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Articles 4 Documents
Search results for , issue " Vol 23, No 03 (1991)" : 4 Documents clear
The management of hyperlipidemia Ahmad H. Asdie, Ahmad H. Asdie
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 23, No 03 (1991)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

In terest in hyperlipidemia is related to its role in atherogenesis. The connection between bloodcholesterollevels and varibus manifestations of coronary heart disease has long been apparent.However, proof that this connecton is causal has been more elusive. For particular subpopulations it has been demonstrated that lowering elevated cholesterol levels can lead to fewer coronary heart disease events; this provides strong evidence of a causal relationship which can furthermore be favourably influenced.The significant lipid element contributing of plaque formation appears to be low density lipoprotein cholesterol, but its derivation in plaques in quite complicated. Low density lipoprotein and possibly intermediate density lipoprotein, with a somewhat lower cholesterol content, are known to enter sub-in finial spaces directly and they may do so in association whit cellular migration. Locally produced endothelial-derived relaxing factor.Despite the massive study on the subject of lipids, atherogenesis and its complications, much of our therapeutic endeavour still relates to hypothesis rather than established facts based on observations in humans. Key Words: hyperlipidemia - lipoproteins diet - physical exercise - antilipidemic drugs
Klinefelter syndrome Ibnu Pranoto, Ibnu Pranoto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 23, No 03 (1991)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

A 10-year old boy presented small testicles, a small penis, hypospadia, scanty hair growth, and long legs and arms indicating Klinefelter syndrome. Klinefelter syndrome is one of the abnormality of excessive number of sex chromosomes in which the male phenotype presents female characteristics such as breast development, scanty hair growth, long arms and legs, small testes and high pitch voice.The examination in the above case reveals two X-chromosomes and one Y-chrtimosome in the nuclei of cells as the result of fertilization from XX ovum and Y spermatozoa or from X ovum with XY spermatozoa!. Research studies showed there were 70% XXYmale cases in which their XX chromosomes came from the mother, whereas the other 30% cases their XYchromosomes came from the father. Other studies showed the poSsible relationship of Klinefelter syndrome with the incidence of leukemia.The result of chrothosomal analysysindicates that the abOve case was trUIYKlinefelter syndrome.Key Words: Klinefelter syndrome - genital abnormality - XY chromosomes - genetic mapping - clinical generics
The influence of conservative management of premature rupture of the membrane On infant Morbidity and mortality Risanto Siswosudarmo, Risanto Siswosudarmo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 23, No 03 (1991)
Publisher : Universitas Gadjah Mada

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Abstract

Premature rupture of the membrane (PROM) still gives a great problem in obstetrics because of its high perinatal morbidity and mortality, and whether conservative or active management should be taken is still debatable. The aim of the present study is to evaluate a conservative management of PROM especially on infant morbidity and mortality. A total of 130 PROM cases with gestational age of 28 weeks or more and birth weight of 1000 grams or more were included into the study. Twin and major congenital anomalies were excluded. A total of 129 non-PROM cases during the same period were selected randomly serving as control. Data were processed with IBM compatible personal computer using version 2.0 SPSS program: t-test, chi-square test and relative risk (RR) were statistical analysis used in this study.Both groups were comparable, in terms of gestational age, birth weight, type of presentation, but not in parity. Results showed that the risk of getting neonatal infection was 1.82 (0.95-3.46). Although it was not statistically different, but i t was clinically important. Rupture of membrane more than 48 hours gave the highest risk of neonatal infection (RR 2.77; 95% CL 0.95-8.05). Neonatal asphyxia was more common in the PROM group compared to the non-PROM. One minute Apgar score indicated that the risk of severe asphyxia was 2.19 (L44-3.33) and the risk ofmoderate asphyxia was 1.84 (1.19-2.87). Evaluation after five minutes showed that such risk became 1.56 (0.12-19.19) and 3.13 (1.65-5.93) respectively. Perinatal death in both groups did not show significant difference, but neonatal death due to sepsis in the PROM group was about four-folds compared to the non-PROM. Death atrributed to respiratory distress syndrome did not show significant difference.The study concluded that conservative management resulted in a high infant morbidity, although the infant mortality was relatively the same. As neonatal asphyxia was more common in the PROM group, then adequate resuscitation should be prepared. Although prophylactic antibiotics had been given, neonatal death due to infection was still high.Key Words: PROM - neonatal infection - asphyxia - obstetrics - infant mortality
The Impact of Brain Technology on Mankind Soedjono Aswin, Soedjono Aswin
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 23, No 03 (1991)
Publisher : Universitas Gadjah Mada

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Abstract

Pemahaman dan penguasaan manusia atas proses-proses dan hukum-hukum lisis dan kimiawi, serta dasar-dasar biokimiawi dan biolisis proses-proses kehidupan, memberinya kemampuan yang seolah-olah tidak terbatas untuk memodifikasi gena, pikiran, emosi dan perilaku manusia. Perkembangan dan kecenderungan teknologi otak pada saat ini telah membangkitkan perhatian dan sekaligus kecemasan. Kemungkinan penerapan praktis teknologi otak dalam menanggulangi berbagai masalah klinis dan sosial senautiasa dilekati oleh dampak medic, hukum, etis dan sosial, baik positif maupun negatif.Teknologi otak memberi manusia kemampuan dan potensi untuk mengubah perilaku manusia dan keberadaannya di muka bumi ini, potensi merekayasa speciesnya sendiri, karena teknologi otak dapat dirancang untuk memodifikasi sifat-sifat dasar manusia. Dengan teknologi otak ini, di tangan manusia terletak kemampuan menembus, menyelidiki dan bahkan mengendalikan berbagai mekanisme pengendalian yang terdapat di dalam otaknya sendiri. Walaupun demikian, apa yang dapat dilakukan manusia tidak berarti boleh dilakukan. Masih banyak aspek kehidupan lain yang harus dijunjung tinggi dan dipertimbangkan sebelum melangkah,yaitu aspek-aspek moralitas, etis. dan religius, jika integritas manusia dan keberadaan speciesnya di planet bumi ini ingin dipertahankan.Key Words: brain technology - behavior - genetic engineering - psychotechnoiogy - morality

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