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Articles 10 Documents
Search results for , issue "Vol 51, No 3 (2019)" : 10 Documents clear
The role of transcatheter arterial chemoinfusion (TACI) in unresectable adenocarcinoma colorectal:a case report Poedjomartono, Bagaswoto; Pramiadi, P
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 3 (2019)
Publisher : Journal of the Medical Sciences (Berkala ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (356.765 KB) | DOI: 10.19106/JMedSci005103201910

Abstract

Colorectal cancer (CRC) is the fourth most common cancer in worldwide. In the last 10 years, the mortality rate of CRC decreased by more than 20% and 5-year survival remains approximately 60% due to the rising developments in diagnostic techniques and optimization of surgical, neoadjuvant and palliative therapies. We reported a case of 80-year-old woman with diarrhea, blood in the stool and weight loss for a year. The patient was diagnosed with colonic polyp eight years ago. In double-contrast barium enema (DCBE) showed filling defects in sigmoid with pedunculated form. Optical colonoscopy demonstrated tumor in sigmoid. Computed tomography (CT) abdomen showed circumferential thickening and luminal narrowing of sigmoid colon with stranding of the serosa and mesenteric fat as well as enlarge pericolic nodes without distant metastasis. Based on American Joint Committee on Cancer criteria the stage was T3N1M0. From histopathological diagnosis, the tumor was well differentiated adenocarcinoma. We concluded as unresectable adenocarcinoma colorectal. Patient received transcatheter arterial chemoinfusion (TACI) with oxaliplatin and bevacizunab in three courses every 2 months. After first TACI, symptoms and patient’s performance status improved without systemic side effects. Arteriography imaging showed decrease in tumor staining after third TACI. CT evaluation showed a significant decrease of tumor size, without nodal and distant metastasis.In this case, TACI treatment with oxaliplatin and bevacizumab in unresectable adenocarcinoma colorectaldemonstrated improvement of patient’s performance status, partial response, decrease stage and symptoms, without systemic side effects. It is proven that TACI treatment may be an effective palliative therapy for unresectable colorectal cancer. Further studies should be performed to verify these findings.We reported a case of a woman with unresectable adenocarcinoma colorectal showed good results after received TACI treatment.
The protective role of single bulb garlic (Allium sativum L.) towards foam cells and vascular cell adhesion molecules-1 (VCAM-1) on mice (Mus musculus) with high-fat diet Chasanah, Isfatun; Ghofur, Abdul; Lestari, Sri Rahayu
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 3 (2019)
Publisher : Journal of the Medical Sciences (Berkala ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (345.112 KB) | DOI: 10.19106/JMedSci005103201905

Abstract

 Atherosclerosis is initiated by inflammatory response characterized by the accumulation of lipids in the arteries, causing blockage of blood vessels. The excessive of low-density lipoprotein (LDL) in the blood is a major factor in endothelial dysfunction and results in an inflammatory process. The inflammatory process in atherosclerosis is due to the expression of adhesion molecules, vascular cell adhesion molecules-1 (VCAM-1). This research aimed to evaluate the effect of single bulb garlic oil extract (SGBOE) against VCAM-1 expression in high-fat diet mice. Thirty male mice strain Balb/C were acclimatized for one week. Mice were divided into 6 groups (n=5): normal, high-fat diet (HFD), HFD + simvastatin, and HFD + SBGOE 12.5, 25, and 50 mg/kg BW respectively. HFD was given for 45 days. The SGBOE was given for four weeks orally. The aortic VCAM-1 expression was assayed using the immunohistochemical-flouresencemethod. The result of One-Way ANOVA showed that the treatment influenced significantly (p<0.05). The foam cells increase in the high-fat diet group compared than normal mice. Dose 12,5 mg/kg BW reduces VCAM-1 expression near the normal group. Allicin and S-allyl cysteine (SAC) compounds in single bulb garlic are antioxidant compounds that act to prevent oxidative stress and prevention mechanisms against lipoprotein modification.
The role of genital tract infection inpreterm delivery: aretrospective study Susilawati, Tri Nugraha; Satria, Yohanes Aditya Adhi; Budihastuti, Uki Retno
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 3 (2019)
Publisher : Journal of the Medical Sciences (Berkala ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (300.648 KB) | DOI: 10.19106/JMedSci005103201904

Abstract

 Preterm delivery is associated with higher mortality and morbidity of neonates, also increasestheir risk of having growth and development impairment.This study aimed toidentify the role ofgenital tract infection in preterm delivery. A retrospective study was conducted on medical records of mothers who had preterm delivery in a tertiary hospital in Surakarta, Indonesia during 2017. The data collected were mothers’ age and their gestational age, the history of current pregnancy, the number of previous abortion(s), mothers’ body temperature, the extent of abnormal vaginal discharge, and laboratory findings (white blood cell count, platelet count, red blood cell count, hemoglobin count, hematocrit level, urinalysis and microbiology results). The statistical differences amongst categorical and numerical data were analyzed using the Chi-Square test and the Mann-Whitney test. Based on the patient’s history and the examination results, we suspected genital tract infections in22.52% (25/111)of subjects. All of them had abnormal vaginal discharge despite only one case had been confirmed as streptococcal infection. This study found that the majority of mothers with probable genital tract infection hadpreterm premature rupture of the membrane whilst preeclampsiawas more evident in those without genital tract infection. We conclude that genital tract infection during pregnancy is a significant contributor to the occurence of premature birth so that microbiological testing is needed to confirm the diagnosis.
The eyelid tumor in Yogyakarta, Indonesia Supartoto, Agus; Ayuningtyas, Annisa Nurina; Dibyasakti, Banu Aji; Utomo, Purjanto Tepo; Respatika, Datu; Sasongko, Muhammad Bayu
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 3 (2019)
Publisher : Journal of the Medical Sciences (Berkala ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (482.678 KB) | DOI: 10.19106/JMedSci005103201906

Abstract

Many types of eyelid tumors may easily be diagnosed from a clinical point of view. However only a small number of large studies exist exploring the frequency of eyelid lesions from different regions. According to the epidemiology of various eyelid lesions happened in Yogyakarta Special Region, this study was aimed to investigate the prevalence of eyelid tumors in Yogyakarta Special Region. A total of 94 patients were enrolled in a descriptive study. The data were taken retrospectively from the medical record. All patients were diagnosed with eyelid tumors from January 2014 until December 2017 by histopathological examination. Among the subjects, 56 (59.6%) were male and 38 (40.4%) were female. There was no difference found in laterality (OD 46% vs OS 50%). Sebaceous carcinoma was found in 15 (16%) patients, followed by squamous cell carcinoma (SCC) 13 (13.8%), basal cell carcinoma (BCC) 11 (11.7%), epidermoid cyst 7 (7.4%), non-Hodgkin lymphoma 7 (7.4%), and others. We also found that 11 (11.7%) of patients showed an inflammation appearance only. The therapy was varied from extirpation and biopsy (39.4%), wide excision (27.7%), excision and biopsy (18.1%), exenteration (10.6%), and also anterior and lateral orbitotomy (2.1%) for each procedure. The eyelid tumor was found equally in the right and the left eye. Sebaceous carcinoma followed by SCC and BCC were the most common eyelid tumor found in this study. A further study is needed to determine the risk factor of each tumor.
The effect of long-term high-fat diet in ovariectomized Wistar rat (Rattus norvegicus)study on lipid profile, endothelial nitric oxide synthase(eNOS) dan endhotelin-1 (ET-1) serum Sudarsono, Tantri Analisawati; Agustiningsih, Denny; Sunarti, S
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 3 (2019)
Publisher : Journal of the Medical Sciences (Berkala ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (226.572 KB) | DOI: 10.19106/JMedSci005103201902

Abstract

Accumulation of cholesterol in the blood will cause stiffness in arteries and trigger the formation of atherosclerotic lesions. Estrogen has a role as an antioxidant that can prevent the low density lipoprotein(LDL) oxidation. In menopause with high-fat diet, the decrease of estrogen levels will trigger cholesterol accumulation in the blood lead to endothelial dysfunction mediated by endotelin-1 (ET-1) and nitric oxide synthase (eNOS). This study aimed to investigate the effect of long-term high-fat diet on the lipid profile, serum eNOS and ET-1levels on ovariectomized rat. It was experimental using 28 female Wistar rat divided into 4 groups. Group 1 was ovariectomized mice and given a standard diet (OVX-SD), Group 2 was ovariectomized mice and given a high-fat diet (OVX-HFD), Group 3 was not ovariectomized mice and given a standard diet(SHAM-SD) group, and Group 4 was not ovariectomized mice and given a high-fat diet (SHAM-HFD).Lipid profile of blood samples was measured pre- and post-treatment, whereas serum eNOS and ET-1 levels were measured post-treatment using ELISA method. No significantly difference of lipid profileon OVX-HFD group compared to that OVX-SD was observed. The serum eNOSlevel on OVX-HFD(702.11±68.73 pg/mL) was significantly lower than that OVX-SD (857.18±118.08 pg/mL) (p<0.05). However, there was no significantly different of serum ET-1 levelbetween OVX-HFD group (299.14±146.61 pg/mL) compared to that OVX-SD (194.25±102.96 pg/mL) (p>0.05). In conclusion, the serum eNOS levelon ovariectomized rat with long-term high-fat diet is lower than that on ovariectomized rat with standard diet.
The accuracy of fine needle aspiration biopsy to diagnose breast neoplasm Felisha, Hifdza Faza; Rinonce, Hanggoro Tri; Anwar, Sumadi Lukman; Dwianingsih, Ery Kus
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 3 (2019)
Publisher : Journal of the Medical Sciences (Berkala ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (251.264 KB) | DOI: 10.19106/JMedSci005103201907

Abstract

Breast lump is a very common complaint among women, especially during the reproductive year. Fine needle aspiration biopsy (FNAB) is a less invasive procedure. It is usually performed as an initial diagnosis prior to the operative procedure. The accuracy of the FNAB in Indonesia needs to be elaborated. The study aimed to evaluate the sensitivity and specificity of FNAB in diagnosing breast neoplasm. This is a retrospective study with cross sectional design, involving 145 patients with breast lump who underwent FNAB and histopathology examination in Dr. Sardjito General Hospital, Yogyakarta, from 2012 to 2014. Data analysis showed that female to male ratio was 23. 2:1 commonly occurred at 41-50 years old. Forty-one cases (28.28%) diagnosed as a benign lesion with fibrocystic changes as the most frequentcase (11.19%). The malignant case was 104 cases (71.72%) with ductal carcinoma as the highest case (51.49%). FNAB achieved a sensitivity of 85.58%, a specificity of 100% and a total accuracy of 89.66% in determining the benign or malignant breast lump. The accuracy, sensitivity and specificity of FNAB in diagnosing ductal carcinoma were 83.58%, 85.51% and 81.54%, respectively. The accuracy, sensitivity and specificity of FNAB to diagnose fibrocystic changes lesion were 85.82%, 26.67% and 93.28%, respectively. FNAB can be used as an alternative diagnostic tool to diagnose breast neoplasm. It provides rapid, cheaper, effective, valuable, and less invasive procedure in diagnosis of breast lump. 
Effect of tagitinin C isolated from Tithonia diversifoli (Hemsley) A Gray on migration activity and TGF-β1 levels on keloid fibroblast Santi, Elvira; Wahyuningsih, Mae Sri Hartati; Budiyanto, Arief
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 3 (2019)
Publisher : Journal of the Medical Sciences (Berkala ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.706 KB) | DOI: 10.19106/JMedSci005103201901

Abstract

Keloid is the formation of excessive scar tissue characterized by fibroblast hiperproliferations and collagen deposits that are similar with cancer cells. Tagitinin C is proven can inhibit proliferation and deposition of keloids collagen fibroblast. However, the mechanism of action of tagitinin C in migration activities and TGF-β1 levels of keloid fibroblasts has not been proved, yet. This study aimed to investigate the effects of tagitinin C isolated from Tithonia diversifoli (Hemsley) on migration activity and TGF-β1 expression of keloid fibroblast. This was quasi experimental study with post test only controlled group design using keloid fibroblasts isolated from keloid patients. The migration activity were performed by scratch assay and TGF-β1 levels were measured using an ELISA kits. Isolate tagitinin C was more active inhibit fibroblast keloid migration compare to the control groups (p<0.05) after 48 h incubation. TGF-β1 levels after incubation with isolate tagitinin C was lower then control group (p<0.05). In conclusion, isolate tagitinin C can inhibit migration and reduce TGF-β1 levels on keloid fibroblast
The analysis of cell damage of liver and kidney among alcoholics in Yogyakarta, Indonesia Suhartini, S; Widagdo, Hendro; Nurhantari, Yudha; Wiraagni, Idha Arfianti
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 3 (2019)
Publisher : Journal of the Medical Sciences (Berkala ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (311.818 KB) | DOI: 10.19106/JMedSci005103201908

Abstract

Alcohol tends to disrupt the organs function of human body, even can cause serious and chronic damage. In Indonesia, the data on cell damage taken from organs including the livers and kidneys among alcoholics are still practically unknown. The aim of this study was to compare the differences of organs’ cell disturbance between alcoholics and non-alcoholics in Yogyakarta, Indonesia. A crosssectional study was conducted among 197 people in Yogyakarta, including 96 alcoholics and 101 non-alcoholics. The material of the study was taken from venous blood samples. A kinetic photometric test was conducted to obtain data on blood-chemical markers’ value of livers (SGOT, SGPT, and GGT), and kidneys (BUN and serum creatinine). The data werethen analyzed by Chi square test.From a total of 96 alcoholics, 83.6% are males and 16.4% are females who consumed alcohol for an average of 16 years, with 51.6% routinely consuming it daily. The kind of alcohol they consumed was single-brand (59.8%). Based on 25th percentile (GGT), on 50th percentile (SGOT, GGT), and on 75th percentile (SGPT, GGT), the alcoholics had higher proportion value of liver marker disturbance than non-alcoholics which was statistically significant (p<0.05). Based on the 50th and 75th percentiles, the alcoholics also had higher proportion value on kidney marker (BUN) damage than non-alcoholics which was statistically significant (p<0.05). There were significant differences in GFR values between males and females (p<0.05), males had kidney cell damage 7.9 times more than females. There was no significant difference in the value of GFR between alcoholics and non-alcoholics. In conclusion, the alcoholics hassignificantly higher proportion value of blood-chemical markers than that non-alcoholics. The GFR values between males and females are also significantly different, and males had kidney cell damage 7.9 times more than that of females.
Prediction model of dengue hemorrhagic fever transmission to enhance early warning system in Gergunung Village, Klaten District, Central Java Satoto, Tri Baskoro Tunggul; Dwiputro, Alfin Harjuno; Risdwiyanto, Rifa Nadhifa; Hakim, A. Ulil Fadli; Pascawati, Nur Alvira; Diptyanusa, Ajib
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 3 (2019)
Publisher : Journal of the Medical Sciences (Berkala ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (285.788 KB) | DOI: 10.19106/JMedSci005103201909

Abstract

The dengue virus that causes dengue hemorrhagic fever (DHF) in principle is transmitted to humans through the bites of Aedes sp. In Indonesia, the disease is endemic in most provinces, including in Gergunung Village in Klaten District, Central Java. The village has shown the highest incidence of DHF for the last 5 years. Changes in demographical conditions, environment, and climate condition are predictors of dengue fever. This study aimed to demonstrate the association among human behavioral variables, physical environmental factors, and climate elements with DHF transmission to develop active surveillance model of DHF outbreak by the analysis of potential predictors. The research was an observational analytic study with case control design. Study population was selected from households with DHF case in 2016 through 2017 and the controls with ratio of 1:2. In total, 34 households were labeled as case and 68 households were labeled as control. Data collection was performed by observations, direct measurements, and interviews. Data were analyzed using appropriate statistical analysis with probability value of p<0.05. The result showed that insecticide use, proper waste management, livestock breeding, presence of plastered floor, water-resistant walls, bedroom windows, doors, gutters, and open drainage system, all did not show association with DHF case occurrence (p>0.05). In contrast, houses closer to each other tended to have more DHF cases (p<0.05; OR: 2.96; 95% CI: 1.01–8.67). Physical environmental factors and climate elements did not demonstrate significant associations with DHF case occurrence in this study. Human behavioral variables, physical environmental factors, and climate elements may serve as potential predictors of DHF outbreak, hence should be put into the model to enhance early warning system.
Infective endocarditis as a morbidity predictor in patients who underwent mitral valve surgery Supomo, Supomo; Wagiyanto, Kelik; Nugraha, Aditya Agam
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 3 (2019)
Publisher : Journal of the Medical Sciences (Berkala ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (210.799 KB) | DOI: 10.19106/JMedSci005103201903

Abstract

Infective endocarditis (IE) often develops into rheumatic heart disease (RHD) that has many perioperative complications during the evolution of the disease. Cardiac surgery in patients with IE is often followed by post-operative morbidities that can decrease the quality of life. This study aimed to investigate the correlations between preoperative IE and the emergence of various morbidities in patients undergoing heart valve surgery. This was a cross-sectional study with secondary data analysis of the medical record in 60 patients with mitral valve surgery at Dr. Sardjito General Hospital, Yogyakarta from 2012 to 2017. As much as 30 of 60 patients were suffered IE before mitral valve surgery. The most common valve disease in the IE group was mitral stenosis (60%). IE was significantly associated with arrhythmia and cardiac event with p=0.002 (PR: 6.91), prolonged ICU stay with p=0.011 (PR: 5.68), prolonged ventilator use with p=0.015 (PR: 12.43) and severe pulmonary arterial hypertension (PAH) with p=0.033 (PR: 0.192) post mitral valve surgery. As many as 26 (87%) and 29 (96.7%) of patients with IE had a prolonged ICU stay and prolonged ventilator after mitral valve surgery respectively. The incidence of severe PAH postoperatively in the IE group was lower than in the non-IE group (10% vs 36.7%). IE was significantly associated with the increased risk of arrhythmia, prolonged ventilator use and prolonged ICU stay after mitral valve surgery

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