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Articles 7 Documents
Search results for , issue " Vol 36, No 1 (2004)" : 7 Documents clear
Risk predictor for ma/aria in pregnancy and the role of chloroquine in /ow endemic area Iwan Dwiprahasto, Iwan Dwiprahasto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 36, No 1 (2004)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Pregnant women in malaria-endemic areas are uniquely susceptible to infection with Plasmodium falciparum and this susceptibility is greatest during first pregnancies. Malaria causes serious complications in pregnant women, especially in those who have a low level of acquired immunity before pregnancy.Objective: to assess the risk predictors for malaria during pregnancy and the role of chloroquine in low endemic area of malaria in Jepara districtDesign: A longitudinal study of all pregnant mother was carried out in Batealit and Mayong I subdistricts of Jepara district between June 1997-August 1999. All pregnant women were screened for peripheral parasitaemia through active surveillance. Women who had parasitaemia were treated with chloroquine for 3 days. Blood smears were then examined on days 4, 7, 14 and 21 after completion of the chloroquine course. All women irrespective of the blood smear results at enrolment were followed up once every two weeks until delivery.Results: Among 3099 pregnant women enrolled in the study, only 58 women had malaria infection, giving an incidence rate of 1.9/100 pregnant women. In this study low income is a significant risk predictor for malaria (OR= 11.03; 95%Cl: 3.91-31.08). Women who had reported a history of malaria or history of taking antimalarial drugs 6 months before their last menstrual period (LMP) showed an increased risk of developing malaria during pregnancy (OR= 10.56; 95%Cl: 4.57-23.72 and OR = 10.90; 95%Cl: 4.4825.61) respectively. Among those infected by P.falciparum and P. vivax and treated with chloroquine, complete parasite clearance was found in day 7.Conclusions: This study shows that low income, history of malaria within 6 months before LMP and history of taking antimalarial drugs within 6 months before LMP are best predictor for malaria in pregnancy in low endemic area. This study also shows that chloroquine is still effective for treating malaria falciparum in pregnancy in Batealit and Mayong I subdistricts, JeparaKeyword: malaria - pregnancy - low endemic area - risk-predictor - chloroquine
Allometrical correlation of biacromial and bicristal breadth to height growth in 7-15 years old children in Bantul Regency Yogyakarta Province Janatin Hastuti, Janatin Hastuti
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 36, No 1 (2004)
Publisher : Universitas Gadjah Mada

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Background: Changes in body measurements during growth period cause change in their proportion, and this relationship can be measured using allometrical method. Growth of biacromial and bicristal in children are specific, because they can indicate the sexual dimorfism between boys and girls. Objective: The aims of this studi are to know the relationship between growth of biacromial and bicristal breadth to growth of height in 7-15 years old boys and girls in Bantul Regency, Yogyakarta Province. Methods: Investigation was conducted in 284 children of 7 up to 15 years old which consist of 136 boys and 148 girls. The samples were divided into 9 groups and were measured on height, biacromial and bicristal breadth. The datas were analysed using allometrical method expressed by an exponential regression equation. Student-t analysis was use to determine the difference of each measurement between boys and girls at the same age.Result: The result showed that biacromial breadth grew faster proportionally to height in 7 up to 11 and 13 up to 15 year old boys, and on the 7, 8, and 10 up to 15 years old girls. Bicristal breadth grew faster proportionally to height for all groups of age. Biacromial breadth grew faster proportionally to bicristal breadth th 8 up to 9 and 13 up to 15 year old boys and 7 year old girls. Girls of 8 up to 15 years old grew slower on biacromial breadth compared to bicristal growth.Conclusions: The conclusion was biacromial and bicristal breadth grew faster proportionally to height of boys and girls for almost all of age. Biacromial breadh of boys grew faster than bicristal breadth. In contrast, biacromial breadth of girls in the same age grew slower than bicristal breadth.Key words: growth-stature-biacromial breadth-bicristal breadth-allometrical method
Effect of autovaccine on bacterial infection in mice Ning Rintiswati, Ning Rintiswati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 36, No 1 (2004)
Publisher : Universitas Gadjah Mada

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Background: In the present time therapy with antibiotics does not always solve the problem of infectious disease. Many factors influence infectious disease including immun mechanism, disease, resistant strain of microorganism, etc. Immunotherapy using autovaccine could be an alternative therapy, especially on chronic ulcer.Objective:The study observed the effect of autovaccine on ulcer of mice infected by various single bacteria and mix of bacteria.Methods :One hundred and eighty female mice were divided into 3 groups, group 1 was infected by Stapylococcus aureus, group 2 by E.coli, group 3 by mix bacteria (P. aeruginosa, Stapylococcus aureus, E. cob), and ten mice served as control. Half of each group of infected mice then was given autovaccine subcutaneously once a day for seven days. Development of skin lession was observed daily until recovery occured. Titer antibody against bacterial was evaluated using agglutination test.Results: Autovaccine group recovered faster than untreatment group. Number of death in infected group was higher than control group. Autovaccine increase antibody titer in mix bacterial infected group, and group infected by S.aureus, but had no effect on antibody production on group infected by E.coli. Conclusion: Autovaccine has no effect on recovery of skin lession of single infected mice, but effective to heal in mix infected mice.Key words: autovaccine - immunostimulator - bacterial infection - antibody - ulcer healing
The effect of the administration of vitamin K2 to the pregnant women on the activities of prothrombin group in cord blood. Rahajuningsih D. Setiabudy, Rahajuningsih D. Setiabudy
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 36, No 1 (2004)
Publisher : Universitas Gadjah Mada

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Background: Hemorrhagic disease of the newborn (HDN) is a hemorrhage at the neonatal period. The most dangerous form of HDN is intracranial bleeding which may be fatal. The most frequent cause of HDN is deficiency of vitamin K dependent factors or prothrombin group.Objective: The aim of the study is to know the effect of the administration of vitamin K2 to the pregnant women on the activities of prothrombin gourp in cord blood.Methods: This was experimental design. Forty pregnant women were enrolled in this study. Vitamin K2 was given orally at the dosage of 10 mg twice daily. At delivery the cord blood was collected for the measurement of prothrombin group activities.Results: In the treatment group the median activities of prothrombin were 37.3%, F VII were 62.4%, F IX were 29.5%, and F X were 34.9%, while in the control group the median activities of prothrombin were 33.5%, F VII were 47.3%, F IX were 23.7%, and F X were 29.0%. The difference of the activities of vitamin K dependent factors between treatment group and control group was statistically significant. Conclusion: The administration of vitamin K2 to the pregnant women increases the activities of vitamin K dependent factors in the cord blood.Key words: hemorrhagic disease of the newborn - oral vitamin K2 - cord blood - vitamin K dependent factor activity
Differentiation and identification of Aedes albopictus Skuse from several population in Indonesia based on genetic polymorphisms Budi Mulyaningsih, Budi Mulyaningsih
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 36, No 1 (2004)
Publisher : Universitas Gadjah Mada

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Background: Aedes albopictus play important role in the spread dengue virus, it is spread widely in Indonesia. Geographical condition of Indonesia which shows varying climatology, biogeography and environmental factors seem to be very possible to cause the difference in the genetic structure of Ae. albopictus.Objective: The aim of this study is to determine the genetic polymorphism of each Ae. albopictus population.Methods: Genomic DNA was extracted from individual mosquitoes from 4 geographic populations of Ae, albopictus and amplified in PCR reactions using single primers of arbitrary nucleotide sequence.Result: The DNA polymorphism level of Ae. albopictus population originated from Yogyakarta is 80.77%, followed by population originated from Padang is 57.14%, Banjar is 40.74% and Timika is 37.50%. Conclusion: The genetic structure of the Ae. albopictus populations shows obvious differences, and they shows that they are from different group and separated with the various difference percentage.Key words: genetic polymorphism - population - Ae. albopictus - dengue virus - RAPD-PCR.
Glycosilation reaction models and the role of Madagascar periwinkle (Catharanthus roseus CU G. Don) S leaves infusion as protein damage inhibitor Rizky Taufan Firdaus, Rizky Taufan Firdaus
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 36, No 1 (2004)
Publisher : Universitas Gadjah Mada

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Background : Glycosilation is a reaction between protein and glucose in high concentration. The basic of this reaction is the continuous increase of glucose concentration, followed by a hooking between glucose with the amin primary structure of the protein. Beside form the AGEs, glycosilation reaction forms free radicals as the side product. The free radical reaction with the protein forms a crosslinking of the protein and then change the structure of the protein.Objectives : This research was carried out to know glycosilation reaction model and the role of madagascar periwinkle ICatharanthus roseus ELI G. Don) s leaves infusion as protein damage inhibitor. Method : This research is an experimental and explorative research. This research was carried out in two steps, the making of infusion and the test for protein damage inhibition by using the infusion of madagascar periwinkle s leaves and glyclazide.Result : The activity of madagascar periwinkles leaves infusion to inhibit the protein damage is 21,29% while the activity of glyclazide is 96,77%.Conclusion : The infusion of madagascar periwinkle (Caiharanihus roseus EL.] G. Don)s leaves can inhibit the protein damage because of the glycosilation reaction but lower than the glyclazides.Key words : Madagascar periwinkle - glycosilation - free radical - protein damage
Epidemiology of cervical-root caries on teeth: High prevalence in the coca leaf chewing in the Andean people. Etty Indriati, Etty Indriati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 36, No 1 (2004)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Cervical-root caries on teeth often called rampant caries or circular caries often suffered by children who consumed bottled sweet milk. In adult, cervical-root caries occurs in unique cases such as cancer patients who undertake chemotherapy, and narcotic addicts.Objective: The research was aimed to study the dental and oral health of Andean people who have traditionally been chewing coca-leaves as a part of their cultural and integral lives.Materials and Method: The subject of study was 210 Aymara people from highland Chile and Bolivia, Andes. They were given questionnaire whether they chew coca leaves or not. Without knowing whether one chewed coca leaves or not, each individual was examined for: the carious teeth, the caries location, the periodontal stage, the oral pH, the molar radices, the molar loss, and the total number of teeth preserved.Result: The result showed that people who chewed coca-leaves every day suffered cervical-root caries on their molar teeth, only radices of molars preserved, or even lost their molar teeth. They also suffered tongue desquamation and periodontal damage at the buccal area of molar teeth. In contrast, those who did not chew coca-leaves were relatively free from these dental disadvantages. Statistical analysis showed significantly high correlation between duration and intensity of chewing coca leaves with dental disadvantages (R=0,62 for molar loss; R=0,63 for bad periodontal status; and R =0,54 for cervical-root caries).Conclusion: It is concluded that habitual chewing of coca leaves damaged the periodontal region of the molar area, caused the root of the molar teeth to expose and led to cervical-root caries, then, only roots of molar preserved, and last, the lost of molar teeth. The high prevalence of cervical-root caries in coca-leaves chewers is in accord with other conditions such as cancer patients who undertake chemotherapy, and narcotic addicts. The alkaloid in the coca leaves are associated with the drying out the mouth leading to less self-cleansing and damaging the cervical-root area. Understanding the cultural tradition in a society is important if we were to understand the disease processes.Key words: coca leaves - Andes - epidemiology - cervical-root caries - molar

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