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International Journal of Integrated Health Sciences
ISSN : 23021381     EISSN : 23384506     DOI : -
Core Subject : Health,
International Journal of Integrated Health Sciences (IJIHS) is a peer-review journal which publishes original articles, medical research, clinical research and case report. This journal is supported by Faculty of Medicine Universitas Padjadjaran and was launched on September 22nd 2012 and firstly published on July 2013. The first and second publications in 2013 and 2014 were published annually. In 2015 IJIHS published twice in a year, March and September.
Arjuna Subject : -
Articles 88 Documents
EFFECTS OF CORE STRENGTH TRAINING USING STABLE VERSUS UNSTABLE SURFACES ON LOWER BODY QUALITY IN 8TH GRADE MALE AND FEMALE STUDENTS IN A JUNIOR HIGH SCHOOL IN BANDUNG Dwidarti, Sitti Juhana; Prabowo, Tertianto; Sungkar, Ellyana
International Journal of Integrated Health Sciences Vol 6, No 1 (2018)
Publisher : International Journal of Integrated Health Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v6n1.1050

Abstract

Objective: To investigate the effects of core strength training performed on stable (CSTS) compared to unstable surfaces (CSTU) on physical fitness in school-aged boys and girls.Methods: In this study, 72 (36 males, 36 females) untrained healthy subjects (mean age: 14±1 years, age range: 13?15 years) were randomly assigned to a CSTS group for stable surface (n = 36; 18 males and 18 females) or a CSTU group for unstable surface (n = 36; 18 males and 18 females). Core strength training performed on stable as compared to unstable surfaces were assessed on pre- and post-tests. Training period lasted 6 weeks (2 sessions/week). The components of physical fitness were assessed using standing long jump test,  stand-and-reach  test,  20-m  sprint  test, jumping  sideway test, and y balance  test.   Results: This study showed significant results in increased components of physical fitness in both CSTS and CSTU groups (p<0.05). The increase of physical fitness for CSTU was better than CSTS (p<0.05). There were differences of physical fitness between gender in both groups (p<0.05) except for stand-and-reach test (p>0.05).Conclusion: Core strength training performed on unstable and stable surfaces increases all components of physical fitness in youths. Core strength training performed on unstable surface can better improve the physical fitness compared to the stable surface. There were differences of physical fitness between gender in both groups except for stand-and-reach test.Keywords: Resistance training, physical fitness, gender DOI: 10.15850/ijihs.v6n1.1050
AKT–THE MAMMALIAN TARGET OF RAPAMYCIN (MTOR) PATHWAY INHIBITION INCREASES CERVICAL CANCER CELL CHEMOSENSITIVITY TO ACTIVE FORM OF IRINOTECAN (SN-38) Septiani, Leri; Hidayat, Yudi Mulyana; Effendi, Yusuf Sulaeman; Djuwantono, Tono; Luftimas, Dimas Erlangga; Faried, Ahmad
International Journal of Integrated Health Sciences Vol 1, No 1 (2013)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To investigate the molecular pathway of the cytotoxic effect of SN-38 in human cervical cancer cell lines.Methods: Two human cervical cancer cell lines were treated with various concentrations of irinotecan for 24?72 hours and the sensitivity was analysed using the MTT assay. Apoptosis was further observed through microscopic examinations. The protein expression was determined using Western blot analysis.  Results: CaSki cells demonstrated the highest sensitivity to SN-38, whereas HeLa cells showed the lowest. In cervical cancer cells, SN-38 induced apoptosis through an intrinsic- and extrinsic-pathways. In addition, we showed that SN-38 downregulated the phosphorylation of Akt-mTOR pathways in CaSki cells, but not in HeLa cells. Interestingly, in HeLa cells, which were more suggestive of a resistant phenotype, pre-treatment with LY294002 and rapamycin inhibited activation of Akt-mTOR signaling and significantly enhanced the sensitivity of HeLa cells to SN-38. Conclusions: Irinotecan exerts its anti-neoplastic effects on cervical cancer cells by inducing apoptosis through caspase-cascade. Inhibition of Akt-mTOR, LY294002 and rapamycin, which is targeted to Akt-mTOR pathways, may sensitize irinotecan-resistant cervical cancer cells.Keywords: Akt-mTOR pathways anti-neoplastic drugs, cervix cancer cells, LY294002, rapamycin DOI: 10.15850/ijihs.v1n1.103
RELATIONSHIP OF PROSTATE-URETHRAL ANGLE AND INTRAVESICAL PROSTATIC PRTUSION WITH INTERNATIONAL PROSTATIC SYMPTOMS SCORE AND UROFLOWMETRY IN BENIGN PROSTATIC HYPERPLASIA PATIENTS Tjahjodjati, Tjahjodjati; Santoso, Jumadi
International Journal of Integrated Health Sciences Vol 3, No 2 (2015)
Publisher : International Journal of Integrated Health Sciences

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Objective: To investigate the correlation between Intravesical Prostatic Protrusion (IPP) and Prostate Uretral Angle (PUA) in Benign Prostatic Hyperplasia (BPH) patient with Lower Urinary Tract Symptoms (LUTS) on International Prostatic Symptoms Score (IPSS) and uroflowmetry.Methods: A cross sectional study was done to 71 BPH patients with LUTS who attended Urologic Clinic in Dr. Hasan Sadikin General Hospital and matched the inclusion and exclusion criterias. The Intravesical Prostatic Protrusion and PUA were measured using transrectal ultrasound and the degree of LUTS was measured using IPSS and uroflowmetry. Patients were classified based on PUA (<350 dan ?350) and degree of IPP (grade 1< 5mm;II 5-10mm;III >10mm). Data were analyzed using Spearman correlation test. Results: Prostatic-Urethral Angle has a strong correlation with IPSS total and voiding (0.670 and 0.715) but the correlation was weak with IPPS storage (0.381). Furthermore, PUA has a strong negative correlation with Qmax dan Qave values. The bigger the PUA, the smaller Qmax dan Qave values. IPP has a strong correlation with IPSS total and voiding (0.645 and 0.662), but has moderate correlation with IPSS storage (0.442). Furthermore, IPP has no correlation with the values of Qmax, Qave, Voided volume and PVR.Conclusions: Prostatic-Urethral Angle and Intravesical Prostatic Protrusion have a strong correlation with the occurence of LUTS in BPH patients. Keywords: Benign prostatic hyperplasia, intravesical prostatic protrusion, lower urinary tract symptoms, prostate-urethral angle DOI: 10.15850/ijihs.v3n2.583
ROLE OF RISK FACTORS IN THE INCIDENCE OF MULTIDRUG-RESISTANT TUBERCULOSIS Khairani, Alya Putri; Santoso, Prayudi; Setiawati, Elsa Pudji
International Journal of Integrated Health Sciences Vol 5, No 2 (2017)
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Objective: To determine the risk factors that played roles in the incidence of multidrug-resistant tuberculosis (MDR-TB) in such patients. Multidrug-Resistant Tuberculosis is a form of tuberculosis caused by Mycobacterium tuberculosis that is resistant to at least isoniazid and rifampicin.Methods: This was a case control study to compare MDR-TB to non-MDR-TB pulmonary tuberculosis outpatients in Dr. Hasan Sadikin General Hospital, Bandung on August?September 2014. Fifty MDR-TB outpatients were included as the cases and 50 non-MDR-TB outpatients as controls. Data was collected by questionnaires and patient?s registration forms. Bivariate and multivariate analyses were performed using chi-square test and multiple logistic regression test, with p<0.05 considered significant. Results: From bivariate analysis, number of previous tuberculosis treatments, regularity of previous treatment, and burden of cost were significant risk factors for developing MDR-TB (p<0.05); while from multivariate analysis, number of previous TB treatments was the only risk factor that played a significant role in the incidence of MDR-TB (OR 24.128 95% CI 6.771-85,976). Conclusions: Patients and medication factors are risk factors that play roles in the incidence of MDR-TB. The significant risk factor is the number of previous TB treatment. Keywords: Multidrug-resistant tuberculosis, resistance, risk factors, tuberculosis DOI: 10.15850/ijihs.v5n2.991
PREDICTION OF JAMAR GRIP STRENGTH VALUE USING MODIFIED ANEROID SPYHGMOMANOMETER CUFF METHOD Pujianita, Lusia; Prabowo, Tertianto; Prananta, Marietta Shanti
International Journal of Integrated Health Sciences Vol 5, No 1 (2017)
Publisher : International Journal of Integrated Health Sciences

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Objective: To examine the prediction of Jamar grip strength value by using aneroid sphygmomanometer cuff method in adults.Methods: This study involved 120 subjects, aged 20?59 years old. The grip strength of subjects were measured using Jamar dynamometer and aneroid sphygmomanometer cuff method. Spearman analysis was used to evaluate the correlation between variables and grip strength. Forward stepwise was used to analyze the regression of Jamar dynamometer using aneroid sphygmomanometer cuff method. Results: There was a weak correlation (r<0.4) between grip strength with age and BMI, moderate correlation (r = 0.4?0.6) for grip circumference, and also strong correlation r= (0.6?0.8) for sex, hand length, and hand width. Jamar grip strength value can be predicted using spyghmomanometer with the formula of (0.1157 x Sphygmomanometer grip strength value) ? (5.696 x sex) + (0.0824 x age) (female =1, male= 0).Conclusions: Grip strength correlates with physiological variables. The variables to predict Jamar grip strength using sphygmomanometer are sex and age. Regression analysis shows that spyhgmomanometer can be used as an alternative to measure grip strength and has a valid value to predict the Jamar grip strength value. Keywords: Adult, grip strength, Jamar dynamometer, sphygmomanometer, prediction formula DOI: 10.15850/ijihs.v5n1.958
EICOSAPENTAENOIC ACID AS ADJUVANT FOR CACHEXIA IN CANCER’S PATIENTS Hadi, Soeseno; Kurniawan, Cynthia; Budiono, Jansen
International Journal of Integrated Health Sciences Vol 3, No 1 (2015)
Publisher : International Journal of Integrated Health Sciences

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Cachexia is a frequent problem in cancer patients associated with mortality and morbidity since it causes death, reduced therapy effectiveness, as well as decreased quality of life. Cachexia emerges from interactions of several factors, namely metabolic effect of cancer cells, factors released by cancer cells, cytokines release from host cell in response to tumors, and side effects of therapies. Combination of these factors contributes to anorexia, decreased body fat and muscle, and weight loss. Unfortunately, there is no gold standard for treatment of cachexia. Several studies found that eicosapentaenoic acid (EPA) might improve cancer cachexia. It has potential blocking effects on several cachexia underlying factors. It may reverse weight loss, increase lean body mass, and improve the efficacy of therapy and the quality of life. The objective of this literature review is to describe and give basic understanding of EPA as adjuvant for cancer cachexia. Keywords: Cachexia, cancer, EPADOI: 10.15850/ijihs.v3n1.399
PATTERN OF PROSTATE SPECIFIC ANTIGEN AND GLEASON SCORE IN RELATION TO IMUNOHISTOCHEMISTRY FEATURES IN PROSTATE ADENOCARCINOMA PATIENTS IN DR. HASAN SADIKIN GENERAL HOSPITAL Glady, Azela; Hamidah, Endah; Prasetyo, Rahmat Budi; Sutiono, Agung Budi
International Journal of Integrated Health Sciences Vol 4, No 1 (2016)
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Objective: To review the correlation between prostate specific antigen (PSA) and Gleason score and Cav-1 for diagnosing prostate adenocarcinoma.Methods: Data were collected from one hundred fifty-nine patients with prostate adenocarcinoma at the Department of Urology, Dr. Hasan Sadikin General Hospital in the period of January 2008?December 2010. The PSA levels were measured and classified into <4 ng/ml, 4?10 ng/ml, and >10 ng/ml. The results were then analyzed and compared to the imunohistochemistry (caveolin-1) staining in the literature. The Gleason score was also noted and analyzed. Results: This study confirmed that positive caveolin-1 expression was related to the clinical markers of disease progression and was predictive of poor clinical outcome after surgery. The PSA results showed that one hundred fourty-one adenocarcinoma patients had a PSA level of >10 ng/ml with Gleason score of gleason 5?6 as the most common score. However, there was no correlation between PSA and Gleason score and caveolin-1 for diagnosing prostate adenocarcinoma.Conclusions: Caveolin-1 cannot be used to measure Gleason and PSA score due to different markers that have various advantages and disadvantages to predict carcinoma prostate. Therefore, further studies are needed. Keywords: Gleason score, imunohistochemistry, prostate adenocarcinoma, prostate specific antigen DOI: 10.15850/ijihs.v4n1.679
KNEE EXTENSOR STRENGTH PREDICTION FORMULA USING MODIFIED ANEROID SPHYGMOMANOMETER IN HEALTHY FEMALE ADULTS Setiawan, Erik; Prananta, Marietta Shanti; Novitri, Novitri
International Journal of Integrated Health Sciences Vol 6, No 1 (2018)
Publisher : International Journal of Integrated Health Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v6n1.1103

Abstract

Objective: To discover isometric knee extensor muscle strength prediction formula using hand-held dynamometer (HHD) through the use of modified aneroid sphygmomanometer (MAS). Isometric knee extensor muscle strength examination is required to diagnose and evaluate the treatment of quadriceps femoris weakness.Methods: This was a quantitative observational and correlational analysis study with cross-sectional design. Isometric knee extensor muscle strength was measured using HHD and MAS with 60o knee flexion in sitting position. Correlation tests were performed to investigate the correlation between HHD, MAS, and other variables. Regression test was carried out to analyze knee extensor strength regression using HHD through MAS.Results: TSubjects enrolled were 25 healthy females aged 23?52 years old. The correlation between HHD and MAS was significant while age, body weight, body height, and body mass index (BMI) did not show correlation with HHD and MAS. The isometric knee extensor muscle strength using HHD could be predicted by formula = 0.1041xMAS.Conclusions: Isometric knee extensor muscle strength measured using HHD strongly correlates with that of using MAS with 60o knee flexion in sitting position and can be predicted from measurement values of MAS. The formula is only suitable for females.Keywords: Hand-held dynamometer, knee extensor, prediction formula, sphygmomanometer DOI: 10.15850/ijihs.v6n1.1103 
NEPHROPATHY AND ENCEPHALOPATHY IN AN INDONESIAN PATIENT WITH DENGUE VIRAL INFECTION Rachmadi, Dedi; Anggara, Mohamad Yanuar
International Journal of Integrated Health Sciences Vol 1, No 1 (2013)
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Objective: To describe unusual manifestation of dengue virus infection that has been increasing in number and elucidate the indirect effect of dengue infection on the central nervous system which may explain the occurence of dengue encephalopathy. Methods: A case report of 6-year-old boy who was admitted with a history of fever for three days, accompanied with decreased consciousness, hypertension, and edema is presented. Laboratory examination showed hemoconcentration, thrombocytopenia, with positive anti dengue Immunoglobulin G (IgG) and IgM, microscopic glomerular hematuria, and proteinuria as well as normal creatinine serum level. He was treated with supportive treatment. Results: After six days, the consciousness was improved and blood pressure was normal.  Proteinuia was alleviated by Day 11 and completely negative on Day 19.  Microscopic glomerular hematuria was negative after 6 months.Conclusions: Recognition of unusual dengue manifestations is important in early diagnosis and effective treatment of the disease.Keywords: Dengue virus infection, encephalopathy, nephropathy DOI: 10.15850/ijihs.v1n1.108
PENETRATING WOUND IN THE SKULL BY A SHARP METAL OBJECT Faried, Ahmad; Saputra, Priandana Adya Eka; Yudoyono, Farid; Arifin, Muhammad Zafrullah
International Journal of Integrated Health Sciences Vol 3, No 2 (2015)
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Objective: Penetrating skull injury (PSI) is a neurosurgical emergencies. Most PSI cases reported were caused by gunshot wounds. Although the diagnosis and management of those cases has been described, the actual cases, especially in our center, were quite rare.Methods: A craniectomy debridement with a supine position was performed and removal of the object was achieved. Intraoperatively, we succed control the bleeding as expected.Results: The patient was operated and hospitalized in our center; physical examination revealed neurologically intact before and after the removal of the object. The patient was sent home without any neurological deficits or other complications.Conclusions: We reported a case of penetrating skull injury in a 5-year-old girl caused by a scissors. Penetrating skull injuries were interesting due to its mechanism, management and complications. Early diagnosis and appropriate treatment should resulted in good outcomes.Keywords: Penetrating skull injury, a sharp metal object DOI: 10.15850/ijihs.v3n2.588