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Articles 14 Documents
Search results for , issue "Vol 33, No 03 (2001)" : 14 Documents clear
Prognostic significance of argyrophilic nucleolar organizer region (AgNOR) counts and nutritional status in pediatric acute lymphoblastic leukemia (ALL). Wisman Herminto, Wisman Herminto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 03 (2001)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: The cell proliferation rate is a well-established prognostic factor in cancer, but it has not been considered as a prognostic factor used to stratify ALL patients into risk groups.Objective: The main goal of this study was to verify the relationship between AgNOR number and nutritional status, at the time of diagnosis, and remission induction response rate and survival in ALL patients. Methods: Smears of marrow aspirates from 35 newly diagnosed and previously untreated ALL patients were stained, at presentation, by silver method and evaluated by counting the mean AgNOR number of each case. Anthropometric nutritional status was obtained also for each patient.Results: The mean AgNOR number of the whole series was 3.54 ± 0.74. It was significantly higher in resistant patients than in patients who achieved complete remission (p = 0.01). It was found that the mean AgNOR number = 4 was related to the lower remission induction response than the mean AgNOR number < 4 (p = 0.02). Multivariate analysis by Cox regression model showed that the mean AgNOR number retained its prognostic significance as a predictor of survival (p = 0.04). Conversely, nutritional status was not correlated with remission induction response, and was not of prognostic significance, either.Conclusion: AgNOR number at diagnosis is a reliable prognostic parameter to predict remission induction response rate and survival in childhood ALL, and should be rountinely introduced in the group risk definition.Keywords: AgNOR - nutritional status - prognostic factor - pediatric ALL
The relationship between p53 expression, cell proliferation index and epidermal thickness in psoriasis Sekar Djatiningrum, Sekar Djatiningrum
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 03 (2001)
Publisher : Universitas Gadjah Mada

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Abstract

Background: The specific process among psoriatic lesions is keratinocyte hyperproliferation state, and one of the genes that controls cell cycle is wild type of p53 gene. The correlation between p53 overexpression and psoriatic keratinocytes hyperproliferation has not been established yet. Objective: To clarify the relationship between p53 overexpression and psoriatic keratinocyte proliferation index, as well as the epidermal thickness resulted from this proliferation.Methods: 50 paraffin-embedded tissue sections were chosen from block collection of Pathologic Anatomy Department. The p53 overexpression was measured by counting the number of positive cell among 500 cell stained by antibody anti p53. The cell proliferation index was measured by counting the number of black dot among 100 epidermal cells stained by silver nitrate. The epidermal thickness, represented by the thickness of epidermal rete ridges was measured by using calibrated micrometer in hematoxillin stained section.Results: p53 expression was significantly correlated in fairly degree with cell proliferation index (r, = + 0,47; P < 0,001) and significantly correlated in moderately degree with epidermal thickness (r, = + 0,57; P < 0,001). Cell proliferation index was significantly correlated in fairly degree with epidermal thickness (r1 = + 0,37; P < 0,004).Keywords: psoriasis - p53 - cell proliferation index - Ag NOR - epidermal thickness
Hypertension as one of the risk factors for age-related macular degeneration Soni Priartso, Soni Priartso
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 03 (2001)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Age-related macular degeneration (ARMD) is one of the causes of loss of central vision in older people. While age is the undisputed, the most important risk factors such as genetic, race, sex, sunlight exposure, diet, vitamin, smoking, cardiovascular disease, hypercholesterolemia, and hypertension have been incriminated to be associated with the development of ARMD. The study of ARMD is very rare in Indonesia.Objectives: To investigate the possible association of presumed hypertension, and other risk factors in patients with age-related macular degeneration.Methode: A case-control study of 120 subjects, 60 cases with ARMD and 60 cases of normal control in Dr. Sardjito General Hospital and Dr. YAP. Eye Hospital, Yogyakarta. ARMD and normal control were compared. Interview, eye examination, blood pressure, and blood sample were performed. Results: Hypertension was observed in 38 (76%) of 60 patients with age-related macular degeneration. Of 60 normal control patients, only 12 (24%) had hypertension. Statistical analysis result showed that hypertension was one of the risk factors for the development of age-related macular degeneration OR: 6,909 (3,037-15,720). But hypertension was not a predictor for the development of age-related macular degeneration (regression coefficient = 0,0000).Conclusion: Besides other risk factors, hypertension is one of the risk factors for the development of age-related macular degeneration.Keywords: age-related macular degeneration - central vision - older people - risk factors - hypertension
The correlation between the absolute eosinophil count and the degree of asthma attack in children Sumadiono, Sumadiono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 03 (2001)
Publisher : Universitas Gadjah Mada

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Abstract

Background: The presence of eosinophil in the blood count during an asthmatic attack has been the focus of study. More airway collapse occured in the eosinophil-positive patients, even the eosinophil-positive patients had a much higher incidence of respiratory failure and mechanical ventilation use than the eosinophil-negative group.Objectives: The purpose of this study was to know the correlation between the eosinophil count and the degree of the asthma attack in children.Methods: The subjects of the study were medical records of the asthmatic children who were hospitalized in Sardjito Hospital from 1995 to 2000. The asthma criteria was according to the international consensus. The asthma attack degree evaluation was according to GINA classification. Exclusion criterias: the patients with parasitic infection and no asthmatic respiratory disturbances patients.Results: There were 169 asthmatic patients hospitalized in Sardjito Hospital from 1995 to 2000. The incidence of the hospitalized asthmatic patients was tend to increase from year to year. The percentage of the asthmatic patients with mild and severe degree attack tend to increase. The mean of the absolute eosinophil count in some degree attack group were 143.4 in mild 221.9 and in severe degree attack group were 350.7.Conclusion: There was no significant difference of the absolute eosinophil count between some, mild and severe degree attack of the asthma patients.Keywords: asthma - children - eosinophil - degree of attack
The benefits of steroid as therapy for tuberculous effusion Barmawi Hisyam, Barmawi Hisyam
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 03 (2001)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Tuberculous effusion is a complication of pulmonary or extra pulmonary tuberculosis. The specific diagnosis is made by the finding of mycobacterium in the effusion and pleural tissue. Therapy of tuberculous effusion is mainly reducing symptoms, prevent progressivity and fibrothorax. Common complications of tuberculous effusion are pleural fibrosis, thickening and calcification of pleura. To prevent those, corticosteroid is often needed as additional therapy, besides anti tuberculous drugs. There has been controversy about the benefits of steroid as therapy for tuberculous effusion.Keywords : pulmonary tuberculosis, extrapulmonary tuberculosis, tuberculous effusion, corticosteroids, anti tuberculous drugs.,
Evaluation of prophylactic antibiotics to prevent early - onset clinical neonatal sepsis in newborn with potential infection. T. Darmawati, T. Darmawati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 03 (2001)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Over used prophylactic antibiotics on the potensially infected newborns to prevent early-onset sepsis causes greater risk for antibiotic resistance and changes of bacterial spectrum. Objectives: To know the efectiveness of prophylactic antibiotics to prevent early-onset clinical neonatal on the newborns with potential infection.Methods: Retrospective cohort study, neonates born in the Maternal Perinatal Installation of Dr. Sardjito General Hospital in Yogyakarta, from February 2000 to January 2001, were evaluated the risk factor of potential infection included premature rupture of the membranes, claudy or bad smell of amnion fluid, low birth weight, preterm, severe asphyxia with invasive procedure. Two groups in the study, were neonates with prophylactic antibiotics and neonates without prophylactic antibiotics. They were observed at least 7 days after delivery to find early-onset clinical neonatal sepsis.Results: There were 140 newborns studied, 50 newborns were given prophylactic antibiotics and 90 new borns without prophylactic antibiotics. Chi Square and t-test were applied for gestational age at delivery, peripartum 5 minutes. No significant difference between two groups (p>0.05) was found, early-onset neonatal sepsis in control group was 14/50 (28%) and in case group was 20/90 (22.2%)) = 0.445). Relative risk for sepsis was 0.79 (95% CI:0.303 - 0.078). Number needed to treat (NNT) was 18 (95% CI: 12 - 26) with risk of 72%.Conclusion: Prophylactic antibiotics for potensially infected newborn to prevent early-onset clinical neonatal sepsis did not result in significant different effect compared no prophylactic antibiotics.Keywords: no prophylactic antibiotics - early-onset neonatal sepsis - neonatal risk factors
The influence of non-selective and selective-COX-2 NSAIDs post-minor surgery for the turning of the bleeding time. Ishandono Dachlan, Ishandono Dachlan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 03 (2001)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: NSAIDs remain among the most widely prescribed drugs worldwide, including for surgical cases. Their action are primarily by inhibiting cyclo-oxigenase (COX), the key enzyme catalyzing the biosynthesis of prostaglandins (PGs). There are two similar but distinct isoforms of the enzyme - COX-1 and COX-2. One of the effects of COX-1 inhibition (nonselective NSAIDs) is decreasing thromboxanes, which is one of the important factors in thrombocytes aggregation and blood clotting. The optimal thrombocyte aggregation is required in many surgical cases, especially in microsurgery.Objective: The aim of this study is to compare the influence of non-selective and selective-COX-2 NSAIDs in the turning of the bleeding time.Methods: A prospective study of five days using NSAIDs has been done. The subjects were randomly distributed into two groups, non-selective group and selective COX-2 inhibitor group. The bleeding time was measured prior and after five days using of NSAIDs. The result was analyzed with t-test. Results: The mean of the prior bleeding time was 2.85 minutes (non-selective group) and 2.90 minutes (selective-COX-2 Inhibitor group). After five days using of NSAIDs, the bleeding time was increased from 2.85 to 3.15 minutes (non-selective group) and 2.90 to 2.95 minutes (selective COX-2 Inhibitor group). The mean of the bleeding time difference were 0.3 minutes (non-selective group) and 0.05 minutes (selective COX-2 Inhibitor group). T-test analysis showed that bleeding time was increased significantly from 2,85 minutes up to 3.15 minutes (p=0.005) after five days using non-selective NSAIDs, while there was no significant increase of bleeding time, from 2.90 minutes up to 2.95 minutes (p=0.591) after five days using of selective COX-2 inhibitor NSAIDs.Conclusion: Selective COX-2 inhibitor NSAIDs did not increase the bleeding time, while non-selective NSAIDs increased bleeding time after five days usage.Keyword: NSAIDs - selective - COX2 inhibitor - bleeding time - thromboxanes
The influence of non-selective and selective-COX-2 NSAIDs post-minor surgery for the turning of the bleeding time. Ishandono Dachlan, Ishandono Dachlan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 03 (2001)
Publisher : Journal of the Medical Sciences (Berkala ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (807.781 KB)

Abstract

Background: NSAIDs remain among the most widely prescribed drugs worldwide, including for surgical cases. Their action are primarily by inhibiting cyclo-oxigenase (COX), the key enzyme catalyzing the biosynthesis of prostaglandins (PGs). There are two similar but distinct isoforms of the enzyme - COX-1 and COX-2. One of the effects of COX-1 inhibition (nonselective NSAIDs) is decreasing thromboxanes, which is one of the important factors in thrombocytes aggregation and blood clotting. The optimal thrombocyte aggregation is required in many surgical cases, especially in microsurgery.Objective: The aim of this study is to compare the influence of non-selective and selective-COX-2 NSAIDs in the turning of the bleeding time.Methods: A prospective study of five days using NSAIDs has been done. The subjects were randomly distributed into two groups, non-selective group and selective COX-2 inhibitor group. The bleeding time was measured prior and after five days using of NSAIDs. The result was analyzed with t-test. Results: The mean of the prior bleeding time was 2.85 minutes (non-selective group) and 2.90 minutes (selective-COX-2 Inhibitor group). After five days using of NSAIDs, the bleeding time was increased from 2.85 to 3.15 minutes (non-selective group) and 2.90 to 2.95 minutes (selective COX-2 Inhibitor group). The mean of the bleeding time difference were 0.3 minutes (non-selective group) and 0.05 minutes (selective COX-2 Inhibitor group). T-test analysis showed that bleeding time was increased significantly from 2,85 minutes up to 3.15 minutes (p=0.005) after five days using non-selective NSAIDs, while there was no significant increase of bleeding time, from 2.90 minutes up to 2.95 minutes (p=0.591) after five days using of selective COX-2 inhibitor NSAIDs.Conclusion: Selective COX-2 inhibitor NSAIDs did not increase the bleeding time, while non-selective NSAIDs increased bleeding time after five days usage.Keyword: NSAIDs - selective - COX2 inhibitor - bleeding time - thromboxanes
Prognostic significance of argyrophilic nucleolar organizer region (AgNOR) counts and nutritional status in pediatric acute lymphoblastic leukemia (ALL). Wisman Herminto, Wisman Herminto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 03 (2001)
Publisher : Journal of the Medical Sciences (Berkala ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (146.492 KB)

Abstract

Background: The cell proliferation rate is a well-established prognostic factor in cancer, but it has not been considered as a prognostic factor used to stratify ALL patients into risk groups.Objective: The main goal of this study was to verify the relationship between AgNOR number and nutritional status, at the time of diagnosis, and remission induction response rate and survival in ALL patients. Methods: Smears of marrow aspirates from 35 newly diagnosed and previously untreated ALL patients were stained, at presentation, by silver method and evaluated by counting the mean AgNOR number of each case. Anthropometric nutritional status was obtained also for each patient.Results: The mean AgNOR number of the whole series was 3.54 ± 0.74. It was significantly higher in resistant patients than in patients who achieved complete remission (p = 0.01). It was found that the mean AgNOR number = 4 was related to the lower remission induction response than the mean AgNOR number < 4 (p = 0.02). Multivariate analysis by Cox regression model showed that the mean AgNOR number retained its prognostic significance as a predictor of survival (p = 0.04). Conversely, nutritional status was not correlated with remission induction response, and was not of prognostic significance, either.Conclusion: AgNOR number at diagnosis is a reliable prognostic parameter to predict remission induction response rate and survival in childhood ALL, and should be rountinely introduced in the group risk definition.Keywords: AgNOR - nutritional status - prognostic factor - pediatric ALL
The relationship between p53 expression, cell proliferation index and epidermal thickness in psoriasis Sekar Djatiningrum, Sekar Djatiningrum
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 03 (2001)
Publisher : Journal of the Medical Sciences (Berkala ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (105.334 KB)

Abstract

Background: The specific process among psoriatic lesions is keratinocyte hyperproliferation state, and one of the genes that controls cell cycle is wild type of p53 gene. The correlation between p53 overexpression and psoriatic keratinocytes hyperproliferation has not been established yet. Objective: To clarify the relationship between p53 overexpression and psoriatic keratinocyte proliferation index, as well as the epidermal thickness resulted from this proliferation.Methods: 50 paraffin-embedded tissue sections were chosen from block collection of Pathologic Anatomy Department. The p53 overexpression was measured by counting the number of positive cell among 500 cell stained by antibody anti p53. The cell proliferation index was measured by counting the number of black dot among 100 epidermal cells stained by silver nitrate. The epidermal thickness, represented by the thickness of epidermal rete ridges was measured by using calibrated micrometer in hematoxillin stained section.Results: p53 expression was significantly correlated in fairly degree with cell proliferation index (r, = + 0,47; P < 0,001) and significantly correlated in moderately degree with epidermal thickness (r, = + 0,57; P < 0,001). Cell proliferation index was significantly correlated in fairly degree with epidermal thickness (r1 = + 0,37; P < 0,004).Keywords: psoriasis - p53 - cell proliferation index - Ag NOR - epidermal thickness

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