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REVIEW ARTICLE: AMEBIASIS MOLECULAR PATHOGENESIS DEVELOPMENT Muliani, Nurlina; Salim, Hotimah Masdan
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 2 (2019): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v3i2.1195

Abstract

Amebiasis is one of the gastrointestinal tract infection disease caused by Entamoeba histolytica ,a parasitic protozoan. Amebiasis is the second disease, caused by parasite, that leading cause of death after malaria. Infection occurs through faecal-oral route and after ingestion a contaminated food and beverages by human faeces. The pathogenesis of E. histolytica can be classified into 3 processes, i.e: death of host cell, inflammation, and parasitic invasion. The recent years, a molecularly amebiasis pathogenesis has been developed, i.e: adherence, phagocytosis, tropogocytosis of host cell and how the parasites can survive and attack host cells so it can cause an infection in humans. Molecular development is an important thing to be considered in the selection of amebiasis therapy.
REVIEW ARTICLE: AMEBIASIS MOLECULAR PATHOGENESIS DEVELOPMENT Muliani, Nurlina; Salim, Hotimah Masdan
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 2 (2019): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v3i2.1195

Abstract

Amebiasis is one of the gastrointestinal tract infection disease caused by Entamoeba histolytica ,a parasitic protozoan. Amebiasis is the second disease, caused by parasite, that leading cause of death after malaria. Infection occurs through faecal-oral route and after ingestion a contaminated food and beverages by human faeces. The pathogenesis of E. histolytica can be classified into 3 processes, i.e: death of host cell, inflammation, and parasitic invasion. The recent years, a molecularly amebiasis pathogenesis has been developed, i.e: adherence, phagocytosis, tropogocytosis of host cell and how the parasites can survive and attack host cells so it can cause an infection in humans. Molecular development is an important thing to be considered in the selection of amebiasis therapy.
Profil Kualitas dan Kuantitas Penggunaan Antibiotik Profilaksis pada Pre, On, dan Pos Bedah di Rumah Sakit Provinsi (RSP) NTB Massey, Firdaus Kabiru; Yulia, Rika; Muliani, Nurlina; Herawati, Fauna
Jurnal Sains Farmasi & Klinis Vol 8, No 1 (2021): J Sains Farm Klin 8(1), April 2021
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.8.1.43-52.2021

Abstract

Penelitian ini bertujuan untuk mengetahui profil kuantitas penggunaan antibiotik berdasarkan metode DDD/100 patient-days dan kualitas penggunaan antibiotik berdasarkan persentase kesesuaian (indikasi, waktu pemberian, durasi, dosis, dan rute pemberian) terhadap ASHP, PPAB, dan Formularium Rumah Sakit, serta profil Infeksi Daerah Operasi (IDO) pada pasien bedah di RSP NTB periode Januari-Juni 2019. Metode penelitian menggunakan desain penelitian deskriptif dengan pengambilan data secara retrospektif terhadap data rekam medik sampel penelitian. Subyek penelitian adalah pasien bedah periode Januari-Juni 2019 yang memenuhi kriteria inklusi, yaitu sebanyak 323 sampel penelitian. Hasil yang diperoleh dari penelitian ini yaitu kuantitas penggunaan antibiotik periode Januari-Juni 2019 di dominasi oleh antibiotik ceftriaxone (J01DD04) dengan nilai total DDD/100 patient-days pada pre operasi yaitu 77,655, on operasi 87,31, dan post operasi 93,65. Kesesuaian pemilihan antibiotik profilaksis berdasarkan guideline ASHP sebesar 1,9%, PPAB 15,5%, dan Formularium RSP NTB 100%, sedangkan kesesuaian durasi, waktu pemberian, dosis, dan rute pemberian berdasarkan ASHP berturut-turut yaitu 19,2%, 42,7%, 1,5%, dan 100%. Sampel penelitian yang mengalami IDO yaitu 2 dari 323 sampel (0,62%) dengan hasil pertumbuhan bakteri yaitu Proteus sp., Staphylococcus aureus, S. epidermidis, dan E.coli. Uji sensitivitas keseluruhan bakteri penyebab IDO ditemukan masih sensitif terhadap antibiotik seperti chloramphenicol, amoxicillin-clavulanic acid, vancomycin, cefoxitin, dan oxacillin