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jip@uin-malang.ac.id
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Journal of Islamic Pharmacy
ISSN : 24605182     EISSN : 25276123     DOI : http://dx.doi.org/10.18860/jip
Core Subject : Health, Science,
Welcome to Journal of Islamic Pharmacy (e-ISSN : 2527-6123) formerly Jurnal Farmasains (p-ISSN : 2460-5182) Department of Pharmacy, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Indonesia. The journal was established in 2015 and online publication was begun in 2016. Since 2016, the journal has been published in English and only receives manuscripts in English.
Articles 42 Documents
DESCRIPTION OF KNOWLEDGE AND ATTITUDE OF PROSPECTIVE HAJJ PILGRIMS KBIH MANDIRI 2019 IN MALANG CITY ABOUT HYPERTENSION riskiyah, riskiyah
Journal of Islamic Pharmacy Vol 4, No 2 (2019): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v4i2.8083

Abstract

ABSTRACTHypertension is one of the diseases that can cause people?s death and it usually does not give any symptoms. Hypertension often occurs to the pilgrims. Knowledge and proper attitudes about hypertension of prospective pilgrims from Indonesia, especially in Malang city (East Java), are expected to reduce morbidity and mortality rates because they can manage their illness, properly. The purpose of this study is to describe the level of hypertension-related knowledge and attitudes of prospective pilgrims from KBHI 2019. The method used in this study is a descriptive cross-sectional study. 48 participants have participated in this study. They are the 2019 pilgrims from Indonesia. The results showed that 18 people (38%) had good knowledge about hypertension, 17 people (35%) are intermediately educated and 13 people (27 %) are lack of knowledge. Furthermore, this study has indicated that 25 people (52%) have positive attitudes and 23 people (48%) have negative attitudes about hypertension. This study concluded that in the majority, the 2019 prospective pilgrims from Malang have good knowledge and acceptable attitudes about hypertension.Keywords: Hajj pilgrims, hypertension, knowledge, attitude 
ANALISIS KRITERIA SISTEM JAMINAN HALAL PADA PRODUKSI SUSU DI PT. GREENFIELDS INDONESIA TAHUN 2019 Hartina, Siti; Syahrir, Achmad; Atmaja, Ria Ramadhani Dwi
Journal of Islamic Pharmacy Vol 4, No 2 (2019): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v4i2.8087

Abstract

World demand for halal pharmaceutical products, which include food, cosmetics, drugs, and other products will continue to grow with the increasing of global Moslems population in the world. Milk is one of the pharmaceutical products produced from livestock commodities. It is processed into 2 types of products namely ESL and UHT milk. In Indonesia, the halal status of a product is a crucial point for consumers who are predominantly by Moslems. In its processing, Indonesian Ulema Council (MUI) has a rule called HAS 23101, a halal certification requirement as an implementation of Halal Guarantee System. This study examines the importance of the Halal Assurance System criteria in milk production in the Indonesian food industry. The purpose of this study is to analyse the suitability of the halal guarantee system criteria for milk production in PT. Greenfields Indonesia based on HAS 23101 standards. This research is a descriptive observational study. The data collection process is carried out by providing a checklist to the halal management team in the food industry. The results obtained are the percentage of conformity to the 100% Halal Policy, 100% Halal Management Team, 100% Training and Education, 100% Material, 100% Product, 91.6% Product Facility, Written Procedure for Critical Activity 100%, 100% Search Capability, Products that do not meet 77.8% criteria, 100% internal audit, and 100% management review. The percentage of conformity results obtained as a whole was 97.2%.
PENGARUH VARIASI KONSENTRASI PROPILEN GLIKOL SEBAGAI ENHANCER TERHADAP SEDIAAN TRANSDERMAL PATCH IBUPROFEN IN VITRO Misnamayanti, Misnamayanti; Sugihantoro, Hajar; Fauziyah, Begum
Journal of Islamic Pharmacy Vol 4, No 2 (2019): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v4i2.8029

Abstract

Ibuprofen is an anti-inflammatory class of non-steroidal propionic acid used in the treatment of osteoarthritis, analgesics, and antipyretics. Ibuprofen made in a transdermal patch to avoid side effects of irritation to the stomach, first pass effect on application oral. This aims of the research to determine the physical characteristics of the patch, the effect of propylene glycol concentration (150 mg, 200 mg, 250 mg) on the thickness patch, pH, and the rate of penetration as increase in penetration of the ibuprofen transdermal patch. Patch preparations were made in 3 draft formulas with varying concentrations of propylene glycol 150 mg, 200 mg, and 250 mg. The method used for penetration testing is Franz diffusion cells. The results of physical characteristics are clear, odorless, dry, not cracked,> 300 folds, thickness ranges from 0.142 to 0.184. The concentration of propylene glycol effects (p-value> 0.05) the penetration and no effect (p-value> 0.05) the pH test. Increasing the concentration of propylene glycol causes an increase medicine that penetrate the skin.Keywords: Ibuprofen, transdermal patch, propylene glycol
TRICYCLIC ANTIDEPRESSANTS IN CHRONIC LOW BACK PAIN : A REVIEW Ilmanita, Dzikrina; Hidayati, Hanik Badriyah
Journal of Islamic Pharmacy Vol 4, No 2 (2019): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v4i2.8217

Abstract

Chronic low back pain (LBP) is the frequent chronic pain and notable health problem which is the main reason of disabling conditions, individual suffering, sick leave, and costly treatment.  Unfortunately, available therapy especially oral medicines only beneficial in no more than 50% of patients. Tricyclic antidepressants (TCAs) are commonly used for neuropathic pain but the data for neuropathic LBP is limited. The purpose of this review is to evaluate the efficacy and adverse drug reaction of TCAs in chronic LBP. We searched scientific search engines including Scopus and PubMed and collected original articles including Randomized Clinical Trial (RCT), comparative, and observational study about Tricyclic Antidepressants treatment in chronic LBP from 1998 to 2019. In this review, 5 articles and 543 patients were evaluated. All recruited articles are randomized clinical trials. Among all five relevant articles, three of them evaluate amitriptyline treatment in chronic LBP while the rest articles evaluate imipramine and nortriptyline. Amitriptyline is the most well-studied TCA for chronic LBP. We found that both amitriptyline and nortriptyline can reduce pain severity significantly when the dose is increased gradually depending on patient tolerance. TCAs can also improve disability significantly. However, single-dose imipramine is not superior than placebo. We conclude that TCAs can be effective for treating chronic LBP when used routinely for several weeks and the dose should be increased gradually depending on patient tolerance although further studies are required to confirm the optimal dose for analgesia. The most prevalence Adverse Drug Reactions (ADRs) of TCA including dry mouth, somnolence, insomnia, sedation, and constipation.
THE ROLE OF SUBSTANCE P IN CHRONIC LOW BACK PAIN (CLBP) Rachmawati, Yusnita
Journal of Islamic Pharmacy Vol 4, No 2 (2019): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v4i2.8163

Abstract

Low Back Pain is one of the disease that causing global disability in the worldwide. In the past 10 years, prevalence of LBP has not decreased, it makes global burden increase substantially. Chronic low back pain(CLBP) is pain that is almost experienced daily by patients in the lower back region in a period of more than 3 months. Chronic low back pain is a mixture of pain that arises through nociceptive and neuropathic mechanisms. Over the past decade, numerous  guidelines have been used  in the management of CLBP. Problems that are still a controversy include the management of pain. The mechanism of many treatment measures is still in the low to moderate effectiveness stage, so that the pain management target is not optimal. Substance P is a neuropeptide that release  both in acute and chronic pain. Therefore study about mechanisms that affect SP release may show important information regarding pathological alterations in pain perception.
THE EFFECT OF GINGER RHIZOMES (Curcuma xanthorriza Roxb.) TOWARDS THE NUMBER OF OVARIAN FOLLICLES OF FEMALE MICE (Mus musculus) EXPOSED TO MONOSODIUM GLUTAMAT (MSG) Dianti, Meilina Ratna
Journal of Islamic Pharmacy Vol 2, No 1 (2017): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v2i1.4245

Abstract

Monosodium Glutamat activates an axis ablation in arcuate nucleus hypothalamus which happens to possibly initiate malfunctions in Hipothalamic Pituitary Adrenal axis. Yet, it is known that hypothalamus produces Gonadotropin Releasing Hormone which is able to stimulate the secretion of Gonadotropin Follicle Stimulating Hormon and Luteinizing Hormone from the anterior pituitary gland. These two hormones, however, are essentials for the development of gonad and during the cycles of oogenesis. Hence, any malfunctions resided in the human’s hypothalamus can possibly put endocrine gland into troubles, such as reproduction hormones which affect the workings of gonad. Therefore, the extract of Temulawak is promoted to be the attempt to resolve the issue for its antioxidant properties. Temulawak extract contains antioxidant, properties for as much as 87.01 ppm, according to Rosidi research’s result, analyzing the Temulawak’s potentials. The amount of antioxidant found Temulawak extract is categorized as active and applicable as natural antioxidant source. However, this research adopts true experimental post-test only control group design. It includes 5 (five) groups of female mice as which are K1 (CMC), K2 (CMC+MSG), P1 (MSG+0.4 mg Temulawak extract), P2 (MSG+0.8 MG Temulawak extract), P3 (MSG+1.2 mg Temulawak extract). In addition, the mice’s ovaries are removed to be subsequently tested using Hematoxillin-Eosin and the ovaries’ follicles quantity is observed and counted. The data is analyzed using One Way ANOVA. The research finally comes with a result showing that there are not any significant differences discovered from the ovaries’ follicles quantity from the five tested groups (p>0.05). Therefore, it is implied that Temulawak extract does not provide any influential results to the house mice’s ovaries’ follicles quantity which has been exposed to MSG. Keywords: Monosodium Glutamate (MSG), Temulawak (Curcuma xanthorriza Roxb.), Ovarian follicles quantity 
Combination of Calotropis gigantea Radix Extract and Artemisin as an Antimalarial Agent Against Plasmodium berghei Muti’ah, Roihatul; Hayati, Elok Kamilah; Fatati, Asnal
Journal of Islamic Pharmacy Vol 1, No 1 (2016): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v1i1.3456

Abstract

Calotropis gigantea radix is one of plant which has bioactive component as antimalarial.The purpose of this research are to know antimalarial activity from combination of Calotropis gigantea radix extract and artemisin. The research consist of extraction of Calotropis gigantea radix was done with extraction maseration method. Extraction was performed by maseration with  80% ethanol solvent. Concentrated extract was in vivo antimalarial tested to animal model. Mice were peritoneal infected with 106Plasmodium berghei ANKA and divided into 5 treatment groups: negative control; positive control (artemisin of dose 4 mg/kgBW); combination of artemisin(1/4 dose of artemisin standar) and Calotropis giganteain 3 doses: 0,1 mg/KgBW; 1 mg/KgBWand 10 mg/KgBW. Data of inhibition was analyzed using SPSS program with Two Way ANOVA Test dan continued with Tukey Test.The result shows that combination of Calotropis gigantea radix extract and artemisin with dose 10 mg/KgBB has higher antimalarial activity than control positive (artemisin). The value of parasite inhibition is 55,2% for dose 0.1 mg/KgBW ; 72,8% for dose 1 mg/KgBW ; 87,3% for dose 10 mg/KgBW and 56,06 mg/KgBW for control positive (artemisin). The phytochemical compounds in 80%  ethanol solvent extract are tannins and steroids. Keywords: Calotropis gigantea,antimalaria, combination, artemisin, Plasmodium berghei
Profile Number of Mice Takizoit after Treatment With Alkaloid Fraction of Alstonia scholaris Leaves Hakim, Abdul
Journal of Islamic Pharmacy Vol 1, No 1 (2016): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v1i1.3455

Abstract

The prevalence of toxoplasmosis in Indonesia at 2006 was 43-88%. Drugs that have been the most widely used for the treatment of patients with toxoplasmosis include pyrimethamine and spiramicin. However, these drugs have been reported to cause side effects such as bone marrow suppression, penetrate the blood brain barrier, crossed the placenta and fetal blood. Therefore necessary to find alternative drugs for toxoplasmosis effective and safe. This research studied the effect of alkaloid fraction of leaves of plants Alstonia scholaris to the number takizoit profiles in intraperitoneal fluid of mice infected with Toxoplasma gondii. This research used the experimental animals were grouped as the control group and the treatment group. In the treatment group, each group was given treatment with fraction extract alkaloids from leaves of plants Pulai. The results showed the number takizoit mice infected with Toxoplasma gondii parasites without therapy is 957.5 x 103 whereas the alkaloid fraction of the ethanol extract of leaves is 737.5 x 103. Keywords: Leaves of Pulai (Alstonia scholaris), Toxoplasma gondii, toxoplasmosis.
Identification of Active Compounds Calotropis gigantea Stem Extracts as Antimalarials Agents on Animal Infected Plasmodium berghei Shofiyullah, Muhammad; Hayati, Elok Kamilah; Indradmojo, Chrystiaji
Journal of Islamic Pharmacy Vol 1, No 1 (2016): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v1i1.3454

Abstract

Thistle (Calotropisgigantea) is a wild plant that contains secondary metabolites as a potential antimalarial drugs.This study aims to determine the content of active compound contained, the potential of ethanol extract of the stem thistle as an antimalarial, and knowing the best eluent used when TLC test.This study covers the extraction of stem thistle using maceration for 24 hours using ethanol 80%.Stirring assisted with shaker for 3 hours. Ekstrak concentrated phytochemical test, antimalarial activity was evaluated by experimental animals mice infected by Plasmodium berghei.Data degree of parasitaemia in mice were analyzed using Minitab 16 with Test TwoWay ANOVA followed by Tukey test.The results showed that ethanol extract stem thistle contains the active compound class of triterpenoids, and potentially as an antimalarial with ED50 values 152.878 mg / kg bw were included in both categories.TLC test results showed that the best eluent for the separation of triterpenoids of stem thistle extract is benzene: chloroform (3: 7) which produced 12 spots with Rf values of 0.04;0.06;0.14;0.21;0.29;0.35;0.41;0.48;0.80;0.84;0.88;0.91. Keywords: Antimalarial, Calotropisgigantea, Ethanol 80%, Plasmodium berghei, Thin Layer Chromatography
The Effect of Carica Pubescens Lenne and K. Koch Fruit Extract from Dieng Plateau and Cangar to the Amount of Fibroblasts Cells on the Healing of Oral Mucosal Inflammation Kristanti, Risma Aprinda
Journal of Islamic Pharmacy Vol 1, No 1 (2016): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v1i1.3457

Abstract

The purposes of this research are to know the effect of C.pubescens fruit extract on the amount of gingival fibroblasts in wound healing of Rattus norvegicus mouth cavity’s mucosal and to know the effect of C.pubescens comes from two different areas (Dieng and Cangar) on the amount of gingival fibroblasts in wound healing of Rattus norvegicus oral mucosa. Twenty eight rats are divided to be four groups (K1, K2, K3, and K4), each rat is wounded 1 cm on the gingival mucosa of lower jaw (specifically on the apical region of incisive teeth). K1 is the control group with aquadest treatment on the wound. The wound in the K2 is treated with C.pubescens fruit extract from Dieng. The wound in the K3 is treated with C.pubescens fruit extract from Cangar. And the treatment for K4 is medicated by policresulen (common medicine for oral mucosal wound). On the fifth day of the treatment, all rats are sacrificed, and the gingival tissue is taken up for the next step. Gingival tissue is smeared by Haematoxylin Eosin (HE) to analyze the amount of gingival fibroblasts histologically. The result of this research shows that the highest average amount of gingival fibroblasts comes from K4 (policresulen treatment). And there is no significant difference on the number of Rattus norvegicus gingival fibroblasts from all of the groups (K1, K2, K3, and K4). Keywords: fibroblast, gingival, wound, mucosa, mouth, C.pubescens