined as the progressive accumulation of changes with time associated with or responsible for the ever-increasing susceptibility to disease and death which accompanies advancing age (Harman D, 1981). The time needed to accumulate changes is attributable to aging process. The marked emerging questions are how does aging happen and where does aging start?To answer these questions and because of the complexity of aging process, there are more than 300 aging theories have been proposed to explain how and where aging occured and started respectively. There are too many to enumerate theories and classification of aging process. In summary, all of these aging theories can be grouped into three clusters: 1. Genetics program theory, this theory suggests that aging is resulted from program directed by the genes; 2. Epigenetic theory, in these theory aging is resulted from environmental random events not determined by the genes; 3. Evolutionary theory, which propose that aging is a medium for disposal mortal soma in order to avoid competition between organism and their progeny for food and space, did not try to explain how aging occur, but possibly answer why aging occur (De la Fuente. 2009). Among the three groups of aging theories, the epigenetic theory is useful to explain and try to solve the enigma of aging which is prominently caused by internal and external environmental influences.There are gradual decline of physiological functions in human after becoming adult in life. The declining of physiological functions might be define as decrease in protein synthesis capacity, bone mineral density, immunological function, strength and muscle mass, and otherwise increase in fat accumulation (Rudman D, et al. 1982; Charmpilas N, et al. 2015). Epidemiologic study indicated that the predominant cause of morbidity, mortality, and reduced longevity in cohort were acute and chronic inflammatory as well as oxidative stress, resulted from environmental inflammations, infections, obesity, and social distress. Acute inflammatory is commonly caused by biological agent, especially both or either bacterial and or viral, whereas chronic inflammatory is related to environmental inflammagen, obesity, and social distress (Sone H et al. 2010) Chronic oxidative stress injures cells particularly in regulatory sytem such as endocrine, nervous, immune, and the neuro-endocrine immune communication by wich cell loss its homeostasis regulatory and cannot preserve health (De la Fuente. 2009). Subsequently, it will impaire homeostasis that leads to an increase in the morbidity and mortality of aging. Likely, answer to the question of where aging start is from the mitochondrial cells of regulatory system. Various evidences indicate that the rate of mitochondrial oxygen radical generation, the degree of membrane fatty acid unsaturation, and oxidative damage to mitochodrial DNA are lower in the long-live species compared to short live species (Braja G, 2004). Several studies also indicate that majority of human adults die due to complication of atherosclerosis, cancer, dimentia, whereas in healthy age  invariably accompanied by muscle weakness, and make them frail, disabled, and dependent before eventually died. Such disability prominently caused by skeletal muscle weakness due to diminution of muscle mass and its nerve, osteoarthrirtis, and others chronic degenerative diseases related to oxidative stress (Payton OD, et al. 2012) Furthermore, physical weakness in aging people, generally marked by imbalanced, immobility, low durability, and physical frailty. Consequences of such physical frailty are easy to fall, bone fracture, dependence, hence decreasing daily activity (Buchner DM, et al. 1992; Lambert SW, 2008)To ameliorate the impairment of homeostasis, a caloric restriction but not malnutrition diet and adequate exercise (aerobic, resistance, and streching) can be adopted to neutralize as part of the oxidative and inflammatory stress and to strengthen and increase muscle mass (Payton OD, et al. 2012; Park S, et al. 2012). In special individual condition, like as overweight or obesity, smoker and frequently use of mobile phone, proper antioxidant supplementation can be considered. In addition, caloric restriction, food intake is intentionally reduced by 30â??50% has been shown to delay the aging process in mice by decreasing the levels of histone deacetylase2 (HDAC2), which other wise increases during the normal aging process (Mercken EM, et al. 2012).
IN VITRO EFFECT OF ALFA MANGOSTIN ON MULTIRESISTANT UROPATHOGENIC ESCHERICHIA COLI Rakhmawatie, Maya Dian; Rohmani, Afiana; Ahyar, Fariz Wafaul
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 1 (2017): January - June 2017
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (761.141 KB) | DOI: 10.26532/sainsmed.v8i1.1002

Abstract

Introduction: In Indonesia, the most commom uropatogen E. coli resistance has been to ampicillin (91.9%), ciprof loxacin (83.7%) and cefixime (67.6%). ?-mangostin, a chemical compound, has been developed as a new antibiotics isolaated from herbal Garcinia mangostana L, but its effectiveness against multiresistant uropathogenic E. Coli has not been established.Objective: This study examined the effect of ?-mangostin on growth of multiresistant E. coliMethods: ?-mangostin Treatment of E. coli uropatogen bacteria was administered in vitro, using 14 levels of concentration 14; 28,13; 56.25; 112.5;225; And 450 ?g/mL with 4 times replication at each concentration. The antibacterial activity of ?-mangostin was determined by evaluating bacterial growth at each concentration using the indirect method by sample absorbance reading. The Samples of uropatogen of E. coli treated with various doses of ?-mangostin were incubated for 18-20 hours and then subjected to the absorbance reading using a UV-Vis spectrophotometer ? 625 nm.Results: Minimum inhibitory concentration (MIC) in this study was 450 mg/mL. Based on linear regression (STATA 13.1) relationship between?-mangostin concentrations and bacterial growth inhibition activity showed 0.0001 <0.05 showing that all concentrations of ?-mangostin simultaneously had a significant effect on the growth of uropathogenic E. coli.Conclusion: ?-mangostin has not been effective to inhibit the growth of multiresistent uropathogentic E. coli due to a relatively high MIC (450 mcg/mL).a Potentially relevant activity in the clinical setting will occur if the value of the MIC of a substance in vitro <100 ?g /mL. Even the pharmaceutical industry prefers the development of antibiotics with in vitro MIC value of ? 2 ?g/mL.
CALORIE RESTRICTION, STEM CELLS, AND REJUVENATION APPROACH Nasihun, Taufiqurrachman
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 7, No 2 (2016): July-December 2016
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (138.331 KB) | DOI: 10.26532/sainsmed.v7i2.1171

Abstract

Aging may be defined as the time-dependent deterioration in function of an organism associated with or responsible for the increase in susceptibility to disease and probability of death with advancing age (Harman, 1981; Cefalu, 2011). Generally, the aging organisms are characterized by both biochemical and functional declines. Declining of basal metabolism rates, protein turnover, glucose tolerance, reproductive capacity, telomere shortening, and oxidative phosphorylation are related to the biochemical. Whilst, lung expansion volume, renal glomerular and tubular capacities, cardiovascular performance, musculoskeletal system, nerve conduction velocity, endocrine and exocrine systems, immunological defenses, and sensory systems are associated with the physiological declining (Baynes and Dominiczak, 2015). Some evidences indicated that, although members of a species develop into adults in the same way, even genetically similar or identical individuals, raised in identical conditions and eating identical food, but they may age differently (Baynes and Dominiczak, 2015). These aging differences are attributable to the life style particularly calorie and dietary restriction intakes, reactive oxygen species (ROS) production, and thus its implication on severity of damage, repair capacity, and error accumulation in cellular genetic material (Baynes and Dominiczak, 2015; Mihaylova et al., 2014; Mazzoccoli et al., 2014). Therefore, in molecular terms, aging can be defined as a decline of the homeostatic mechanisms that ensure the function of cells, tissues, and organs systems (Mazzoccoli et al., 2014). Accordingly, if the homeostatic mechanism can be repaired, the result is rejuvenation.
DIAGNOSTIC STUDY ON IDENTIFICATION METHOD OF ENTEROBACTERIACEAE DIRECTLY FROM BLOOD CULTURE Ciptaningtyas, V. Rizke; Hapsari, Rebriarina; Kristina, Tri Nur; Winarto, Winarto
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 6, No 2 (2015): July-December 2015
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (360.744 KB) | DOI: 10.26532/sainsmed.v6i2.599

Abstract

Introduction: The provision of rapid diagnosis results from positive blood cultures is important for clinical management of sepsis. Using conventional method as a reference method in laboratory, time needed for bacterial identification are 24 hours longer because it has to deal with primary isolation step. Objectives: This study investigated the accuracy of direct inoculation technique of bacteria from positive blood culture vials to biochemical test tubes without primary isolation step to identify Enterobacteriaceae, second most common causative agent of sepsis.Methods: The study was conducted at the Microbiology Laboratory Medical Faculty of Diponegoro University. This is a diagnostic study. As the study sample, blood cultures in BACTEC bottles from Dr. Kariadi General Hospital Semarang with bacterial growth in it. Inclusion criteria was Gram-negative rod bacteri, staining results from BACTEC blood culture bottles, and as a exclusion criteria, there are more than one colony found on blood agar and Mac Conkey agar and showed positive result in oxidation test. Identification of bacteria based on biochemical table of Enterobacteriaceae. Data were analyzed with a 2x2 table.Results: Thirty two samples included in this study. Ten samples (31%) were excluded. Twenty one from twenty two (95%) study samples accurately identified to the genus level by direct inoculation method.Conclusion: The results showed that the direct inoculation method provides an acceptable genus identification, with a potential saving of 24 hours compared with conventional methods.
THE BEHAVIORAL FACTOR ASSOCIATED WITH THE INCIDENCE OF MALARIAIN ENDEMIC AREA Zulaikhah, Siti Thomas; Etika, Dhanny Rona; Mashoedi, Imam Djamaludin
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 3, No 2 (2011): Juli-Desember 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (155.943 KB) | DOI: 10.26532/sainsmed.v3i2.400

Abstract

Background: Magelang Regency is one of the endemic area of malaria in central Java. The working area of Health centre of Kajoran I, Banjaretno, has the highest incidence of malaria annually (Dinkes Magelang, 2010). Malaria is is transmitted through the bite of female Anopheles infected by Plasmodium sp. Its most effective prevention is vector eradication. This study was aimed at finding out the behavioral risk for the incidence of malaria.Design and Methods: In this observasional study using case control design include 40 cases and 40 controls using the simple random sampling. Chi square test followed by double-logistic regression was applied for the data analysis with p=5%. Results: Bivariate analysis on the 6 factors resulted in p<0.05 and 2 factors resulted in p>0.05. multivariate analysis showed that the habit factor of going out in the evening, installing wire gauze on the ventilation, hanging used clothes, mowing lawn, the existence of closed waste basket, washing the curtain resulted in the p=0.010 (OR = 10; 95% CI = 3.4-39.2), p=0.001 (OR = 4.1; 95% CI = 3.5-15.8), p=0.018 (OR = 3.3; 95% CI = 1.9 -16.2), p=0.044 (OR = 6.5; 95% CI = 2.1-30.9), p=0.380 (OR = 0.43; 95% CI = 0.1-1.2), p=0.002 (OR = 2.4; 95% CI =3.4 -5.6) respectively.Conclusion: The habit of going out in the evening has been shown to be most important behavioral factor associated with the malaria incidence (Sains Medika, 3(2):168-184).
THE CORRELATION OF EXERCISE AND RANGE OF MOTION (ROM) ON ELDERLY KNEE OBSERVASIONAL STUDY ON ELDERLY PEOPLE IN PEDURUNGAN SEMARANG Widyantoro, Adhitya Putra; Rosdiana, Ika; Fasitasari, Minidian
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 1 (2012): Januari-Juni 2012
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (139.675 KB) | DOI: 10.26532/sainsmed.v4i1.383

Abstract

Background: In aging process, decreasing of musculosceletal capabilities will reduce physical activity and excercise, as well as Range Of Motion (ROM). In order to maintain the normality of ROM, joints and muscles should be moved regularly. However many elderly people are still less physically active, due to lack of knowledge, no free time for physical activity, and lack of support from the social environment. This study aimed to determine the correlation of excercise on ROM of knee in the elderly in Pedurungan District, Semarang.Design and Method: Observastional study with a cross sectional design 80 elderly men and women were divided into 2 groups: gymnastics group in the Social Rehabilitation Unit Of Pucang Gading (n=40) and unexcercises group in the Penggaron village (n=40). In both groups, the degree of ROM of knee was assessed using the Goniometer. To evaluate the value of its significance, the data were analyzed using the Mann Withney test followed by Spearmannâ??s rho test.Result: ROM for gymnastic(exercised group) and unexercised group were 115.50°±11.591°, 95.38°±12.780° respectively with p<0. 001. Resuts showed that doing exercise was useful for maintaining ROM of knee in elderly people. Spearmannâ??s rho test resulted in a strong correlation between ROM and exercise with r value of 0.652.Conclusion: exercise correlates with ROM of knee in elderly (Sains Medika, 4(1):39-45).
MAHKOTA DEWA MESOCARP INFUSION IMPROVED TESTICULAR DAMAGE AND SPERM COUNT IN DIABETIC RAT Sulistyoningrum, Evy; Setiawati, Setiawati; Nindyastuti, Herlina; Putra, Adrian Nugraha
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 2 (2012): Juli-Desember 2012
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (578.807 KB) | DOI: 10.26532/sainsmed.v4i2.367

Abstract

Background: Global prevalence of Diabetes Mellitus (DM) is predicted to be increasing with worldwide population increase, longer life expectancy, urbanization, change in lifestyle and higher incidence of obesity. Diabetes Mellitus which is characterized by increasing level of blood glucose can induce increasing activity of ROS (Reactive Oxygen Species) which can further lead to abnormality in male reproductive system, especially testis. Mahkota dewa (Phaleria macrocarpa (Scheff.) Boerl.=PM) contain flavonoid, alkaloid and saponin which can prevent further negative effect on ROS increase in male reproductive system. The aim of this study was to know effect of PM mesocarp infusion on testicular damage and sperm count in alloxan induced diabetic rat.Design and Method: The design of this study was post test only with control group design. Rats in this study were divided into 4 groups (6 rats each group): control group, diabetic group, diabetic group treated with PM mesocarp infusion (9% and 13.5%). Diabetes was induced by alloxan 50 mg/BW single dose injection intramuscularly. PM mesocarpâ??s infusion was given in 4 weeks. Testicular damage was observed in hematoxylin-eosin stain using Johnsen criteria for spermatogenesis level and tubulus seminiferousâ?? diameter. Sperm count was performed on the semen taken from vas defferens using Giemsa stain.Result: PM mesocarp infusion group has higher spermatogenic level (p < 0,05), higher tubulus seminiferus diameter and sperm count (p < 0,05) than diabetic group.Conclusion: Mahkota dewa mesocarp infusion improved testicular damage and sperm count in alloxan-induced diabetic rat (Sains Medika, 4(2):115-123).

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