cover
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kota surabaya,
Jawa timur
INDONESIA
Jurnal Farmasi Sains dan Terapan
ISSN : 23388404     EISSN : -     DOI : -
Core Subject : Health,
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) is published twice a year, containing research articles, review, and short communication in pharmacy science field, including medicinal chemistry, analytical chemistry, biologjcal pharmacy, pharmaceutical sciences and clinical pharmacy research and practice of pharmacy in industry, clinic, and community practice, such as pharmacies, distributors, and pharmacy education.
Arjuna Subject : -
Articles 89 Documents
Bioaktivitas Produk Fermentasi Monascus Srianta, Ignatius; Widharna, Ratna Megawati; Kardono, Leonardus Broto S.
Jurnal Farmasi Sains dan Terapan Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2127.778 KB) | DOI: 10.33508/jfst.v1i1.2341

Abstract

Monascus-fermented product has been used traditionally in Asian countries as food and medicine. Traditionally, Monascus-fermented rice was produced with cultivate Monascus sp. on steamed rice medium. During fermentation, Monascus sp. produce various metabolites. Beside pigments, Monascus sp. also produces monacolin K, monascin, dimerumic acid, etc which possess positive health impacts. Recent studies reported that Monascus sp. could grow on non rice medium i.e. soybean, dioscorea, adlay etc. This paper is a review of bioactivities of Monascus-fermented products including anti-inflammatory, anti hypercholesterolemic, anti hyperlipidemia, anti hypertensive, antioxidant and anti diabetes activities.
Fraksinasi dan Identifikasi SenyawaAntioksidan pada Eksb-ak Etanol buah Goji beny(Lycium barbarum linn.) secaraKromatografi Kolom Albrian, Diga; Wijaya, Sumi; Setiawan, Henry Kurnia
Jurnal Farmasi Sains dan Terapan Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (973.676 KB) | DOI: 10.33508/jfst.v1i1.2346

Abstract

Goji berry fruit (Lycium barbarum), familia Solanac'eae, is a red berry fruit. The chemical compounds contained in this fruit are polysaccharides, zeaxanthin and beta-carotene. Activity of the chemical compounds is still considered as a family of antioxidant compounds, which are used as a medicine to cure the diseases caused by the presence of free radicals such a~ atherosclerosis, cancer, liver cirrhosis, hypertension and diabetes. The research will be carried on fractionation and identification of the ethanol extract of Goji berry fruit to obtain compounds that have antioxidant power using chromatographic column method and DPPH method. The isolated compounds will be identified using methods phytochemica/s screening, TLC, UV-Vis spectrophotometer and infrared spectrophotometer. The result showed that secondary metabolites of Goji berry fruit which are potential as antioxidant compound were flavonoid (flavono/s or flavones). The isolated compound had higher antioxidant activity compare to the ethanol extract of Goji berry fruit Flavonoids are the major compounds that have antioxidant capacity. Whereas, the ethanol fraction of Goji berry fruits has the best antioxidant activity than the ethanol extract Keywords: Antioxidant, Goji berry, DPPH and chromatographic column
Optimasi Formula Tablet Floating Metformin Hidroklorida Menggunakan Polimer Guar Gum Elim, Siska; Hadisoewignyo, Lannie; Sukarti, Emi
Jurnal Farmasi Sains dan Terapan Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (800.677 KB) | DOI: 10.33508/jfst.v1i1.2345

Abstract

Metformln hydrochloride Is an orally administered blguanlde derivative drug and functions as an anti hyperglycemic In patient with type 2 diabetes mellitus with bioavallablllty between 50-6096. Floating system Is the one method to enhance absorption and bioavallablllty of metformln hydrochloride. The purpose of this research was to determine the effect of guar gum concentration and concentration effervescent components and Interactions of both components on physical properties of tablets, floating lag time, floating time, and dissolution rate constant and get the optimum formula with drug release pattern according to zero order kinetics. In this research using factorial design with two factors Is concentrations factor of guar gum at 15-2096 and concentrations factor of effervescent components Is citric acid and sodium bicarbonate (1:1) at 5-1096. The method used Is direct compression method. Concentration of guar gum have a significant effect on floating lag time and dissolution rate constant but do not have a significant effect on tablet hardness. While the concentration of effervescent components not have a significant effect on tablet hardness and dissolution rate constant but a significant effect on floating lag time. Interaction between guar gum concentration and concentration effervescent components not have a significant effect on tablet hardness, floating lag time, and dissolution rate constant Based on Design - Expert program optimization, the optimum formula obtained Is formula with combination 19,596 guar gum concentration and 5,596 concentration effervescent components which resulting 11,43 Kp hardness, floating lag time 8,69 min and K dissolution 0,324 mUmln.
Pemodelan Interaksi Turunan Potensial Asam Benzoilsalisilat dengan Reseptor Enzim Siklooksigenase-2 Natalia, Ongki; Caroline, Catherine; Soekardjo, Bambang
Jurnal Farmasi Sains dan Terapan Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2356.408 KB) | DOI: 10.33508/jfst.v1i1.2344

Abstract

The research of synthesize and quantitative structure activity relationship of benzoyl salicylic acid derivatives for analgesic activity in mice had been done by Soekardjo et al. (2009). From the fourteen compounds that had been synthesized, it has been known that O-(3-chlorometilbenzoyl) salicylic acid had the best analgesic activity (EDso value was 15.7396 mg/kg) while the EDso value of acetyl salicylic acid was 3296 mg/kg. Therefore further studies were carried out to determine the interaction modelling of potential benzoy/saJicyJic acid derivatives with enzyme cyclooxygenase-2 receptor by using Glide (Schrodinger license). The result showed that the GScore of 0-(2-trifluoromethoxybenzoyl)salicylic acid: -9.97, 0-(2.4-dimethylbenzoyl)salicylic acid: -9.94, O-(2-fluorobenzoyl)saJicylic acid : -9.62 and 0-(2.3-dimethy/chlorobenzoyl)salicylic acid : -9.49 more active than O-(3-chloromethylbenzoyl)saJicylic acid (-9.48), which GScore of each compound less than 0-(3-chloromethylbenzoyl)salicylic acid that had been synthesized. 0-(2-trifluoromethoxybenzoyl)salicylic acid, 0-(2.4-dimethylbenzoyl)salicylic acid, O-(2-fluorobenzoyl) salicylic acid and O-(2.3-dimethylchlorobenzoyl) salicylic acid are compounds that have a good potency as an analgesic. Interaction of potential benzoy/salicy/lc acid derivatives with enzyme cyclooxygenase-2 receptor was on residues Tyrosine 385, Leusine 531, Tyrosine 355 dan Arginine 120.
Perbandingan Aktivitas Antibakteri 4-Metilpiperazin-N-Karbonil Ampisilin dengan Ampisilin Terhadap Micrococcus luteus dan Escherichia coli Pudjianto, Andreyanus Eko; Ervina, Martha; Caroline, Catherine; Soekardjo, Bambang; Foe, Kuncoro
Jurnal Farmasi Sains dan Terapan Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (819.005 KB) | DOI: 10.33508/jfst.v1i1.2342

Abstract

Piperacillin has antimicrobial action but it is not absorbed from gastrointestinal tract Therefore, it needs structure modification to increase its absorption while keeping its antimicrobial action. The 4-methylpiperazin-N-carbonyl ampicillin was the product of reaction between ampicillin and 4-methylpiperazin-N-carbonyl chloride using Schotten Baumann method. The aim of this research was to compare the antibacterial activity between 4-methylpiperazin-N-carbonyl ampicillin and ampicillin. The comparison test of antibacterial activity was done with Kirby-Bauer disk diffusion susceptibility method on Mueller-Hinton agar which had been inoculated with Micrococcus luteus and Escherichia coli. Based on orientation studies, concentration of 4-methylpiperazin-N-carbonyl ampicillin and ampiCillin were 0.5 ppm against Micrococcus luteus and 500 ppm against Escherichia collin order to get visible zone of inhibition. The results showed that 4-methylpiperazin-Ncarbonyl ampicillin had lower antibacterial activity than ampicillin which was showed by its zone of inhibition which was lower compared to ampicillin in inoculated agar media of Micrococcus luteus and Escherichia coli.
Uji Aktivitas Antibakteri dan Antikuorum Sensing Fraksi dari Ekstrak Etanol Daun Salam (Eugenia polyantha Wight.) Ardani, Yonas Bianityo; Soegianto, Lisa; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1153.419 KB) | DOI: 10.33508/jfst.v1i1.2343

Abstract

Eugenia polyantha is being used as empirical plant for antiseptic, anthelmintic, anesthetic, keratolytic and also has properties protein in bacterial cells. The antibacterial activity of extract of Eugenia polyantha has been proved in previous study, therefore this research was conducted to know the antibacterial and antiquorum sensing from fractions of ethanolic extract of Eugenia polyantha. The extraction was prepared by maceration and fraction was prepared by liquid-liquid fractionation method with n-hexane (non polar), ethyl acetate (semipolar) and water (polar). Bioautography method with thin layer chromatography and chloroform as mobile phase was conducted to determine the active fraction. The diameter of inhibition zone was measured or determined by diffusion method, while concentration of minimum inhibition (MIC) and bactericidal concentration (MBC) were determined using broth and agar dilution methods. Antiquorum sensing activity for P. aeruginosa was carried on, using pigment survey and motility method~ The antibacterial activities showed that ethyl acetate fraction 2596 gave diameter of growth inhibition zone greater than others, 1:1.48 mm against S. aureus and 9.03 mm against P. aeruginosa. The MIC of ethyl acetate fraction gave value of :1.56% against S. aureus and 12.5% against P. Aeruginosa, meanwhile the MBC was 3.1396 against S. aureus and more than 12.5% against P. aeruginosa. The result showed that ethyl acetate fraction has potential antiquorum sensing activity on concentration of 2.5 %. The active fraction of ethanolic extract of Eugenia polyantha which has antibacterial and antiquorum sensing activity was ethyl acetate fraction.
Formulasi Sediaan Krim Pelembab Ekstrak Air Buah Semangka (Citrullus lanatus) Ekayanti, Ni Luh Putu Serly; Darsono, Farida Lanawati; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan Vol 6, No 1 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (442.576 KB) | DOI: 10.33508/jfst.v6i1.2011

Abstract

Watermelon is a tropical fruit which rich of carbohydrates such as sucrose, glucose and fructose that can moisturized the skin. Carotenoids such as lycopene in watermelons can acts as an antioxidant which protected skin from free radicals. Moisturizer are preparations used to improve dry skin. These preparations may decrease the Trans Epidermal Water Loss (TEWL) by forming a thin layer of fat on the surface of the skin as a barrier and restore skin softness. Watermelon extracts in this study are formulated into moisturizing cream. This study aims to determine the effect of the increasing concentration of the watermelon extract against its physical quality, effectiveness, safety, acceptability and cream stability. The watermelon extract obtained using is fresh fruit juice thickened with waterbath thermostat temperature ≤ 800C. Watermelon extract concentration used was 10% (Formula 1), 20% (Formula 2) and 30% (Formula 30. Evaluation of the cream includes the physical quality test; effectiveness test which; safety test; acceptability test and stability test. The results of this study showed the increasing concentrations of watermelon extract affect the results of the evaluation of moisturizing cream were organoleptic, pH, viscosity, dispersive power, adhesion, water washing power, effectiveness, and aseptability. Preparations which have the best quality are formula 3 containing extract 30%.
Pembentukan Kokristal Katekin dengan Nikotinamida Bakhtiar, Amri; Gaesari, Sherly Rahmah; Zaini, Erizal
Jurnal Farmasi Sains dan Terapan Vol 2, No 2 (2015)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1366.084 KB) | DOI: 10.33508/jfst.v2i2.720

Abstract

Telah dilakukan pembuatan kokristal katekin-nikotinamida dan evaluasi kelarutannya dalam pelarut air. Kokristal dibuat dengan dua metode, yaitu rekristalisasi dengan penguapan pelarut etanol 96% menggunakan rotary evaporator (metode I) dan penguapan pelarut pada suhu ruang (metode II). Karakterisasi kokristal katekin-nikotinamida dilakukan dengan difraksi sinar-X, analisis termal DTA (Differential Thermal Analysis), FT IR (Fourier Transform Infra Red), dan SEM (Scanning Electron Microscopy), serta uji kelarutan dalam pelarut air menggunakan orbital shaker selama 24 jam. Penetapan kadar katekin dilakukan dengan metode KCKT (Kromatografi Cair Kinerja Tinggi) menggunakan fase gerak air-asetonitril-metanol-etil asetat-asam asetat glasial (89:6:1:3:1). Hasil difraktogram sinar-X pada kokristal metode I menunjukkan terbentuknya padatan amorf, sedangkan pada metode II menunjukkan terbentuknya fase kristalin baru (kokristal). Pada analisis termal menggunakan DTA terjadi perubahan titik lebur pada kokristal metode I maupun metode II yang berbeda dengan titik lebur katekin dan nikotinamida yang menunjukkan terbentuknya campuran eutektik. Pada analisis FT IR, baik kokristal metode I maupun metode II terjadi pergeseran bilangan gelombang dari spektrum katekin dan nikotinamida yang menunjukkan terbentuknya ikatan hidrogen antara gugus hidroksi fenol dari katekin dengan gugus amida dari nikotinamida. Dari hasil SEM, terlihat habit kristal dari kokristal metode I maupun metode II berbeda dibandingkan dengan habit kristal katekin maupun nikotinamida yang menunjukkan terbentuknya kokristal. Namun kelarutan kokristal katekin-nikotinamida metode I (132,17 mg/100 mL) maupun metode II (131,09 mg/100 mL) tidak berbeda nyata dengan kelarutan katekin (124,58 mg/100 mL). Kata kunci: kokristal, katekin, nikotinamida, kelarutan, KCKT.
Efek Antifertilitas Fraksi n-Heksana, Fraksi Kloroform, dan Fraksi Metanol Biji Pepaya (Carica papaya L.) Terhadap Tikus Jantan Galur Wistar Muslichah, Siti; ., Wiratmo
Jurnal Farmasi Sains dan Terapan Vol 2, No 2 (2015)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1223.165 KB) | DOI: 10.33508/jfst.v2i2.716

Abstract

Rendahnya partisipasi pria dalam program Keluarga Berencana disebabkan karena terbatasnya pilihan kontrasepsi untuk pria. Penelitian ini bertujuan untuk mengevaluasi potensi fraksi n-heksana, fraksi kloroform, dan fraksi metanol biji pepaya sebagai bahan kontrasepsi. Fraksi-fraksi tersebut diberikan secara oral dengan dosis masing-masing 100 mg/kgBB selama 20 hari. Sebanyak 20 ekor tikus jantan dengan berat badan 200-300 g berumur 2-2,5 bulan dikelompokkan menggunakan Rancangan Acak Lengkap. Hasil penelitian menunjukkan terjadinya penurunan jumlah, motilitas, viabilitas serta peningkatan abnormalitas spermatozoa yang signifikan dibandingkan kontrol. Hasil tersebut menunjukkan bahwa ekstrak biji C. papaya mempunyai efek terhadap reproduksi pria yang menunjukkan potensi tanaman ini sebagai pengatur kesuburan pria. Kata kunci: biji Carica papaya, motilitas sperma, jumlah sperma, antifertilitas, abnormalitas sperma.
Uji Aktivitas Antidiabetes Ekstrak Air Kelopak Bunga Rosella (Hibiscus sabdariffa L.) pada Tikus dengan Metode Induksi Aloksan Dianasari, Dewi; Fajrin, Fifteen Aprila
Jurnal Farmasi Sains dan Terapan Vol 2, No 1 (2015)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (280.649 KB) | DOI: 10.33508/jfst.v2i1.812

Abstract

Salah satu jenis tanaman yang diduga memiliki khasiat sebagai antidiabetes adalah Rosella (Hibiscus sabdariffa L.) yang termasuk dalam famili Malvaceae. Kelopak bunga Rosella (Hibiscus sabdariffa L.) mengandung senyawa flavonoid khususnya antosianin dan vitamin C sebagai antioksidan yang mampu menetralisir radikal bebas yang menjadi salah satu penyebab diabetes dan mengurangi komplikasi penyakit tersebut. Tujuan dari penelitian ini adalah untuk menguji aktivitas antidiabetes dari ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) dan untuk mengetahui aktivitas antidiabetes pada ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) pada dosis yang berbeda (250 mg/kgBB, 500 mg/kgBB, dan 750 mg/kgBB). Metode penelitian yang digunakan adalah dengan cara induksi aloksan. Hasil penelitian menunjukkan bahwa kelompok uji ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) dosis 500 mg/kgBB dan 750 mg/kgBB memiliki aktivitas antidiabetes yang sebanding dengan kontrol positif yaitu Glibenklamid dengan dosis 0,45 mg/kgBB, sedangkan kelompok uji ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) dosis 250 mg/kgBB tidak menunjukkan aktivitas antidiabetes yang berarti karena tidak ada perbedaan yang bermakna dengan kontrol negatif (aquadest 5 mL/kgBB).