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Articles 8 Documents
Search results for , issue "Vol 21, No 04 (1989)" : 8 Documents clear
Thermobiology and Clinical Application of Interstitial and Superficial Hyperthermia in Two Groups of Patients: a New Approach for Treating Malignant Tumors Maesadjie Tjokronagoro, Maesadjie Tjokronagoro
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 21, No 04 (1989)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (353.894 KB)

Abstract

Two groups of patients were treated with combined modality radiation and hyperthermia at the Strahlentherapeutische Klinik, Universitit Erlangen-Nurnberg, Federal Republic of Germany, from October 1987 to July 1988. The first group of 8 patients (4 cases of carcinoma of-the floor of the mouth, 3 cases of tongue carcinoma, 1 case of Ewing sarcoma) was treated with combination radiation and interstitial hyperthermia. 7 cases have complete remission (87.5%), whereas 1 case has partial remission (12.5%). The second group of 6 patients (5 breast cancer recurrences in the chest wall and supraclavicular region, 1 case with cancer of the parotid gland) were treated with combined radiation of electron beam 12 Mev by Siemens Mevatron 20 and superficial hyperthermia using Lund Buehler hyperthermia system 4010, 915 MHZ/20 W, once a week. 4 cases have complete remission (66.6%) and two cases have partial remission (33.3%). As a background of hyperthermia we also describe the principles of thermobiology, heat interaction with irradiation, physiologic mechanisms, and effects of hypertherrnia on microvasculature of tumors as well, as basic principles of physics and instrumentation of hyperthermia.key words: cancer-hyperthermia-radiation therapy-thermobiology-thermometry
Tegralogy of Fallot: Pro-and post-surgical case study A. Samik Wahab, A. Samik Wahab
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 21, No 04 (1989)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (306.351 KB)

Abstract

Defects in the ventricular septum with obstruction to right ventricular outflow encompass a wide anatomic, physiologic and clinical spectrum. Large ventricular septal defects occur with pulmonic stenosis that varies from mild to severe to complete (pulmonary atresia). Small ventricular septal defects occur with mild to severe pulmonic stenosis. The most familiar and prevalent combination is tetralogy of Fallot with the incidence of approximately 0.4 to 0.6 per 1000 live births.The following illustrates four cases of Fallots tetralogy with a wide anatomic, physiologic and clinical variations. The first case is a small ventricular septa defect along with severe pulmonic stenosis, the fourth case, however, comprises a large VSD and pulmonary atresia, while in the others the anatomic variations are in between.Hypoxic spells are important aspects of the history in Fallots tetralogy. Spells are an alarming episode that should be treated as an emergency. Knee-chest position, squatting or sitting with legs drawn underneath can afford to relief dyspnea.The best treatment, however, is surgical treatment, indicated in all patients with Fallots tetralogy. The result of this surgical treatment up to now is very satisfactory.Key Wards: tetralogy of Fallot - pulmonic stenosis - ventricular septal defect - pulmonary atresia - bicuspid a pulmonalis
Prealbumin level at biochemical marker of nutritional assessment in premature infants Achmad Surjono, Achmad Surjono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 21, No 04 (1989)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (230.568 KB)

Abstract

Controversies in adequate nutrition for premature infants still exist. No single anthropometric or biochemical measures currently available are reliable for premature nutritional assessment.The aim of this study is to determine the usefulness of serial prealbumin serum levels in identifying adequacy of nutritional intake in premature infants during their neonatal period. A group of 18 infants ranging in birthweight between 1030-2050 g, nursed in the Dr. Sardjito Hospital until one month of age were included for study. Breast and formula milk were given in increasing amount and depending upon acceptance 120 Cal/kg of body weight/day should be achieved. Peripheral capillary blood samples were obtained for prealbumin examinations (by radial-immunodiffusion method) on the first day and at weekly interval afterwards. The infants were weighed daily and serum albumin was examined on 14 and 28 days of age.It turns out that the mean serum prealbumin in the first day of life was 7.9 ± L8 mg% and a significant increment levels on weekly measurements were obtained. It is shown that no correlation was found.between the prealbumin and albumin levels. Body weights correlated poorly with serial prealbumin values.It seems that prealbumin, with a short half-life of 1.9 days can be used as a sensitive nutritional assessment in premature infants. Modifying of adequate protein and caloric provision could be applied early to prevent malnutrition in the neonatal period of premature infants.Key Words: prealbumin - serum albumin - premature infants - nutritional assessment - caloric requirement
Genetic heterogeneity of retinitis pigmentosa Hartono, Hartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 21, No 04 (1989)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (315.037 KB)

Abstract

Genetic heterogeneity is a phenomenon in which a genetic disease can be transmitted by several modes of inheritance. The understanding of genetic heterogeneity is important in giving genetic counselling.The presence of genetic heterogeneity can be explained by the existence of:1.different mutant alleles at a single locus, and2.mutant alleles at different loci affecting the same enzyme or protein, or affecting different enzymes or proteins.To have an overall understanding of genetic heterogeneity, the heterogeneities of chronic hemolytic anemia caused by beta-globin abnormality, chronic hemolytic anemia due to thalassemias, and mucopolysaccharidoses have been chosen as examples.The article is focused on the genetic heterogeneity of retinitis pigmentosa, a kind of retinal hereditary disease. The genetic heterogeneity of retinitis pigmentosa can be known by the facts thata.Retinitis pigmentosa can be either an isolated disease or a part of a certain syndrome.b.Retinitis pigmentosa as isolated disease can be genetic or non-genetic in nature.c. Retinitis pigmentosa as a genetic disease can be transmitted either by autosomal dominant, autosomal recessive, or X-linked recessive genes.The frequency of isolated hereditary retinitis pigmentosa varies between 30% to 50%. Clinically the dominant form is milder than the recessive form. Certain syndromes associated with retinitis pigmentosa which need to be mentioned are Usher syndrome, Laurence-Moon-Bardet-Biedl syndrome, and Kearn-Sayre syndrome.Key Words: genetic heterogeneity - retinitis pigmentosa - genetic disease - hemolytic anemia - Usher syndrome
Genetic heterogeneity of retinitis pigmentosa Hartono, Hartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 21, No 04 (1989)
Publisher : Journal of the Medical Sciences (Berkala ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (315.037 KB)

Abstract

Genetic heterogeneity is a phenomenon in which a genetic disease can be transmitted by several modes of inheritance. The understanding of genetic heterogeneity is important in giving genetic counselling.The presence of genetic heterogeneity can be explained by the existence of:1.different mutant alleles at a single locus, and2.mutant alleles at different loci affecting the same enzyme or protein, or affecting different enzymes or proteins.To have an overall understanding of genetic heterogeneity, the heterogeneities of chronic hemolytic anemia caused by beta-globin abnormality, chronic hemolytic anemia due to thalassemias, and mucopolysaccharidoses have been chosen as examples.'The article is focused on the genetic heterogeneity of retinitis pigmentosa, a kind of retinal hereditary disease. The genetic heterogeneity of retinitis pigmentosa can be known by the facts thata.Retinitis pigmentosa can be either an isolated disease or a part of a certain syndrome.b.Retinitis pigmentosa as isolated disease can be genetic or non-genetic in nature.c. Retinitis pigmentosa as a genetic disease can be transmitted either by autosomal dominant, autosomal recessive, or X-linked recessive genes.The frequency of isolated hereditary retinitis pigmentosa varies between 30% to 50%. Clinically the dominant form is milder than the recessive form. Certain syndromes associated with retinitis pigmentosa which need to be mentioned are Usher syndrome, Laurence-Moon-Bardet-Biedl syndrome, and Kearn-Sayre syndrome.Key Words: genetic heterogeneity - retinitis pigmentosa - genetic disease - hemolytic anemia - Usher syndrome
Tegralogy of Fallot: Pro-and post-surgical case study A. Samik Wahab, A. Samik Wahab
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 21, No 04 (1989)
Publisher : Journal of the Medical Sciences (Berkala ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (306.351 KB)

Abstract

Defects in the ventricular septum with obstruction to right ventricular outflow encompass a wide anatomic, physiologic and clinical spectrum. Large ventricular septal defects occur with pulmonic stenosis that varies from mild to severe to complete (pulmonary atresia). Small ventricular septal defects occur with mild to severe pulmonic stenosis. The most familiar and prevalent combination is tetralogy of Fallot with the incidence of approximately 0.4 to 0.6 per 1000 live births.The following illustrates four cases of Fallot's tetralogy with a wide anatomic, physiologic and clinical variations. The first case is a small ventricular septa' defect along with severe pulmonic stenosis, the fourth case, however, comprises a large VSD and pulmonary atresia, while in the others the anatomic variations are in between.Hypoxic spells are important aspects of the history in Fallot's tetralogy. Spells are an alarming episode that should be treated as an emergency. Knee-chest position, squatting or sitting with legs drawn underneath can afford to relief dyspnea.The best treatment, however, is surgical treatment, indicated in all patients with Fallot's tetralogy. The result of this surgical treatment up to now is very satisfactory.Key Wards: tetralogy of Fallot - pulmonic stenosis - ventricular septal defect - pulmonary atresia - bicuspid a pulmonalis
Prealbumin level at biochemical marker of nutritional assessment in premature infants Achmad Surjono, Achmad Surjono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 21, No 04 (1989)
Publisher : Journal of the Medical Sciences (Berkala ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (230.568 KB)

Abstract

Controversies in adequate nutrition for premature infants still exist. No single anthropometric or biochemical measures currently available are reliable for premature nutritional assessment.The aim of this study is to determine the usefulness of serial prealbumin serum levels in identifying adequacy of nutritional intake in premature infants during their neonatal period. A group of 18 infants ranging in birthweight between 1030-2050 g, nursed in the Dr. Sardjito Hospital until one month of age were included for study. Breast and formula milk were given in increasing amount and depending upon acceptance 120 Cal/kg of body weight/day should be achieved. Peripheral capillary blood samples were obtained for prealbumin examinations (by radial-immunodiffusion method) on the first day and at weekly interval afterwards. The infants were weighed daily and serum albumin was examined on 14 and 28 days of age.It turns out that the mean serum prealbumin in the first day of life was 7.9 ± L8 mg% and a significant increment levels on weekly measurements were obtained. It is shown that no correlation was found.between the prealbumin and albumin levels. Body weights correlated poorly with serial prealbumin values.It seems that prealbumin, with a short half-life of 1.9 days can be used as a sensitive nutritional assessment in premature infants. Modifying of adequate protein and caloric provision could be applied early to prevent malnutrition in the neonatal period of premature infants.Key Words: prealbumin - serum albumin - premature infants - nutritional assessment - caloric requirement
Thermobiology and Clinical Application of Interstitial and Superficial Hyperthermia in Two Groups of Patients: a New Approach for Treating Malignant Tumors Maesadjie Tjokronagoro, Maesadjie Tjokronagoro
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 21, No 04 (1989)
Publisher : Journal of the Medical Sciences (Berkala ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (353.894 KB)

Abstract

Two groups of patients were treated with combined modality radiation and hyperthermia at the Strahlentherapeutische Klinik, Universitit Erlangen-Nurnberg, Federal Republic of Germany, from October 1987 to July 1988. The first group of 8 patients (4 cases of carcinoma of-the floor of the mouth, 3 cases of tongue carcinoma, 1 case of Ewing sarcoma) was treated with combination radiation and interstitial hyperthermia. 7 cases have complete remission (87.5%), whereas 1 case has partial remission (12.5%). The second group of 6 patients (5 breast cancer recurrences in the chest wall and supraclavicular region, 1 case with cancer of the parotid gland) were treated with combined radiation of electron beam 12 Mev by Siemens Mevatron 20 and superficial hyperthermia using Lund Buehler hyperthermia system 4010, 915 MHZ/20 W, once a week. 4 cases have complete remission (66.6%) and two cases have partial remission (33.3%). As a background of hyperthermia we also describe the principles of thermobiology, heat interaction with irradiation, physiologic mechanisms, and effects of hypertherrnia on microvasculature of tumors as well, as basic principles of physics and instrumentation of hyperthermia.key words: cancer-hyperthermia-radiation therapy-thermobiology-thermometry

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