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Gambaran Hasil Pemeriksaan Monofilamen pada Pasien Diabetes Melitus (DM) yang Berkunjung ke Poliklinik Penyakit Dalam RSUD Arifin Achmad Provinsi Riau Safitri, Viona Ayu; Rosdiana, Dani; Astari, Riezky Valentina
Jurnal Ilmu Kedokteran Vol 11, No 2 (2017): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (95.251 KB) | DOI: 10.26891/JIK.v11i2.2017.34-39

Abstract

Diabetes mellitus in increasing at an alarming rate and has become a global challenge. Diabetes mellitus type 2 is agroup of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin actionor both. One of the most complications of diabetes is diabetic neuropathy. Diabetic neuropathy refers to damage ofmotor nerves, sensory, and autonomic system. The aim of this study is to identify patients at risk for diabetic neuropathywith monofilament examination in internist polyclinic Arifin Achmad General Hospital from May to July 2017.Monofilament is an inexpensive, practical tool in everyday use and can be used in early detection of sensation loss inthe foot to prevent diabetic ulcer. This study is descriptive research with direct examination of patient diabetes type 2.There were 73 samples that fulfilled the inclusion criteria. Profile patients with diabetes in the polyclinic are female morethan male is 60,3%. The age group 56-65 years is the most age group of DM patients in the polyclinic is 52.1%.Duration of diabetes is 5-10 years (52.1%). The results of monofilament examination in patients with type 2 DM arescore 0-3 as many as 19 people (26%), score of 3.5-5 as many as 27 people (37%), and score> 5,5 as many as 27 people(37%).
Stres Imobilisasi Kronik Mengganggu Memori Spasial Mencit Putih (Mus musculus) Galur Swiss Webster Jantan Juananda, Desby; Astari, Riezky Valentina
ANATOMICA MEDICAL JOURNAL | AMJ Vol 1, No 1 (2018): Anatomica Medical Journal
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (325.885 KB)

Abstract

Long-term exposure to stress may induce structural and functional alterations in the brain and particularly in hippocampus. Several studies have shown that the hippocampus plays an important role in spatial learning and memory. Certain animals can perceive stressors differently depend on stress durations and paradigms. We have designed an investigation to compare the effect of different chronic stress durations, using immobilization tubes, on mice spatial memory ability. Twenty young-adult (10-12 weeks old; 25-35 g) male Swiss Webster mice were randomly assigned into four groups: control (non-stressed) group and groups were exposed to immobilization stress 2 hours/daily (09.00-11.00 am) for 14, 21 and 28 days, respectively. Spatial memory ability was tested by using Morris Water Maze. Data were analyzed with one-way ANOVA (p<0.05). We found that mean escape latency (s) for control, 2h/14 days, 2h/21 days and 2h/28 days groups were 8.49 ± 0.91, 12.40 ± 3.76, 13.73 ± 4.09, and 41.62 ± 21.84, respectively (p<0.05). Post-hoc analysis showed a statistical difference between control and stressed groups (p<0.05), but there was no statistical difference between 2h/21 days and 2h/14 days group (p>0.05). In conclusion, this study showed that chronic immobilization stress had been proven to impair spatial memory ability in mice. Specifically, our findings support the use of 2h/28 days chronic immobilization paradigm as an efficient method to induce spatial memory deficits in mice. Keywords: immobilization stress, Morris Water Maze, spatial memory
HUBUNGAN NILAI NATRIUM SERUM DENGAN LUARAN FUNGSIONAL PADA PASIEN CEDERA KEPALA Riezky Valentina Astari,* Jimmy Eko Budi Hartono,** Dody Priambada***
NEURONA Vol 33 No 1 Desember 2015
Publisher : Neurona Majalah Kedokteran Neuro Sains

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Abstract

INTRODUCTION SODIUM LEVEL DISTURBANCE IS COMMON AFTER TRAUMATIC BRAIN INJURY AND MAY CAUSE SERIOUS COMPLICATIONS AND POOR OUTCOME INCLUDING DEATH SODIUM PLAY A ROLE IN CYTOTOXIC PROCESS AND REPERFUSION PATHWAY IN SECONDARY BRAIN DAMAGE SERUM SODIUM LEVEL AND ITS RELATIONSHIP WITH OUTCOME IN BRAIN INJURY IS SCARCELY STUDIED
PERBANDINGAN PROFIL GLUKOSA DARAH PASIEN STROKE ISKEMIK DAN STROKE HEMORAGIK DI RSUP FATMAWATI TAHUN 2018 Husna, Intan Rahma; Astari, Riezky Valentina; Rizkianti, Tuty
Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan Vol 5, No 1 (2021): Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan
Publisher : Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jmstkik.v5i1.8217

Abstract

Stroke is the death of brain cells due to lack of blood flow and oxygen to the brain by blockage or rupture of an artery. Stress hyperglycemia in acute stroke may worsen the clinical outcome and the prognosis of stroke. The purpose of this study is to find out and compare blood glucose profile between ischemic stroke and hemorrhagic stroke. This is an observational analytic cross-sectional research using consecutive sampling. Data was obtained through medical record from January to December 2018 in RSUP Fatmawati with each group of stroke consisting of 74 samples. Data was processed using SPSS 2017. Mann-Whitney test shows a significant difference in random blood glucose levels between ischemic stroke and hemorrhagic stroke (p = 0.024), with the median value of random blood glucose level during ischemic stroke is 115.50 mg / dL and hemorrhagic stroke is 136.50 mg / dL. The results also shows a significant difference in fasting blood glucose levels between ischemic stroke and hemorrhagic stroke (p = 0.042), with the median value of fasting blood glucose level for ischemic stroke is 116.50 mg / dL and hemorrhagic stroke is 125.50 mg / dL. A significant difference is also seen in 2 hours post-prandial glucose level between ischemic stroke and hemorrhagic stroke (p = 0.028), with the median value of 2 hours post-prandial glucose level of  ischemic stroke is 130 mg / dL and hemorrhagic stroke is 147.50 mg / dL. Keywords: Ischemic Stroke; Hemorrhagic Stroke; Random Blood Glucose; Fasting Blood Glucose; 2 Hour Post-Prandial Blood Glucose AbstrakStroke adalah kematian sel-sel otak akibat hilangnya pasokan darah dan oksigen ke otak karena adanya  hambatan atau ruptur arteri yang menuju otak. Pada stroke fase akut dapat terjadi hiperglikemia reaktif yang dapat memperburuk  keluaran klinis dan prognosis stroke. Penelitian ini dilakukan untuk mengetahui dan membandingkan profil glukosa darah antara stroke iskemik dan stroke hemoragik. Penelitian ini bersifat analitik observasional dengan desain potong lintang dan pemilihan sampel consecutive sampling. Data didapat dari rekam medis periode Januari-Desember 2018 di RSUP Fatmawati dengan masing-masing kelompok stroke sebanyak 74 sampel. Pengolahan data dilakukan dengan program SPSS tahun 2017. Uji Mann-Whitney menunjukkan adanya perbedaan bermakna kadar Glukosa Darah Sewaktu antara stroke iskemik dengan stroke hemoragik (p = 0,024), dengan nilai median Glukosa Darah Sewaktu stroke iskemik adalah 115,50 mg/dL dan stroke hemoragik adalah 136,50 mg/dL. Hasil juga menunjukkan adanya perbedaan bermakna kadar Glukosa Darah Puasa antara stroke iskemik dan stroke hemoragik (p = 0,042), dengan nilai median Glukosa Darah Puasa stroke iskemik adalah 116,50 mg/dL dan stroke hemoragik adalah 125,50 mg/dL, serta adanya perbedaan bermakna kadar Glukosa Darah 2 Jam Post-Prandial antara stroke iskemik dan stroke hemoragik (p = 0,028), dengan nilai median Glukosa Darah 2 Jam Post-Prandial stroke iskemik adalah 130 mg/dL dan stroke hemoragik adalah 147,50 mg/dL.
The Effect of Antinociceptive Flavonoid on Leea Indica Leaves for Orofacial Pain of Adult Zebra Fish (Danio Rerio) Daya, Mei Putra; Saleh, Arman Yurisaldi; Astari, Riezky Valentina
Folia Medica Indonesiana Vol 57, No 2 (2021): June
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v57i2.17711

Abstract

Pain affects millions of people and is one of the most frequent complaints in the medical office. Pain involves various behavioral and emotional aspects. When it is persistent, it can become debilitating, impairing occupational performance, and producing negative impacts for the economy and public health costs. In general, commercial drugs can improve chronic pain patients' quality of life which can result in adverse reactions. Therefore, the search for new capsules as an opportunity remedy for ache is a challenge. Pain occurs due to stimuli from pain receptors called nociceptors. One pain known in the medical world is orofacial, defined as pain that occurs in soft and hard tissue in the head, face, and neck area. This study determined the antinociceptive effect of flavonoids isolated from the Leea Indica plant, on orofacial pain in zebrafish (Danio rerio) as a test model for behavior or locomotor activity. To study the orofacial pain of zebrafish induced with glutamate, this study was a true experiment. The parameter used was the number of times the fish crossed the line between the caudran from the glass petri dish during 0-5 minutes and 15-30 minutes. The Anova one-way test showed that there were differences in locomotors activity measured from 0-5 minutes and 15-30 minutes by giving flavonoids that could affect zebrafish locomotors activity or an increase in zebrafish locomotors activity. The antinociceptive effect of flavonoids was similar to tramadol. The flavonoids from Leea Indica had an antinociceptive effect on orofacial pain in adult zebrafish. The flavonoid dose of 2.5 mg/ml was a dose that had a significant difference in all treatment groups.