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Articles 6 Documents
Search results for , issue " Vol 25, No 04 (1993)" : 6 Documents clear
The Subfornical organ and limbic system of albino rats Daryanto, Daryanto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 25, No 04 (1993)
Publisher : Universitas Gadjah Mada

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Abstract

The objective of this study is to provide an account of anatomically connections between the subfomical organ and limbic system, using an immunofluorescent study with single fluorescent labeling tracer DAPI (4-6-diamidino-2-phenylindol dihydrochloride), on seven adult albino rats of Wistar strain weighing between 250 - 350 g.The result of this study revealed that the subfomical organ, anatomically connected to the limbic system.Key Words: subfomical organ - limbic system - DAPI - albino rat - inunUnofluorescent
Mucosal Immunity: Role of Gut-Associated Lymphoid Tissue (GALT) in IgA Response Marsetyawan HNE Soesatyo, Marsetyawan HNE Soesatyo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 25, No 04 (1993)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Imunitas mukosal ditandai dengan adanya sekresi imunoglobulin (Ig)A pada perrnukaan mukosa dan kelenjar sekretorik, dikenal sebagai secretory (s) IgA. Sistem imun mukosal berbeda dengan dan tidak tergantung pada sistem imun sistemik sebab IgA diproduksi oleh sel plasma lokal, berbentuk polimerik, dan kadar sIgA tidak berkaitan dengan kadar lgA monomerik di dalam sirkulasi darah. Secretory (s)IgA berperan melindungi mukosa tubuh terhadap kuman patogen, toksin bakterial, enzim-enzim, dan sejumlah besar antigen asing termasuk antigen protein dari makanan. Selain menggumpalkan bakteri, menetralisasi virus dan toksin, sIgA mampu menghalangi perlekatan mikroorganisme pada pemukaan sel epitel usus, sehingga invasi kuman ke dalam jaringan bisa dicegah. Proses ini dikenal sebagai immune exclusion. Selain itu sIgA tahan terhadap enzim proteolitik yang dihasilkan bakteri Gram (-).Saluran pencemaan sepanjang usus halus dan usus besar mengandung jaringan limfoid yang tersebar di dalam epitel, lamina propria, atau tersusun sebagai agregat seperti lempeng Peyer (Peyers patch. PP). Jaringan limfoid ini dikenal sebagai gut-associated lymphoid tissue (GALT). GALT, khususnya PP berfungsi sebagai tempat induksi respon IgA, sedangkan lamina propria sebagai tempat efektor respon imun mukosal. Induksi antigen pada PP akan mengaktifkan sel B yang diprogram untuk menghasilkan IgA atas bantuan T helper (TH), interleukin (IL-4, IL-5 dan IL-6) dan follicular dendrilic cells (FDC). Selanjutnya sel B spesifik bersama TH akan berrnigrasi ke limfonodi mesenterial, ductus thoracicus, sirkulasi darah dan beredar ke selumh tubuh. Akhimya sel B mengalami pemasakan menjadi sel plasma IgA yang slap mensekresi IgA ke perrnukaan mukosa, seperti saluran pemafasan bagian atas, saluran genital, dan saluran pencemaan. IgA juga dicurahkan ke dalam kelenjar-kelenjar sekretorik, seperti lalcrimal, ludah dan kelenjar susu. Peristiwa migrasi sel B dan sel T dari GALT dan kembali (homing) ke jaringan mukosa, balk yang letaknya dekat maupun jauh dari tempat induksi, merupakan dasar dari imunitas mukosal. Konsep ini dikenal sebagai sistem imun mukosal umum.Key Words: mucosal immune system - sIgA - Peyers patch - M cells - oral immunization:
The state of body iron in women anemic patients at Dr. Sardjito General Hospital Setyawati, Setyawati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 25, No 04 (1993)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Disorders resulting from body iron overload (hemosiderosis in reticgoendothelial cells or accumulation within parenchymal cells of the liver, heart and other organs) may octal- in patients who have undergone frequent blood transfusions or under other excessive iron therapy to treat the anemia. Therefore, every iron preparation especially by repeated parenteral route or blood transfusions must be accompanied by monitoring of body iron status.In the present study the most useful indirect measurement of ,body iron status, included serum ferritin (SF), serum iron (SI), total iron binding capacity (TIBC), transferin saturation (TS) and the erythrocyte, were studied in 34 women anemic patients at the Dr. Sardjito General Hospital.The results of the study are as follows: among 30 subjects with anemia caused by other than iron deficiency, included chronic renal diseases, inflammation or infection, hematologic and other organ malignancy, idiopathic thrombocytopenic purpura, the mean of SF level increased to 210,85ng/ml; but SI level (66,941g/d1) and TIBC (271, 07/µg/dl) showed no useful information about the state of iron stores, because its large biologic and analytic variability.In overall there was normal percentage of TS (25,58%), but among them 7 cases showed evidence of blood loss with TS less than normal, and erythrocyte indices within normal range.In 4 patients with uncomplicated iron deficiency anemia the mean of SF and 1S were low (4,62ng/ml and 11,85% respectively), although SI only slightly decreased (38,7/tig/d1), and the TIBC was normal (340,3ffig/d1). The blood smears showed variation of size in the erythrocyte, with many smaller than normal and pale RBCs.It is concluded that ferritin serum measurement was the most sensitive and non invasive indicator for early stage of iron deficiency assessment. However, in fact no single indicator or, combination of indicators is ideal for the evaluation of body iron status in all clinical circumstances, because each indicator may be by other conditions such as infections, inflammations, liver, chronic, renal disease and malignancy.Key Words: anemia - serum ferritin - serum iron - total iron binding capacity - transferin saturation
Dyslipidemia in type II diabetes mellitus: Pathophysiology and therapeutic approach Adiwijono, Adiwijono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 25, No 04 (1993)
Publisher : Universitas Gadjah Mada

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Abstract

Dyslipidemia occurs commonly in type II diabetes mellitus. Although all classes of lipoprotein may be involved, the most common lipid abnormality is increased triglycerides levels. The metabolic abnormalities associated with diabetes per se can have marked effects on serum lipids. In liver and adipose tissue, insulin has a key regulatory role of both lipid and carbohydrate metabolism pathways. If insulin secretion or action is abnormal, changes in fat and glucose metabolism will result. However, which changes will occur, is largely determined by the type of diabetes, the degree of insulin deficiency and the relative glycamic control. In many type II diabetes mellitus, it is likely that the etiology of dyslipidemia are multifactorial.There are three possible mechanisms that cause dyslipidemia in diabetes mellitus more atherogenic, i.e. glycosylation, oxidation and carbamylation processes. Since dyslipidemia and other risk factors for vascular diseases (obesity, hypertension, smoking) are frequently present, the approach to management must be broadly based.Association between diabetes mellitus and triglycerides, including relationship between disturbances of carbohydrate and lipid metabolism, provide the rational use of the antilipidemic agents, diet and sport.Key Words: diabetes mellitus - dyslipidemia - insulin - atherosclerosis - hypolipidemic agents
A comparative study of Cycloprovera and Depoprovera contraceptive methods. The menstrual patterns and continuation rates Soetrisno, Soetrisno
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 25, No 04 (1993)
Publisher : Universitas Gadjah Mada

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Abstract

The change of menstrual patterns caused by progestogen only contraception may influence the womens psychologic condition and sometimes requires discontinuation of its usage. Cycloprovera, a monthly injectable contraceptive method, containing progestogen + estradiol cypionate is considered to overcome the problems. The study was aimed at comparing the menstrual pattern changes and continuation rates between Cycloprovera and Depoprovera acceptors.The study is a part of a multicentered study comparing menstrual pattern changes between Cycloprovera and HRP 102 acceptors conducted in 5 countries including 7 research centers in Indonesia. For each Cycloprovera acceptors recruited in Yogyakarta, one Depoprovera acceptor was selected as control. Menstrual patterns and continuation rates of both groups were followed up in 3, 6. 9 and 12 months after having first injection. From July 1, to December 31, 1990. 31 acceptor for each group were recruited from several family planning clinics in Yogyakarta. The comparability of the two groups was not statistically significant except for blood pressure level. However, it was not clinically significant. The normal menstrual patterns was significantly higher in Cycloprovera group compared to Depoprovera group (p<0.05). No amenorrhoea and drop-out among Cycloprovera acceptors, while among Depoprovera group were 19.4%, 35.5%, 38.7% and 9.7%, 19.3%, 29.0% after 3, 6 and 9 to 12 months respectively. The changes of menstrual patterns after 3 and 6 months were significantly higher among Depoprovera groups compared to Cycloprovera (p<0.05), however, after 9 to 12 months were not statistically different (p<0.05).It is concluded that the menstrual patterns and continuation rates of Cycloprovera acceptors are better compared to Depoprovera acceptors, and no drop-out among Cycloprovera acceptors.Key Words: Cycloprovera - Depoprovera - menstrual patterns - user continuation rate - family planning clinic
Imunologi Masa Kini Anonim, Anonim
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 25, No 04 (1993)
Publisher : Universitas Gadjah Mada

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Abstract

Kata Kunci: Imunologi

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