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Uji Aktivitas Antioksidan Ekstrak Etanol Fraksi Heksan, Fraksi Etil Asetat dan Fraksi Air Daun Kapulaga (Elettaria cardamomum (L.) Maton) ASRA, RIDHO; Azni, Nize Ria; Rusdi, Rusdi; Nessa, Nessa
Journal of Pharmaceutical And Sciences Vol 2 No 1 (2019): JPS Volume 2 Nomor 1 (2019)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v2i1.17

Abstract

This study aims to determine the antioxidant activity of the ethanol extract, hexane fraction, ethyl acetate fraction and water fraction of cardamom leaves (Elettaria cardamomum (L.) Maton). Dried of cardamom leaves was extracted by maceration using 70 % ethanol, then followed by fractionation based on the level of polarity with hexane, ethyl acetate, and water solvents. Antioxidant activity examination was determined using reagent DPPH using UV-Visible spectrophotometry and gallic acid as standard. The results of phytochemical screening showed that ethanol extract and water fraction of cardamom leaves contains phenol, flavonoids, tannins, and saponins, for ethyl acetate fraction contains phenol, flavonoids, and tannins, for hexane fraction the results were negative for all the compounds tested. The results of the antioxidant activity examination of ethanolic extract, hexane fraction, ethyl acetate fraction and water fraction of cardamom leaves showed the IC50 of 4058.7 μg/mL, 8419.3 μg/mL, 2281.7 μg/mL, and 3889.6 μg/mL respectively, whereas gallic acid showed the IC50 value of 4.89 μg/mL. Based on IC50 values ethanol extract, hexane fraction, ethyl acetate fraction and water fraction of cardamom leaves have weak antioxidant activity compared to gallic acid which has high antioxidant activity.
Analisis Ketepatan Pemilihan dan Penentuan Regimen Obat pada Pasien Penyakit Paru Obstruktif Kronis (PPOK) R, Zulkarni; Nessa, Nessa; Athifah, Yumna
Jurnal Sains Farmasi & Klinis Vol 6, No 2 (2019): J Sains Farm Klin 6(2), Agustus 2019
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (497.432 KB) | DOI: 10.25077/jsfk.6.2.158-163.2019

Abstract

Penyakit paru obstruktif kronik (PPOK) adalah penyakit kronis paru-paru dengan karakteristik resistensi aliran udara yang benar-benar tidak dapat dipulihkan atau pulih sebagian dan progresif. Organisasi Kesehatan Dunia (WHO) telah memperkirakan bahwa jumlah kasus COPD akan meningkat dari peringkat 6 pada tahun 1990 menjadi peringkat 3 pada tahun 2020 sebagai penyebab kematian paling umum di dunia, termasuk di Indonesia. Pentingnya menginformasikan keakuratan pemilihan obat dan penentuan regimen adalah untuk meningkatkan rasionalitas obat-obatan. Penelitian ini bertujuan untuk memperoleh gambaran ketepatan pemilihan obat dan penentuan regimen PPOK pada pasien dengan rawat inap COPD Mayor Jenderal H.A Thalib Kab.Kerinci. Jenis penelitian adalah deskriptif, pengambilan data dilakukan secara prospektif melalui rekam medis pasien untuk periode Maret-Mei 2018 dan dengan teknik pengumpulan data dalam bentuk total sampling. Sampel yang sesuai dengan kriteria inklusi penelitian diperoleh 30 sampel. Pada hasil penyajian data deskriptif, penilaian akurat berdasarkan pemberian obat COPD pada pasien ada pemilihan obat yang tepat yaitu 74,83%, penentuan regimen obat 100% dan evaluasi pemantauan pasien yang diobati COPD sembuh 100%
PENETAPAN KADAR LOGAM KALSIUM DAN BESI PADA DAUN KELOR (Moringa oleifera Lam) DENGAN SPEKTROFOTOMETER SERAPAN ATOM Asra, Ridho; Harefa, Festires Kurnia; Zulharmita, Zulharmita; Nessa, Nessa
Journal of Pharmaceutical And Sciences Vol 1 No 1 (2018): JPS Volume 1 Nomor 1 (2018)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v1i1.5

Abstract

The determination of calcium and iron metal in moringa leaf sample obtained from Purus area, Padang Barat has been done. In this study, the destruction method that has been used was wet destruction, the result of this method was determined with atomic absorption spectrophotometer by using Ca and Fe hallow cathode lamp. Based on the result of this study, a linear regression equation of calcium standard solution which was y = 0,03818 + 0,17036x, with r = 0,9997 and a linear regression equation of iron standard solution which was y = 0,03831 + 0,064275x, with r = 0,9986. The limit of detection (LOD) and the limit of quantitation (LOQ) of calcium was 0,0678 mg/kg and 0,2261 mg/kg and then the limit of detection (LOD) and the limit of quantitation (LOQ) of iron was 0,5790 mg/kg and 1,9292 mg/kg. The results of the determination of calcium content in moringa leaf with three replications were 1277,986 mg/kg, 1269,178 mg/kg, 1229,063 mg/kg so that the average calcium content in the moringa leaf was 1258,742 mg/kg. The results of the determination of iron content in moringa leaf with three replications were 210,509 mg/kg, 198,985 mg/kg, 206,117 mg/kg so that the average iron content in moringa leaf was 205,204 mg/kg.
Studi Fisikokimia Betasianin Dalam Kulit Buah Naga dan Aplikasinya Sebagai Pewarna Merah Alami Sediaan Farmasi: Physicochemical Study of Betacyanin from Dragon Fruit Rind and Its Application as Natural Dye for Pharmaceutical Dosage Form Asra, Ridho; Yetti, Rina Desni; Rusdi, Rusdi; Audina, Selly; Nessa, Nessa
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.638 KB) | DOI: 10.22487/j24428744.2019.v5.i2.13498

Abstract

The rind of dragon fruit (Hylocereus lemairel (Hook.) Britton & Rose) is a waste material that has not been optimally utilized. The rind contains betacyanin pigment that has many benefits in pharmaceutical products. The study aimed to characterize the physicochemical properties, to evaluate the stability and to apply betacyanin in dragon fruit rind as a natural dye. The extraction process was done by using water as solvent which was sonicated at 50 kHz for 30 minutes at 25 °C. Extract was freeze dried for 48 hours. The dried extract was purified by using preparative TLC and physicochemically analyzed by using UV-Vis and FTIR spectrophotometer. The stability of betacyanin extract against pH and temperature was examined and applied as a dye in tablet imprinting. The result of this study indicated that betacyanin was found at Rf value of 0.6 same as the betacyanin standard. The maximum wavelength of betacyanin was obtained at 534 nm and the IR spectra showed similarity with betacyanin standard with the same functional groups between 4000-600 cm-1 although there was a slight shift in the wavenumber but it still in the range. The stability study were stable at temperature below 40 °C and at range pH 4-6. Betacyanin applications as natural dye of tablet have been successfully carried out with good color stability during 3 months of storage at room temperature.
STUDI FISIKOKIMIA EKSTRAK UMBI BIT MERAH (BETA VULGARIS L) SEBAGAI PEWARNA PADA SEDIAAN TABLET Asra, Ridho; Azizah, Zikra; Yetti, Rina Desni; Ratnasari, Desi; Chandra, Boy; Misfadhila, Sestry; Nessa, Nessa
Jurnal Farmasi Higea Vol 12, No 1 (2020)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (878.124 KB)

Abstract

Umbi bit merah (Beta vulgaris L.) mengandung pigmen betasianin yang berfungsi sebagai alternatif pewarna alami. Pada penelitian ini betasianin dari ekstrak umbi bit merah di ekstraksi dengan metode ultrasonic assisted extraction (UAE) menguunakan pelarut air dan dikeringkan dengan metode Frizee Draying. pengujian betasianin dari sekstrak umbi bit merah dilakukan dengan kromatografi lapis tipis diperoleh nilai Rf = 0,7 dan panjang gelombang maksimum 535 nm yang di analisis dengan metode spektrofotometri UV-Vis. Spektrum FTIR  menunjukan bahwa pada isolat terdapat adanya gugus fungsi yang identik dengan betasianin standar. Betasianin dalam ekstrak diperoleh dengan kadar 98,6474% yang stabil pada suhu 40 °C dan pH 5. Zat warna betasianin dari ekstrak umbi bit merah telah diaplikasikan dalam sediaan farmasi, dan pada penelitian ini zat warna betasianin dari ekstrak dapat digunakan sebagai pewarna alami untuk sediaan tablet.
STUDI FISIKOKIMIA BETASIANIN DAN AKTIVITAS ANTIOKSIDAN DARI UMBI BIT MERAH (Beta vulgaris L.) ASRA, RIDHO; Yetti, Rina Desni; Ratnasari, Desi; Nessa, Nessa
Journal of Pharmaceutical And Sciences Vol 3 No 1 (2020): JPS Volume 3 Nomor 1 (2020)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v3i1.35

Abstract

Red beet tubers (Beta vulgaris L.) contain 5-O-beta-glycoside betacyanin compounds which have many benefits. One of which is an antioxidant. Activity study, have been done antioxidant acting test from red beet tubers (Beta vulgaris L.) was extracted using the Ultrasonic Assisted Extraction (UAE) method using a water solvent and dried by freeze-drying method for 48 hours. Betacyanin was identified by thin-layer chromatography with Rf value 0.7166 and a wavelength of 535 nm analyzed by UV-Vis spectrophotometry. The FTIR spectrum shows that isolates contain functional groups that ware similar to betacyanin standard (Sigma Aldrich). Betasianin obtained in red beetroot extract with levels of 98.6474%. The red beetroot is stable at 40 °C and pH 5. Test its antioxidant activity using the DPPH method (1,1-diphenyl-2-picrylylhydrazyl) with a wavelength of 515.50 nm. The results of this study indicate the antioxidant activity from of red beet tubers (Beta vulgaris L.) with IC50 values of 21.8878 µg/mL, compared to IC50 values of vitamin C 7.1099 µg/mL. it can be concluded that the red beet tubers have a potent antioxidant activity (high antioxidant <50 µg / mL).