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Articles 6 Documents
Search results for , issue " Vol 26, No 03 (1994)" : 6 Documents clear
Bahasa Indonesia Kedokteran Anonim, Anonim
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 26, No 03 (1994)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Kata Kunci: Bahasa Indonesia - Kedokteran
Molekul Major Histocompatibility Complex (MHC) Klas II pada Epitel Usus: Presentasi Antigen Luminal? Y. Andwi Ari S, Y. Andwi Ari S
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 26, No 03 (1994)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

The major histocompatibility complex (MHC) class II antigens were originally described to be expressed on the surface of B lymphocytes, macrophages, skin Langerhans cells (LC) and dendritic cells (DC). Surprisingly, the class Il molecules of MHC are also found in the intestinal epithelium.The distribution and expression of la molecules on intestinal epithelial cells depend on the continuous exposure of antigen and the presence of certain stimuli, like interferon-gamma, inflammation process in the gut and graft-versus-host disease. The function of class II molecules on intestinal epitheliurn may be different from those molecules on professional antigen presenting cells. Luminal antigens which are processed by enterocytes will be delivered to CD8 cells in the vinous epithelium and led to immunosuppression, whereas antigen uptake by M cells in the Peyers patches will be presented to CD4 cell populations, and initiate the immune response.Key Words : antigen processing-MHC molecule-enterocytes-Peyers patches-mucosal immunity
Secretion of a Novel Gene Product through Micro-encapsulated Recombinant Cells a Preliminary Report M. Mansyur Romi, M. Mansyur Romi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 26, No 03 (1994)
Publisher : Universitas Gadjah Mada

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Abstract

Galur sel hasil rekayasa genetik yang berada dalam kondisi terisolasi secara imunologis diharapkan dapat diimplantasikan kepada beragam penerima. Dengan demikian tersedia strategi altematif bagi terapi gena, yang umumnya bergantung kepada modifikasi genetik terhadap sel dari penderita sendiri. Penelitian ini mengamati ekspresi hormon pertumbuhan manusia (HPM) dari hasil rekayasa genetik sel mencit yang ditempatkan di dalam membran imunoprotektif secara in vitro.Sel mencit Ltk" ditransfeksi dengan plasmid pNMG yang mengicode gena HPM dan gena resistensi terhadap G418. Sel-sel yang mensekresi HPM dalam jumlah banyak dipilih untuk dibungkus dengan mikrokapsul berdiameter 300nm yang terbuat dari bahan alginate — polylysine — alginate. Prosedur pengkapsulan tidak mengganggu kelangsungan hidup sel, terbuicti bahwa lebih dari 95% sel masih tetap hidup seusai pengkapsulan. Sepanjang percobaan selama 3 minggu angka sel yang hidup dapat dipertahankan sekitar 90%, jumlah sel di dalam mikrokapsul meningkat lebih dari sepuluh kali lipat, dan HPM di dalam media juga meningkat konsentrasinya. Membran mikrokapsul cukup permeabel, dari perhitungan pada awal percobaan lebih dari 80% HPM yang disekresi dapat berdifusi ke dalam media. Dapat disampaikan bahwa produk gena baru dari galur sel baku hasil rekayasa genetik dapat dihantarkan melewati mikrokapsul dari bahan alginate-polysine-alginate secara in vitro paling tidak selama tiga minggu. Selain itu, prosedur yang dikerjakan cukup memadai bagi kelangsungan hidup sel, lingkungan dalam mikrokapsul dapat mendukung pertumbuhan sel, dan membran kapsul bersifat permeabel bagi produk gena baru.Key words: genetically modified cells-plasmid pNMG-human growth hormone-immuno protection-microcapsule
Olfactory threshold values of C4VOE as test agents for measuring the olfactory capability Sukardjo, Sukardjo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 26, No 03 (1994)
Publisher : Universitas Gadjah Mada

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Abstract

The preliminary clinical study on seven volatile agents and their olfactory threshold values of cadinum, camphora, capsaicin, carbon disulphide, vanilla, oleum menthae piperitae and ether has been performed. Their concentrations in solution and as a vapour could be measured by regression calculation. The olfactory detection threshold of these evaporated agents constituted the following concentrations: cadinum 0.12325/0.007968, camphora 0.01993/0.0045364, capsaicin 0.0118/0.0007573, carbon disulphide 0.02703/0.0066363, vanilla 0.01884/0.004255, oleum menthae piperitae 0.01228/0.002064, and ether 0.014801/0.0003613. These agents could be normally recognized by healthy volunteers.The concentration of the agents can be drawn and displayed in linear graphic by arithmetic logarithm with 30% different vapour concentration for each agent. These volatile agents as test materials, based on these findings were called "C4VOE-GAMA Olfactometer". A clinical study to fmd out the normal standards of the olfactory threshold and the use of this test material in measuring the olfactory capability in cases of nasal pathology is suggested.Key words : C4VOE-LAMA olfactometer-volatile agent-olfactory threshold value-gas chromatograph
Talasemia di Rumah Sakit Umum Pusat Dr. Sardjito Tahun 1986 - 1992 Sunarto, Sunarto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 26, No 03 (1994)
Publisher : Universitas Gadjah Mada

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Abstract

Thalassemia is a great health problem in the affected countries, especially in the developing countries including Indonesia. There is no curative therapy up to now, while the supportive therapy should be done life4ong and such therapy brings many problems to the patients and an enormous burden to the community who should afford the health services.Ninety thalassemia syndrome, at Dr. Sardjito General Hospital during the period of 1986-1992 were retrospectively studied. The diagnosis was based on clinical manifestations, routine blood examination, HbF investigation either with alkali denaturation test or electrophoresis and on the evidence of trait in the parents. Thirty six patients had undergone molecular studies. Aspects of therapy were also studied.The study found that 57 and 33 patients were major thalassemia and thalassemia-hemoglobin E disease, respectively. There was no difference between major thalassemia and thalassemia-hemogolobin E disease in term of male and female proportion (p > .05), and on the level (p > .05). Foutty eight patients came from Yogyakarta Province, the rest came from various parts of Java, especially nearby Yogyakarta Province. Compared with the estimation, we conclude that many thalassemic patients had not yet been covered. The expenses for supportive therapy were so great, while most of the patients belonged to the middle to low sosioeconomic level, so that only 30-40% had come regularly for routine transfusion. Among the 36 patients who underwent molecular studies, 31 have been genotypically identified. Molecular diagnostic was aimed at the first step of prenatal diagnosis.Key words: thalassemia syndrome-thalassemia trait-blood transfusion-molecular study-prenatal diagnosis
Protective immure responses against fatal malarial infection in mice with blood stage malaria vaccin. Supargiyono, Supargiyono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 26, No 03 (1994)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Studies were carried out to establish suitable infection and immunization method to facilitate investigation on the protective host immune responses against acute malarial infection. Combinations of experimental model using two species of rodent malaria parasites Plasmodium vinckei vinckei and Plasmodium vinckei petteri, two immunization methods were tested, to determine which model are suitable for studying any aspect of host immune responses during protective malarial immunization.The results indicated that the infection of P. v. vinckei and P. v. petteri in LACA or in BALB/c mice generally produce acute and lethal infections. Infection of P.v.vinckei in these experimental models seems more severe than P. v. petteri, and neither intravenous nor intraperitoneal immunization gave significant protection against homologous infection. However, immunization using 108 blood stage parasite P. v. petteri could protect LACA mice from the lethality of homologous challenge, and it seems that cell mediated mechanisms play an important role in host responses against infection. Therefore, P. v. petteri infection in LACA mice and immunization using 10 blood stage parasites given intravenously or intraperitoneally represent a suitable model to study some aspects of host immune response mechanism during malarial immunization.Key Words : Plasmodium vinckei vinckei - Plasmodium vinckei petteri - immune response - cellular immunity - homologous parasites

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