Triastuti, Felicia Melani
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ASSOCIATION OF E-CADHERIN EXPRESSION TO CLINICAL STAGE OF NASOPHARYNGEAL CARCINOMA Triastuti, Felicia Melani; Asnir, Rizalina A. ; Yudhistira, Ashri ; Eliandy, Sutoyo
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA (IJNPC) Vol 1 No 01 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (724.374 KB) | DOI: 10.32734/ijnpc.v1i1.953

Abstract

Background: Nasopharyngeal carcinoma (NPC) has a high incidence rate in southern China and Southeast Asia and a high rate of metastasis in head and neck cancer. NPC is a squamous cell carcinoma that grows from the surface of the lateral wall of the nasopharynx. E-cadherin is known as a tumor suppressor protein and the loss of this expression in tumor cells is related to epithelial-mesenchymal transition that occurs during tumor development and metastasis. Objective:To determine the relationship between E-cadherin expression and clinical stage in patients with nasopharyngeal carcinoma. Methods: An analytical study with a cross-sectional study design, the number of samples was 30 patients with NPC who underwent immunohistochemical examination on KNF paraffin block. Result: Overexpression of E-cadherin was found in T1 and T2 of 15 subjects (100%). The overexpression of E-cadherin was found in lymph node N2 and N3 of 19 subjects (95%). The overexpression of E-cadherin was found in the histopathological type of Non-Keratinizing Squamous Cell Carcinoma of 24 subjects (96%). The overexpression of E-cadherin was found at an advanced stage of 26 subjects (100%). Conclusion: No significant association was found between E-cadherin expression and tumor size (p = 1,000), lymph node metastasis (p = 1,000), histopathological type (p = 1,000) and tumor stage (p = 0.133).