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Global Medical & Health Communication (GMHC)
ISSN : 23019123     EISSN : 24605441     DOI : -
Core Subject : Health,
The Global Medical & Health Communication (GMHC) is journal that publishes research articles of medical and health published every 4 (four) months (April, August, and December). Articles are original research that needs to be disseminated and written in English. Subjects suitable for publication include, but are not limited to the following fields of anesthesiology and intensive care, biochemistry, biomolecular, cardiovascular, child health, dentistry, dermatology and venerology, epidemiology, geriatric, histopathology, internal medicine, nutrition, obstetrics and gynecology, occupational health, ophthalmology, oral biology, orthopedics and traumatology, otorhinolaryngology, pharmacology, pharmacy, preventive medicine, public health, pulmonology, radiology, and reproductive health.
Arjuna Subject : -
Articles 227 Documents
THE RELATIONSHIP BETWEEN D-DIMER LEVEL WITH CEREBRAL VENOUS SINUS THROMBOSIS (CVST) OCCURANCE USING DIGITAL SUBTRACTION ANGIOGRAPHY (DSA) IN RSUP DR. HASAN SADIKIN BANDUNG Putra, Afdi Arahim; Buchori, Eppy; Hilman, Hilman; Amalia, Lisda
Global Medical & Health Communication (GMHC) Vol 7, No 3 (2019)
Publisher : Faculty of Medicine Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v7i3.5341

Abstract

Cerebral Venous Sinus Thrombosis (CVST) is a cerebrovascular disease in the form of occlusion due to thrombus in the venous and cerebral sinuses which rarely occurs with varied clinical symptoms and radiological features and very difficult to diagnose. D-Dimer can be used as a diagnostic marker for cases of venous thromboembolism, with sensitivity of around 90-92%, but the specificity is not too high (70-73%) because it can also increase in other condition. Digital Subtraction Angiography (DSA) is a gold standard examination to establish the diagnosis of CVST. The purpose of this study was to determine the relationship between D-Dimer level and CVST using DSA at Dr Hasan Sadikin Hospital in Bandung. This study used an observational analytic method with case-control study design using retrospective data from medical records at Dr Hasan Sadikin Hospital from January 2017- August 2019. The research subjects were divided into 2 groups, namely the high D-Dimer levels and the normal/low D-dimer levels. There are 40 people who meet the inclusion criteria, ages averaging from 44.77±14.399 years and consists of 9 male patients (22.5%) and 31 women patients (77.5%). For normal/low D-Dimer levels 20 patients (50.0%) and high D-Dimer levels 20 patients (50.0%). Statistical test results measuring D-Dimer and CVST levels found a significant relationship (p <0.05). In conclusion, there is a relationship between D-dimer levels with CVST events that have been done by DSA. The higher the D-dimer level, the higher the suspicion of CVST.
IMPLEMENTATION OF SUSTAINABLE DEVELOPMENT GOALS (SDGS) AND DISASTER RISK REDUCTION (DRR): A CASE STUDY Davey, Peter
Global Medical & Health Communication (GMHC) Vol 7, No 3 (2019)
Publisher : Faculty of Medicine Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v7i3.5497

Abstract

Climate change adaptation and mitigation measures a complicated process and community livelihoods are being seriously impacted. The current local community reality is that climate change and associated disasters are becoming more intense, unpredictable, frequent and costly impacting on rural and urban areas. Disaster Risk Reduction is very important. United Nations General Assembly already set the global policy with the hope that the impact of future disaster events on the community is substantially reduced. Solutions to internal refugee crises start at the local level and require that everyone plays a part: every city, every neighbourhood including farming areas, and every individual can contribute. Leaders must create spaces where everyone can live in safety, become self-reliant, and contribute to and participate in their local community, and not allow people to shift into slum areas after disasters strike. The UNISDR suggests community?s use of the recovery, rehabilitation and reconstruction phases after a disaster to increase the resilience of nations and communities; through integrating disaster risk reduction measures into the restoration of physical infrastructure and societal systems, and into the revitalization of livelihoods, economies, and the environment.
VEGF-A AND PD-L1 IMMUNOEXPRESSION ASSOCIATION WITH MENINGIOMA HISTOPATHOLOGY GRADE Yunnica, Yunnica; Afiati, Afiati; Usman, Hermin Aminah; Hernowo, Bethy S.
Global Medical & Health Communication (GMHC) Vol 7, No 3 (2019)
Publisher : Faculty of Medicine Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v7i3.4202

Abstract

Histopathology grade of meningioma is one of the most common factors determining the prognosis. That affects the risk of recurrence and aggressiveness of the tumor. Biological factors related to histopathological grade are vascular endothelial growth factor (VEGF-A) and programmed death-ligand1 (PD-L1). This research aimed to understand the association between VEGF A and PD-L1 with meningioma histopathology grade. This is In-vivo research on 60 paraffin blocks of meningioma cases at the Hasan Sadikin Hospital, Bandung. Paraffin block samples consist of grade I (30), grade II (15), and grade III (15) meningioma. Immunohistochemical (IHC) staining of VEGF-A and PD-L1 performed to all samples. Data analyzed using the chi-square test with SPSS 24.0 for Windows. The result shows a statistically significant association between VEGF-A and PD-L1 immunoexpression with meningioma histopathology grade . PD-L1 is the most potent factor that influenced the histopathology grade of meningioma. The study concluded that the histopathology grade of meningiomas influenced by angiogenesis and immune checkpoints. VEGF A and PD-L1 immunoexpression in meningioma considered as a factor that influence the aggressiveness of meningioma
ANTIOXIDANT AND ANTI-TYROSINASE ACTIVITIES OF ALOE VERA RIND AND GEL EXTRACTS Mahadi, Sonya Bonifacia; Handayani, Rr. Anisa Siwianti; Widowati, Wahyu; Wilsen, Wilsen; Dewani, Yunita; Fachrial, Edy; Lister, I Nyoman Ehrich
Global Medical & Health Communication (GMHC) Vol 7, No 3 (2019)
Publisher : Faculty of Medicine Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v7i3.4453

Abstract

Aging is a natural process in human that can be characterized by the appearance of black spot on the skin due to hyperpigmentation. Aging may occur due to an excessive amount of free radicals in the body. Antioxidants possess ability to capture free radicals and inhibit tyrosinase which induces skin aging. Aloe vera has been used in traditional medicine because it contains several bioactive compounds that act as antioxidant and prevent aging process. This study aims to determine phytochemical content, antioxidant activity and tyrosinase inhibition activity of Aloe vera rind (AVRE) and gel (AVGE) extract. This research was carried out at Aretha Medika Utama-Biomolecular and Biomedical Research Center in Bandung city in September-November 2018. Phytochemical assay was determined using modified Farnsworth method. Antioxidant assay was determined using DPPH scavenging activity and antiaging assay was obtained using tyrosinase inhibition assay. AVRE contains flavonoid, phenol, steroid, and alkaloid. Meanwhile, AVGE contains steroid and alkaloid. IC50 DPPH scavenging activity of AVRE was 113.18 µg/mL followed by AVGE was 291.96 µg/mL. IC50 tyrosinase inhibition activity of AVRE was 65.04 µg/mL followed by AVGE was 111.89 µg/mL. AVRE had more active DPPH scavenging activity and tyrosinase inhibition activity than AVGE.
EFFECT OF INTEGRATED REPRODUCTIVE HEALTH MODULE IMPLEMENTATION ON JUNIOR HIGH SCHOOL STUDENT BEHAVIOR CHANGE Handayani, Dini Saraswati; Mandiri, Ariyati; Aprillani, Irna Kurnia
Global Medical & Health Communication (GMHC) Vol 7, No 3 (2019)
Publisher : Faculty of Medicine Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v7i3.3202

Abstract

Socio-cultural changes, low understanding of religion, development of information technology, and limited sources of appropriate information, causes of sexual and reproductive behavior problems in adolescents. The solutions is through the application of integrated reproductive health module as a teaching guide for teachers in which there are learning achievements, materials, and systematic and interesting learning method by using student center learning approach. The objectives of this study is to analyze the implementation effect of integrated reproductive health learning module on changes in student behavior, using quasi experimental pre-post test design with control groups. The sample in this research is the students of class VII in 5 (five) Bandung City areas in accordance with inclusion and exclusion criteria. A total of 36 students from the five junior secondary schools as the treatment group received an integrated learning module, while 38 students from different classes in the same school as the control group using reproductive health based on the Curriculum 2013. The data collection used questionnaires to assess behavior based on self-assessment , friends and parents. The results of this study indicate that the interpersonal  communication behavior increased by  5.74%, reproductive health behavior increased by 18.65% and sexual behavior increased by 9.07%, with a significant differences compared to students who received the 2013 curriculum (p <0.001). The conclusion of this research that the implementation of integrated reproductive health learning module in teacher has an effect on the behavior change of students in maintaining reproductive health, sexual and interpersonal communication.
PHYLOGENETIC ANALYSIS OF CULEX TRITAENIORHYNCHUS AND CULEX VISHNUI VECTOR OF JAPANESE ENCEPHALITIS VIRUS Astuti, Raden Roro Upiek Ngesti Wibawaning; Mulyaningsih, Budi; Soesilohadi, R.C. Hidayat; Nurcahyo, Raden Wisnu; Hadisusanto, Suwarno
Global Medical & Health Communication (GMHC) Vol 7, No 3 (2019)
Publisher : Faculty of Medicine Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v7i3.4051

Abstract

Culex tritaeniorhynchus and Culex vishnui are medically important mosquitoes that transmit Japanese Encephalitis (JE) virus. There is less information about the recording data and research due to genetic character differences among them. The objective of this study was to examine the genetic variation of Cx. tritaeniorhynchus and Cx. vishnui in 3 site of Central Java using PCR-RAPD.  The study was done from January to November 2017, in Pekalongan City, Pekalongan Regency and Semarang Regency. Adult female mosquitoes were collected by landing bite method. DNA of ten Cx. tritaeniorhynchus  samples and fifteen samples of Cx. vishnui were purified using  DNA kit extraction. Furthermore, PCR amplification was conducted with 5 RAPD primers (OPA 11, 12, 15, 16, and 20) and would run into 2% gel electrophoresis for 45 minutes. Cluster analysis was done by using MVSPTM software. The results showed  213 genetical characters of Cx. vishnui, while 142 characters were shown by Cx. tritaeniorhynchus. The dendograms showed 3 distinct grups of Cx. vishnui from 2 sites of Pekalongan and 1 site of Semarang, while Cx. tritaeniorhynchus showed 2 distinct grups, which were 1 group from Pekalongan and 1 group  from Semarang. Low genetic similarity (<10%) was shown Cx. vishnui from Pekalongan City and Pekalongan District, and there was no genetic similarity in Cx. tritaeniorhynchus from Pekalongan and from Semarang. It is concluded that the polymorphism of Cx tritaeniorhynchus and Cx. vishnui reached 100%.
RELATION BETWEEN VITAMIN D LEVEL AND KNOWLEDGE AND ATTITUDE TOWARDS SUNLIGHT EXPOSURE AMONG ASTHMA OUTPATIENTS IN SURABAYA Lorensia, Amelia; Suryadinata, Rivan Virlando; Amir, Gebriella Ayuni
Global Medical & Health Communication (GMHC) Vol 7, No 3 (2019)
Publisher : Faculty of Medicine Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v7i3.3094

Abstract

Asthma has become one of the health problems in the world. Asthma is characterized by chronic inflammation of the respiratory tract which leads to breathlessness, wheezing, and airflow limitation. Inflammatory reaction in asthma is related to inadequate vitamin D level. Vitamin D is a vitamin produced naturally by the body when exposed to sunlight that has immunomodulatory properties can reduce inflammation. Knowledge and positive attitude to sun exposure are necessary to prevent severe asthma attacks. This was a cross-sectional study involving 26 subjects in a private university in east Surabaya during January?June 2017 that was aimed to determine the relation between vitamin D and knowledge and attitude towards sunlight exposure. Data were collected by measuring the vitamin D level in blood serum and through the use of a questionnaire that consisted of two aspects, level of knowledge and attitude to sun exposure. Chi-square test was used to analyze the relationship between vitamin D level, knowledge, and attitude. No relationship was found between blood vitamin D level of asthma respondents and level of knowledge of sun exposure related to vitamin D (p=0.444, p>0.05). The same was also true for the relationship between blood vitamin D level of asthma respondents and attitude to sun exposure related to vitamin D (p=0.768, p>0.05). The closeness of the relationship between knolwedge and attitude was also relatively low (0.093). In conclusion, there is no correlation between vitamin D level, knowledge, and attitude. In addition, there is also no correlation between knowledge and attitude with low relationship between the two variables. HUBUNGAN KADAR VITAMIN D DENGAN PENGETAHUAN DAN SIKAP TENTANG PAPARAN SINAR MATAHARI PADA PASIEN ASMA RAWAT JALAN DI SURABAYAAsma telah menjadi masalah kesehatan di dunia. Asma ditandai oleh peradangan kronis pada saluran pernapasan yang menyebabkan sesak napas, mengi, dan keterbatasan aliran udara. Reaksi peradangan pada asma terkait dengan kadar vitamin D yang tidak memadai. Vitamin D merupakan vitamin yang diproduksi secara alami oleh tubuh ketika terkena sinar matahari yang memiliki sifat imunomodulator dapat mengurangi peradangan. Pengetahuan dan sikap positif terhadap paparan sinar matahari diperlukan untuk mencegah risiko keparahan asma. Penelitian ini menggunakan metode cross-sectional yang melibatkan 26 subjek di sebuah universitas swasta di Surabaya Timur pada Januari?Juni 2017 yang bertujuan menentukan hubungan vitamin D dengan pengetahuan dan sikap terhadap paparan sinar matahari. Data dikumpulkan dengan mengukur kadar vitamin D dalam serum darah dan melalui penggunaan kuesioner yang terdiri atas dua aspek, tingkat pengetahuan dan sikap terhadap paparan sinar matahari. Uji chi-square digunakan untuk menganalisis hubungan antara kadar vitamin D, pengetahuan, dan sikap. Tidak ada hubungan yang ditemukan antara kadar vitamin D darah responden asma dan tingkat pengetahuan paparan sinar matahari yang terkait dengan vitamin D (p=0,444; p>0,05). Hal yang sama juga berlaku untuk hubungan antara kadar vitamin D darah responden asma dan sikap terhadap paparan sinar matahari yang terkait dengan vitamin D (p=0,768; p>0,05). Kedekatan hubungan antara pengetahuan dan sikap juga relatif rendah (0,093). Simpulan, tidak ada hubungan antara kadar vitamin D, pengetahuan, dan sikap. Selain itu, juga tidak ada hubungan yang rendah antara pengetahuan dan sikap.
Hubungan Antara Reactive Oxygen Species (ROS), Superoxide Dismutase (SOD) dengan Protein α-Sinuklein-larut Air pada Batang Otak Tikus yang Diinduksi Rotenon Yulianti, Arief Budi; Sumarsono, Sony Heru; Ridwan, Ahmad; Yusuf, Ayda T
Global Medical & Health Communication (GMHC) Vol 3, No 2 (2015)
Publisher : Fakultas Kedokteran Universitas Islam Bandung

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Abstract

Abstrak Parkinson adalah salah satu penyakit neurodegeneratif dengan ganggunan gerak bila kematian neuron dopaminergik lebih dari 70 %. Paparan neurotoksin diduga menjadi penyebab terjadinya Parkinson sporadik. Tujuan penelitian ini adalah menentukan kondisi stres oksidatif pada batang otak tikus Wistar yang diinduksi rotenon. Metode: Penelitian eksperimental dengan menggunakan tikus Wistar jantan. Variabel bebas: kelompok tikus, lama perlakuan, waktu pengamatan, dan lokasi di batang otak. Variabel terikat: konsentari SOD, konsentrasi protein α-sinuklein-larut air, dan densitas ROS. Densitas ROS berbeda secara signifikan antara kelompok perlakuan (sig: 0,029), waktu pengamatan (sig: 0,0001), dan lokasi di batang otak (sig: 0,001). Konsentrasi SOD tidak berbeda secara signifikan antar kelompok perlakuan (sig:0,566), waktu pengamatan (sig:0,441) dan lokasi di batang otak (sig: 0,091). Konsentrasi protein α-sinuklein-larut air berbeda secara signifikan antar kelompok perlakuan (sig: 0,001), waktu pengamatan (sig: 0,001) tetapi tidak berbeda secara signifikan pada lokasi di batang otak (0,625). Densitas ROS relatif tertinggi pada hari ke-10 dan 40. Sementara itu konsentrasi SOD pada hari ke-10 dan 40 relatif rendah sedangkan konsentrasi protein α-sinuklein-larut air pada hari ke-10 relatif tinggi dibandingkan dengan hari ke-40. Dengan demikian dapat disimpulkan bahwa stres oksidatif pada batang otak tikus Wistar yang diinduksi rotenon berpengaruh pada struktur protein α-sinuklein.   Kata kunci: Batang otak, protein α-sinuklein, ROS, rotenon, SOD, stres oksidatif   Abstract Parkinson is the neurodegenerative disease with movement disordered, if the dopaminergic neurons dead more than 70%. Neurotoxins exposure is predicted cause sporadic Parkinson. The research aim is to determine oxidative stress stage in the brainstems Wistar rat’s treated-rotenone. Methods: An experimental study using male Wistar rats. The independent variable: groups of rats, long treatment, observation time, and location in the brainstem. The dependent variable: SOD concentration, concentration of protein α-synuclein-water soluble, and ROS density. ROS density significantly different among treatment groups (sig: 0,029), observation time (sig: 0.0001), and the location in the brainstem (sig: 0,001). SOD concentrations not significantly different among treatment groups (sig: 0.566), observation time (sig: 0.441) and the location in the brainstem (sig: 0.091). The concentration of protein α-synuclein-water soluble significantly different among treatment groups (sig: 0,001), observation time (sig: 0,001), but not significantly different at the location in the brainstem (0,625). ROS density relatively high at day 10 and 40. Meanwhile SOD concentration on day 10 and 40 are relatively low. And the concentration of α-synuclein protein-water soluble on day 10 is relatively higher than on day 40. The conclution is oxidative stress in the brainstem Wistar rat’s treated-rotenone effected on the protein α-synuclein structure Key word: α-synuclein protein, brainstem, oxidative stress, ROS, rotenone, SOD
Exploration of Methadone and HIV Treatment For Injecting Drug Users In West Java, Indonesia: Lessons from Practice Laere, Igor van; Hidayat, Teddy; Wisaksana, Rudi
Global Medical & Health Communication (GMHC) Vol 1, No 1 (2013)
Publisher : Fakultas Kedokteran Universitas Islam Bandung

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Abstract

ABSTRACT Over the last decade, Indonesia became one of the fastest growing injecting drug user (IDU) driven HIV epidemics in Asia. Among strategies to prevent and control the HIV epidemic in Indonesia, methadone maintenance treatment (MMT) has been established and could become an entry point for HIV testing and treatment in IDUs. This study explored MMT and HIV treatment practices in West Java. An evaluation team visited six MMT clinics, interviewed staff and collected data on patient characteristics, methadone dose, and HIV testing and treatment practices. By October 2011, from 203 IDUs entering MMT (range 7-73 per clinic), 95% were male with the average age of 31 years (range 19-60 years), 92% had a senior high school or higher diploma, 47% had a regular income, and 55% were married. The mean methadone dose was 79 mg/day (range 13-208mg/day). About 85% of the MMT patients were tested for HIV, of whom 70% were found HIV positive (121/173), while 59% had a baseline CD4 count &gt; 200 cells/mm3 and 65% were receiving ART.  In conclusion, few IDUs entered MMT in West Java and among those who did; high HIV and ART rates were reported, stressing the need for active linking between harm reduction services and integrated MMT and HIV treatment for IDUs.   Key words: injecting drug user; methadone; HIV; ART; clinical guideline; Indonesia
Knowledge about Byssinosis and the Use of Face-Masks Respati, Titik; Ibnusantosa, Ganang; Rachmawati, Meike
Global Medical & Health Communication (GMHC) Vol 1, No 1 (2013)
Publisher : Fakultas Kedokteran Universitas Islam Bandung

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Abstract

Abstract The development of textile industry in Indonesia can potentially increase some occupational diseases that caused by waste products. One of those waste products from textile industry is cotton dust, which can cause byssinosis. There are several ways to reduce cotton dust exposure, such as using face mask. This research aim to describe the relationship between employees knowledge  about byssinosis with face mask utilization in spinning department of a textile factory.This research is a descriptive study with cross sectional approach. The subjects of this research are employees working on Spinning Department. Data gathered using questionnaire about byssinosis and the habit of using face mask.The result of this research shows that 52 (78.79%) of 66 respondents have excellent knowledge about byssinosis, meanwhile the other 14 (21.21%) show just enough knowledge. Almost all wear a face mask during working hour (92.42%). The result of chi square method shows that the relation between employees knowledge about byssinosis and face mask utilization is really weak (p=0,001, contingency coefficient = 0,381). The result of this research indicates that besides knowledge of byssinosis, there are other factors that can affect face mask utilization. Key word: Byssinosis, knowledge, face-masks

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