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IMMUNOPROTECTIVE EFFECT OF MELATONIN ADMINISTRATION ON METHYLPREDNISOLONE-TREATED WISTAR MALE RAT (RATTUS NORVEGICUS) Manus, Widya Christine; Pangkahila, Wimpie; Aman, I Gusti Made
Berkala Ilmiah Kedokteran Duta Wacana Vol 4, No 2 (2019): Berkala Ilmiah Kedokteran Duta Wacana
Publisher : Faculty of Medicine Universitas Kristen Duta Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3423.507 KB) | DOI: 10.21460/bikdw.v4i2.150

Abstract

Background: Immune system function decreases with age. Steroid use might accelerate this process, especially in adults in Indonesia. Melatonin is a natural hormone which show antioxidant effect and immunoprotective effect. Melatonin administration might help in reviving humane immune system due to aging and exogenous steroid exposure. Objective: This experiment is aimed to determine the effect of melatonin on leukocyte and lymphocyte count of methylprednisolone-induced immunosuppression on Wistar rat. Method: This study was true experimental with post-test only control group design using 32 male rats. Rats were divided into control and the intervention group. Control group was given methylprednisolone 0.144 mg/200 g rat 3 times a day and distilled water. The treatment group was given methylprednisolone 0.144/200 g rat 3 times a day and 0.054 mg/200 g melatonin once daily. The blood was taken after 14 days of treatment. Results: Intervention group shows higher lymphocytes count (4.95 ±1.58x103/?L) compared to the control group (3.09?1.33x103/?L), with p < 0.01. The intervention group also has higher leukocyte count (8.37± 2.02x103/?L) compared to the control group (6.70 ± 1.96x103/?L), with p
The Impact of Bina Keluarga Lansia Program on the Quality of Life of Elderly in Sleman, Yogyakarta Perdamaian, Teguh Kristian; Manus, Widya Christine; Periska, Septian Dewi; Steffiasih, Ni Nengah Petra Ayu
KEMAS: Jurnal Kesehatan Masyarakat Vol 15, No 3 (2020): KEMAS
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v15i3.19104

Abstract

Indonesian government, through BKKBN, has joined to promote healthy life in the elderly in the community. Bina Keluarga Lansia (BKL) programme was established to fulfil elderly need through a family-based approach. This study is aimed to evaluate the programme with the examination of the quality of life of its members, including the elderly and their family member. We used a cross-sectional method using WHO-QOL BREF questionnaire to assess the quality of life and another questionnaire to enlist the involvement on the BKL activities. This study was conducted in 2018, at four BKL groups across Sleman Regency. Further analysis was conducted with gaussian mix models to adjust for the cluster effect from sampling method. Our 103 respondents with 68 family members and 35 elderly generally have a good quality of life on four dimensions of WHO-QOL BREF. We found that BKL activities statistically significant associated with better QoL, especially in Social Domain and Psychological Domain. Activities that were specifically associated with better QoL was health education on elderly resilience and art/music activities. Other activities that show borderline association was business activities. BKL programme has shown an association with better QoL, thus any successful activities should be maintained or improved, and other less influential activities should be reviewed and customised with local needs.
MITOCHONDRIA AND THE FUTURE OF MEDICINE Manus, Widya Christine
Berkala Ilmiah Kedokteran Duta Wacana Vol 4, No 1 (2019): Berkala Ilmiah Kedokteran Duta Wacana
Publisher : Medical Faculty of Duta Wacana Christian University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (928.107 KB) | DOI: 10.21460/bikdw.v4i1.144

Abstract

Mitochondria and the Future of Medicine