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Articles 14 Documents
Search results for , issue "Vol 39, No 02 (2007)" : 14 Documents clear
The Effect of Narrow and Broad Band Ultraviolet B Onto Keloid Fibroblast-VEGF Expressions Ishandono Dahlan, Yohanes Widodo Wirohadidjojo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 39, No 02 (2007)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Collagenase inactivation of keloid lesions is due to plasminogen activator inhibitors which are synthesized under stimulation of vascular endothelial growth factor (VEGF), a released protein under hypoxia conditions. On the other hand, ultraviolet B (UVB) may generate various oxidative molecules of irradiated chromophores. The effect of UVB in VEGF synthesis is unclear.ObJective. To know the effect of narrow and broad band ultraviolet-B on keloid fibroblast-VEGF expression. Materials and methods: Materials in this study were keloid materials collected from dermatosurgery and plastic surgery keloid revision. A parallel simple experiment study was performed to compare the effect of 0, 50, 75, and 100mJ/cm2 of broad band (BBUVB) as well as narrow band UVB (NBUVB) in VEGF synthesis of passage-3 keloid fibroblasts isolated from 4 patients. Samples were stained with monoclonal antibody anti VEGF. The selected DAB-brown colors of cytoplasm were computed based on Photoshop software histogram.Results: Compared to untreated group, all of various NBUVB showed a very significant (P0.05) between NBUVB and BBUVB groups.Conclusion: NBUVB as well as BBUVB can suppress VEGF synthesis among irradiated keloid fibroblasts. The 50 mJ/cm2 of NB UVB as well as 75 mJ/cm2 of BBUVB may be developed as the modality in keloid prevention or treatment.Keywords: keloid-fibroblasts, broad-band UVB, narrow-band UVB, VEGF
Pigmented Gallstone in Children With Thalassemia Syndrome Sustiyanto, Nenny SM Sumadiono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 39, No 02 (2007)
Publisher : Universitas Gadjah Mada

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Background: Pigmented gall stones in children frequently occur in spherocytosis and sickle cell anemia. The most common congenital hemolytic anemia in Indonesia is thalassemia. There is only a few studies concerning pigmented gall stones in thalassemia in the world and none in Indonesia. This study was aimed to know the prevalence of pigmented gall stones in patients with thalassemia in Pediatric Department of Dr. Sardjito Hospital.Materials and method: All patients with major thalassemia visiting Dr. Sardjito Hospital who consented to take part in the study underwent ultrasonography to identify the stone or sludge. As controls, children with no jaundice were examined.Results. There was 8,57% gallstone in thallasemia group and none in the control group.Conclusion: The occurrence of pigment gallstone in the thalassemia syndrome children in Yogyakarta the same as in other places. The risk factors of pigment gallstone should be investigated.Key words: gall stone - prevalence - thalassemia syndrome - ultrasonography.
The role of Various Factors in the Therapeutic Response of Calcipotriol in Mild to Moderate Plaque Type Psoriasis Patients Hardyanto Soebono, Siti Aminah Tri Susila Estri Sunardi Radiono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 39, No 02 (2007)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Psoriasis is a chronic skin inflammation and proliferation disease. Natural history of psoriasis depends on the genetic, age, sex, history of treatment and psychosocial stressor. Calcipotriol is suitable for long-term therapy with good efficacy and safety and clinical response variability but its activity is influenced by ultraviolet.Objective: To know the factors that may influence treatment response of calcipotriol ointment on mild to moderate plaque type psoriasis.Method: Longitudinal study of two times daily calcipotriol ointment 0.005% treatment in the psoriasis patients. Factors that may influence the natural course (age, sex, history of psoriasis in family, history of therapy, MED, working location and psychological stressor) were identified. Evaluation of therapy was performed in the 8th weeks and based on the PASI and PDI. Correlation between treatment responses with various factors were analyzed by using student t-test, Pearson and Spearman correlations and multiple linear regression.Result: At the end of study, PASI was shown to decrease 38.45%, while PDI was 28.70% (p
The Effect of Topical Extravirgin Olive Oil on Ultraviolet B-Induced 8-Hydroxy-2-Deoxyguanosine Formation in Human Skin Arief Budiyanto, Irianiwati, Catharina Sagita Yohanes Widodo Wirohadidjojo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 39, No 02 (2007)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Ultraviolet B (UVBI may cause DNA damage due to photooxydative reaction and form 8hydroxy-2-deoxyguanosine (8-0HdGI as a genotoxic product. Topically extra virgin olive oil (EVOOI can decrease 8-0HdG formation among UVB irradiated-hairless mice epidermal cells. Such effect in human skin has never been discovered.Objective: To know the effect of topically EVOO in UVB induced-8-0HdG formation in human epidermal cells.Method: A simple experiment was performed on cultured human foreskins. The foreskins were divided into 3 groups: group was treated with 100mJ/cm2 UVB + topical EVOO, group B with 100mJ/cm2 UVB, and group C as control. All skin was cultured in completed DMEM and fixation was performed at one and 24 hours. 8-0HdG expression was determined immunohistochemically with antibody anti 8-0HdG and measured based on histogram of selected colour of Adobe photoshop.Results: The mean of 8-0HdG expression in experimental groups: (8.02:t 13.81, (26.95:t 23.231. and 14.96:t 7.141, respectively (p =0.0001 at an hour; (14.91 :t30.63I, (37.58:t 25.631. and (8.76:t 10.941 respectively (p = 0.0001 at 24 hours.Conclusion: Extra virgin olive oil was proved to reduce the 8-0HdG formation in exposed human skin-UVB. and may be developed to be anti-photocarcinogenesis active ingredient topically.Kata kunci:Extra virgin olive oil, UVB, 8-OHdG, human Skin
Effect of C677T Mutation in Methiylenetetrahydrofolate Reductase Gene and Blood Folate on Hypertension Risk Mohammad Hakimi, Abdul Salam M Sofro, Sunarti Ahmad Husain Asdie
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 39, No 02 (2007)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Background: The prevalence of hypertension risk factor varies among race or ethnic groups. The varied prevalence is associated with culture or genetic differences or interaction between genetic and environment or nutrition factorsObjective: The aim of this study was to identify relationship between polymorphism of C677T in MTHFR gene and folate status towards the risk of hypertension among Javanese population.Methods: This study was case-control nested, in "Surveillance of Non-Communicable Diseases" in Purworejo, Central Java. The subjects were men with essential hypertension and 20-60 years old that had normal value of urine creatinine, blood glucose, cholesterol and triacylglycerol. They didnt take antihypertension drugs. The analysis of C677T polymorphism in MTHFR gene was done according to Frosst et al. (1995) method. The blood folate level was determined by Delfia-Folate Kit (PerkinElmer). The methods of Pfeiffer et al. (1999) was used to identify plasma total homocysteine level.Results: Odds ratio for subjects with CT genotype was 1.36 ICI: 95%:0.50;3.70); folate deficiency was 1.40 ICI: 95%:0.57;3.451; and both CT genotype and folate deficiency was 2.30 (CI: 95%:0.45;15.001. Homocysteine level of the cases with both folate deficiency and CT genotype was 45.28 .:!:. 30.39; and only folate deficiency was 17.94.:!:. 12.77; whereas in the control with both folate deficiency and CT genotype was 21.44.:!:. 10.71 and only folate deficiency was 11.79.:!:. 5.28.Conclusions: The effect of folate deficiency to homocysteine level and hypertension risk was slighly stronger than the genetic effect of C677T in MTHFR gene. In subjects with normal folate level, the CT genotype did not influence homocysteine level.Kata kunci:polymorphism, methylenetetrahydrofolate reductase, folate, hypertension
Pharmacokinetic profile of iron serum after ingestion of ferrous sulfate tablet 2 300 mg taken shortly after meal and 2 hours after meal in women with iron deficiency anaemia L.Hakim, E.Kristin M.Hakimi, S.K.Soejono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 39, No 02 (2007)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Iron supplementation is a common strategy used to control iron deficiency anaemia in developing countries. Despite of that, the prevalence of anaemia is still high. Several factors causing the failure of iron supplementation program were reported. The increase in haemoglobin concentration after iron supplementation was determined by several factors, that is, the dose, iron absorption, body iron store, diet, food, and pregnancy. There had been studies on iron pharmacokinetic profile after ingestion of iron tablet taken shortly after meal compared to 2 hours after meal in healthy women, but there was no study on women with iron deficiency anaemia.Aim: The aim of this study was to find out the effect of ferrous suphate @ 300 mg taken shortly after meal and 2 hours after meal on the iron pharmacokinetic profile in women with iron deficiency anaemia.Materials and method: This study was conducted with cross-over design, so that every subject had 2 interventions with an interval (washed-out period) of 7 days. In intervention 1, ferrous sulfate tablet @ 300 mg was taken shortly after meal, and in intervention 2, the tablet was taken 2 hours after meal. Serum samples were taken serially at 0, 0.25, 0.5, 1, 1.5. 2, 2.5, 3, 4, 6, 8, 10 and 12 hours after taking iron tablets. Ferric iron concentration in serum was determined by Vitros Fe Slides method, and iron pharmacokinetic profile was determined using non-compartmental method.Result: The values of pharmacokinetic parameter from the first and second interventions were compared by t test, and the result (mean:t SEMI were: Cmox 274.25 :t 28.18 and 232.92 :t 33.25 ug/dl, T mox 3.21:t 0.30 and 4.25 :t 0.64 hours, K.0.437 :t 0.0011 and 0.3808 :t 0.0065 hour" Kel 0.1375 :t 0.0132 and 0.1855 :t 0.0048 hour". T/2e 5.76 :t 0.74 and 5.81 :t 1.16 hours and AUCO-,2 2157.37 :t 264.55 and 1869.54 :t 330.60 ug/dl.hours. There are no significant differences in all pharmacokinetic parameters between both interventions.Conclusion: There are no differences in iron pharmacokinetic profiles after ferrous sulfate tablet @ 300 mg taken after meal and 2 hours after meal in women with iron deficiency anaemiaKata kunci:iron concentration, pharmacokinetics, ferrous sulfate, anemia, effect of food
The Evaluation of Vaginal Hysterectomy Using Spinal Anaesthesia Ibnu Pranoto, Ibnu Pranoto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 39, No 02 (2007)
Publisher : Universitas Gadjah Mada

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Abstract

Background. Vaginal hysterectomy can be performed on patient under general or spinal anesthesia. There are some advantages of spinal anesthesia compared to general anesthesia, although some prefer general anesthesia. We have done frequently vaginal hysterectomy using spinal anesthesia and we are reporting our experience.Objective:To know the spinal anethesia efficency compared to general anesthesia in terms of duration of vaginal hysterectomy operation, amount of bleeding and length of stay.Design: Cross sectional descriptive studySetting: Sardjito HospitalMaterials and methods: Patients underwent vaginal hysterectomy in Dr. Sardjito Hospital from March 2005 until February 2007Results: 50 patients underwent vaginal hysterectomy that consisted of 44 patients with spinal anesthesia and 6 patients with general anesthesia. Vaginal hysterectomy with spinal anesthesia had shorter duration of operation (1.93 hours) compared to general anesthesia (1.95 hours). Patients length of stay was shorter with spinal anesthesia (5.8 days) compared to general anesthesia (9 days). The average amount of blood loss in spinal anesthesia was (250.34 mil compared to general anesthesia (625.0 mil.Conclusion: This study suggests that spinal anesthesia reduces length of hospital stay and amount of blood loss in patients with vaginal hysterectomy compared to general anesthesiaKey Words: vaginal hysterectomy, spinal anesthesia, general anesthesia, duration of operation, amount of bleeding and length of stay.
The Evaluation of Vaginal Hysterectomy Using Spinal Anaesthesia Ibnu Pranoto, Ibnu Pranoto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 39, No 02 (2007)
Publisher : Journal of the Medical Sciences (Berkala ilmu Kedokteran)

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Abstract

Background. Vaginal hysterectomy can be performed on patient under general or spinal anesthesia. There are some advantages of spinal anesthesia compared to general anesthesia, although some prefer general anesthesia. We have done frequently vaginal hysterectomy using spinal anesthesia and we are reporting our experience.Objective:To know the spinal anethesia efficency compared to general anesthesia in terms of duration of vaginal hysterectomy operation, amount of bleeding and length of stay.Design: Cross sectional descriptive studySetting: Sardjito HospitalMaterials and methods: Patients underwent vaginal hysterectomy in Dr. Sardjito Hospital from March 2005 until February 2007Results: 50 patients underwent vaginal hysterectomy that consisted of 44 patients with spinal anesthesia and 6 patients with general anesthesia. Vaginal hysterectomy with spinal anesthesia had shorter duration of operation (1.93 hours) compared to general anesthesia (1.95 hours). Patients length of stay was shorter with spinal anesthesia (5.8 days) compared to general anesthesia (9 days). The average amount of blood loss in spinal anesthesia was (250.34 mil compared to general anesthesia (625.0 mil.Conclusion: This study suggests that spinal anesthesia reduces length of hospital stay and amount of blood loss in patients with vaginal hysterectomy compared to general anesthesiaKey Words: vaginal hysterectomy, spinal anesthesia, general anesthesia, duration of operation, amount of bleeding and length of stay.
The Effect of Narrow and Broad Band Ultraviolet B Onto Keloid Fibroblast-VEGF Expressions Ishandono Dahlan, Yohanes Widodo Wirohadidjojo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 39, No 02 (2007)
Publisher : Journal of the Medical Sciences (Berkala ilmu Kedokteran)

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Abstract

Background: Collagenase inactivation of keloid lesions is due to plasminogen activator inhibitors which are synthesized under stimulation of vascular endothelial growth factor (VEGF), a released protein under hypoxia conditions. On the other hand, ultraviolet B (UVB) may generate various oxidative molecules of irradiated chromophores. The effect of UVB in VEGF synthesis is unclear.ObJective. To know the effect of narrow and broad band ultraviolet-B on keloid fibroblast-VEGF expression. Materials and methods: Materials in this study were keloid materials collected from dermatosurgery and plastic surgery keloid revision. A parallel simple experiment study was performed to compare the effect of 0, 50, 75, and 100mJ/cm2 of broad band (BBUVB) as well as narrow band UVB (NBUVB) in VEGF synthesis of passage-3 keloid fibroblasts isolated from 4 patients. Samples were stained with monoclonal antibody anti VEGF. The selected DAB-brown colors of cytoplasm were computed based on Photoshop software histogram.Results: Compared to untreated group, all of various NBUVB showed a very significant (P0.05) between NBUVB and BBUVB groups.Conclusion: NBUVB as well as BBUVB can suppress VEGF synthesis among irradiated keloid fibroblasts. The 50 mJ/cm2 of NB UVB as well as 75 mJ/cm2 of BBUVB may be developed as the modality in keloid prevention or treatment.Keywords: keloid-fibroblasts, broad-band UVB, narrow-band UVB, VEGF
The role of Various Factors in the Therapeutic Response of Calcipotriol in Mild to Moderate Plaque Type Psoriasis Patients Hardyanto Soebono, Siti Aminah Tri Susila Estri Sunardi Radiono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 39, No 02 (2007)
Publisher : Journal of the Medical Sciences (Berkala ilmu Kedokteran)

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Abstract

Background: Psoriasis is a chronic skin inflammation and proliferation disease. Natural history of psoriasis depends on the genetic, age, sex, history of treatment and psychosocial stressor. Calcipotriol is suitable for long-term therapy with good efficacy and safety and clinical response variability but its activity is influenced by ultraviolet.Objective: To know the factors that may influence treatment response of calcipotriol ointment on mild to moderate plaque type psoriasis.Method: Longitudinal study of two times daily calcipotriol ointment 0.005% treatment in the psoriasis patients. Factors that may influence the natural course (age, sex, history of psoriasis in family, history of therapy, MED, working location and psychological stressor) were identified. Evaluation of therapy was performed in the 8th weeks and based on the PASI and PDI. Correlation between treatment responses with various factors were analyzed by using student t-test, Pearson and Spearman correlations and multiple linear regression.Result: At the end of study, PASI was shown to decrease 38.45%, while PDI was 28.70% (p

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