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Effects of AntiMycobacterium Tuberculosis Nanoherbal Legundy Leaf Extract (Vitex trifolia) Dwiyanti, Atika; Mulyani, Siti; Yulhan, Oche Axena; Lubis, Humairah Medina Liza; Roslina, Ance
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 21, No 1: January 2021
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v21i1.6497

Abstract

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Indonesia ranks 2nd largest in the world after India. Resistance to anti-tuberculosis drugs is one of the difficulties in treating tuberculosis. This research aim to determine the effectiveness of legundi (Vitex trifolia) leaf extract nanoherbal in killing Mycobacterium tuberculosis. This study was conducted with an experimental design using M. tuberculosis colonies taken from 25 samples of aspirate of tuberculosis patients with lymph nodes and then given the ethanol extract of legundi leaves (70% and 90%) with the process of making nanoparticle extracts. The evaluation of the observations was in the form of measuring the inhibition zone for bacterial growth which were categorized as weak ( 5mm), moderate (6-10mm), strong (11-20 mm) and very strong ( 21mm). The results of the study from 6 repetitions found that the inhibition zone category was 0% weak, 39% moderate, strong 52.3%, and very strong 8.7%. Comparison of the concentration of legundi leaf extract to the diameter of the bacterial growth inhibitory zone was analyzed using the Kruskal Wallis test, which found a significant relationship with p value = 0.000 ( 0.05). Legundi's leaf extract can be used as an antibacterial agent for M. tuberculosis. 
PENGARUH PEMBERIAN MADU TERHADAP KADAR KOLESTEROL TOTAL DAN TRIGLISERIDA TIKUS PUTIH ( RATTUS NORVEGICUS L.) JANTAN GALUR WISTAR YANG DIINDUKSI TUAK LUBIS, DEA YULIA; ASFUR, ROBITAH; ANDINA, MEIZLY; LUBIS, HUMAIRAH MEDINA LIZA
JURNAL ILMIAH KOHESI Vol 3 No 3 (2019): JURNAL ILMIAH KOHESI
Publisher : LP2MTBM MAKARIOZ

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Abstract

Metabolic syndrome is accumulation of symptoms that induce cardiovascular disease. Cardiovascular disease is the first cause of death and has a high prevalence in the world. According to the study in Finlandia, people with metabolic syndrome will have 3,5 higher risk of cardiovascular disease. In metabolic syndrome the level of triglyceride will increase because of atherogenic diet, less of physical activity, and alcohol consumption. Honey is a sweet liquid that is produced by the bee from nectar and contains antioxidant. Objective : This experiment study the effect of honey for total cholesterol and triglyceride in Wistar male white rat (Rattus norvegicus L) induced by tuak. Method : this was true experimental study with pretest-posttest with control group design. Result : Based on data in hypothesis test from Wilcoxon test and Mann-Whitney test, there were an effect of honey in mean of total cholesterol level and triglyceride that was showed by reduction of total cholesterol level and triglyceride with p<0,05.. Conclusion : there were an effect of honey in total cholesterol level and triglyceride from Wistar male white rat (Rattus norvegicus L) induced with tuak.
Pemberdayaan Ibu Pengajian Sebagai Upaya Pencegahan Kanker Serviks di Kota Medan Mirhalina, Siti; Lubis, Humairah Medina Liza; Purwoningsih, Emni
ABDI SABHA (Jurnal Pengabdian kepada Masyarakat) Vol 1, No 1 (2020): Oktober
Publisher : ABDI SABHA (Jurnal Pengabdian kepada Masyarakat)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53695/jas.v1i1.68

Abstract

According to Riskesdas data in 2013 in Indonesia, it is estimated that 40,000 new cases of cervical cancer are found each year. The incidence of cancer sufferers continues to increase and requires immediate treatment to prevent the continued increase in cancer death rates. This can be achieved, one of which is the right detection of cancer, both diagnosis and prognosis. The objectives of this community service are: (1) Finding cervical cancer cases that become an iceberg phenomenon and undetectable at an early stage, (2) Providing debriefing about Pap smear screening programs in Medan that do not run routinely or are not even carried out (3 ) Providing information on the importance of Pap smears in women of reproductive age,  (4) Empowering cadres in this case the members of the Istiqomah Mosque study in each neighborhood in Pahlawan Village as a system of coordination in treating cervical cancer in their respective work areas. Of the 30 people who had Pap smear tests, none of them found suspicious results, only in the form of inflammation of the cervix which could be treated with antibiotics. Keywords: members of Istiqomah mosque, prevention, cervical cancer  
Pembekalan Pasien Tuberkulosis Tentang Bahaya Resistensi Multipel Obat Antituberkulosis di Kota Medan Lubis, Humairah Medina Liza; Purwoningsih, Emni; Utami, Ratih Yulistika
ABDI SABHA (Jurnal Pengabdian kepada Masyarakat) Vol 1, No 1 (2020): Oktober
Publisher : ABDI SABHA (Jurnal Pengabdian kepada Masyarakat)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53695/jas.v1i1.67

Abstract

Tuberculosis (TB) is an infectious disease caused by bacterial infection Mycobacterium tuberculosis (MTB). TB infection is still a health problem in the world and Indonesia since 1989-1992 there has been an increase in this disease, which is associated with an increase in the HIV / AIDS epidemic, urbanization and migration due to the recession that hit the world. Along with the increase in this disease a new problem arises, namely TB with multiple anti-tuberculosis drug resistance (Multidrug Resistant Tuberculosis / MDR-TB). The community service objectives are (1) finding new TB patients, MDR-TB and drug cessation cases, (2) providing health debriefing about the dangers of Multiple Anti-Tuberculosis Drug Resistance to partners, (3) providing counseling about healthy food and balanced nutrition to partners , (4) empower TB health cadres and Drug Drugs Supervisors in each neighborhood in Pahlawan Village as a system of coordination in handling TB in their respective work areas. There were 30 new cases of TB and 5 cases with MDR TB that needed serious treatment from the medical staff and related health services.
PERBANDINGAN EFEKTIVITAS NEFROPROTEKTOR EKSTRAK JINTAN HITAM (NIGELLA SATIVA) DENGAN EKSTRAK TEMULAWAK (CURCUMA XANTHORRHIZA) TERHADAP GAMBARAN HISTOPATOLOGI GINJAL TIKUS (RATTUS NOVERGICUS) YANG DIINDUKSI PARASETAMOL HANDAYANI, KARTIKA; SURYANI, DES; LUBIS, HUMAIRAH MEDINA LIZA
JURNAL ILMIAH MAKSITEK Vol 6 No 2 (2021): JURNAL ILMIAH MAKSITEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Over-use of paracetamol can cause nephrotoxicity. Black cumin and curcuma contain antioxidants that can ward off freeradicals produced by paracetamol metabolism. To compare the effectiveness of nephroprotector of black cumin extract andcurcuma extract on the histopathological picture of rats induced by paracetamol. True experimental, Post Test Only ControlDesign. 24 rats were divided into 4 groups: negative control standard diet and aquades, positive group paracetamol dose500 mg / kgBB, treatment 1 extract of black cumin extract 500 mg / kgBB, and treatment 2 curcuma extract 500 mg / kgBB.After 30 minutes P1 and P2 were given a dose of paracetamol 500 mg / kg. Rats were dissected for kidney removal andhistopathological preparations were made. Degeneration, necrosis and bleeding of the proximal tubules were assessed byscoring, comparison of scores between groups was assessed by the kruskal wallis test. There were nephroprotector effectsof black cumin and curcuma, with the same effectiveness on kidney damage induced by paracetamol. Black cumin can bedeveloped further as a nephroprotector.
PREVALENSI DAN FAKTOR - FAKTOR YANG TERKAIT DENGAN PERKEMBANGAN KEJADIAN PENYAKIT TUBERKULOSIS MULTIDRUG RESISTANT DI KOTA MEDAN LUBIS, RIFQY IMSYA AL AYYUBI; LUBIS, HUMAIRAH MEDINA LIZA
JURNAL ILMIAH MAKSITEK Vol 6 No 2 (2021): JURNAL ILMIAH MAKSITEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Multidrugs resistant tuberculosis is a type of TB bacterial resistance to at least two first-line anti-TB drugs, namely Isoniazidand Rifampin which are the two most effective TB drugs.1 A global total of 186,772 cases of MDR / RR-TB were detectedand known in 2018, up from 160,684 in 2017, 156,071 cases were registered in treatment, up from 139,140 in 2017. Theestimated incidence of drug-resistant TB cases in Indonesia was 24,000 in 2018, but in 2018 only 9180 TB RR patients werefound and only 49% of TB patients were confirmed. RR initiating second-line TB treatment. The aim of this study was tocollect data on the prevalence and factors associated with the development of the incidence of multidrug resistanttuberculosis in the city of Medan. This study was a descriptive analytic study with a cross section design. The researchsample consisted of 28 MDR TB patients at Puskesmas Helvetia and RSUD Pirngadi Medan, which were taken by totalsampling method. This study was tested with the Pearson correlation test. The results of this study showed that the riskfactors for the sample of this study were male gender 15 people (53.6%), mean age above 40 years 21 people (75.0%) 26people (92.9%) married status, 25 people with high school education level (89.3%), 9 self-employed people (32.1%), monthlyincome less than 1,000,000 15 people (53.6%), history of use Previous OAT OAT line 1 (complete) 11 people (39.3%), ahistory of smoking 14 people (50.0%), a history of not consuming alcohol 23 people (82.1%), patient knowledge about MDRTB was less or bad 18 people (53.6%), patient compliance in taking medicine was good 17 people (60.7%), 16 people wereless motivated to take medication (57.1%) and the patient's daily habits were good 14 people (50.0%). The relationshipbetween several risk factors such as previous drug use history with the level of patient adherence to MDR TB, the level ofmedication adherence and motivation to take medication and vice versa. meanwhile, daily habits such as smoking andalcohol consumption had no relationship with previous history of drug use, patient adherence to MDR TB, level of medicationadherence and motivation to take medication.
EFEK PEMBERIAN REBUSAN KULIT MARKISA UNGU (PASSIFLORA EDULIS) SEBAGAI ANTIDIABETIK TERHADAP GAMBARAN HISTOPATOLOGI PANKREAS TIKUS YANG DIINDUKSI STREPTOZOTOSIN KHOIROT, USWATUL; PURWONINGSIH, EMNI; LUBIS, HUMAIRAH MEDINA LIZA; SEPTINA, LITA
JURNAL ILMIAH KOHESI Vol 5 No 1 (2021): JURNAL ILMIAH KOHESI
Publisher : LP2MTBM MAKARIOZ

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Abstract

DM is one of the greatest health problems around the world. Nowdays, we found many studies proved many plants whichcontain antioxidant have a potential as antidiabetic. Antioxidants are able to repair oxidative stress in pancreatic beta cellsthat overcome pancreatic tissues damage. One of the plant that contains rich antioxidant is purple passion fruit ( Passifloraeduils). This study used True Experimental method, with Post –Test Only Control Group Design, which only gave anobservation to a control group after being given a treatment. The sample of this study was white Wister strain male rats(Rattus Norvegisus L). The statistic study of this research used Kruskal Wallis and Mann-Whitney with a significance level ofp > 0,05, because the data were not normally distributed. Pancreatic histopathology improvement in the first treatment groupshowed a non-significant difference compared with positive controlled group (p< 0, 05). Pancreatic histopathologyimprovement in the second treatment group showed a significant different compared with positive controlled group(p< 0, 05). There was an effect of giving purple passion fruit skin decoction (Passiflora eduils) as anti-diabetic to the ratpancreas histopathology that inducted by streptozotosin.
HUBUNGAN KOINFEKSI TUBERKULOSIS DAN HUMAN IMMUNODEFICIENCY VIRUS (HIV) SERTA KAITANNYA DENGAN MULTI DRUG RESISTANT TUBERCULOSIS (MDR-TB) DI KOTA MEDAN TAHUN 2019 HENDEWI, ANNISA FITRI; LUBIS, HUMAIRAH MEDINA LIZA
JURNAL ILMIAH KOHESI Vol 5 No 3 (2021): JURNAL ILMIAH KOHESI
Publisher : LP2MTBM MAKARIOZ

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Abstract

Tuberculosis the infectious disease found most commonly in Human Immunodeficiency Virus (HIV) infection. Increase of coinfectionTB-HIV is the main cause of Drug Resistance TB in Indonesia. High mortality of TB-HIB in the world and Indonesiawith Increase MDR-TB case. This study used descriptive analytical method with retrospective design. Data processed useFisher Exact Test. The result showed that the relationship of TB-HIV with MDR-TB at Medan in 2019 show p value of 0.026(p<0.05). There is a significant relationship between the co-infection TB-HIV with MDR-TB at Medan in 2019.
ANTIINFLAMASI NANOPARTIKEL BUAH ANDALIMAN (ZANTHOXYLUM ACANTHOPODIUM DC.) PADA ATEROSKLEROSIS : INTERAKSI ENDOTELIAL HSP70 AHMAD, DIWA AULIA; ARMADI, IBNU AFIF; FITHRIYAH, KHAIRATUL; LUBIS, HUMAIRAH MEDINA LIZA
JURNAL ILMIAH SIMANTEK Vol 5 No 2 (2021): JURNAL ILMIAH SIMANTEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

This study aims to determine the effect and potential mechanism with the treatment of nanoparticles from andaliman fruit(Zanthoxylum acanthopodium DC.) As an anti-inflammatory in atherosclerosis through the HSP70 route. Method, andalimanfruit dried in an oven at a temperature of 40ºC and powdered with nano technology using a High Energy Ballmill. This studyused 27 rat samples which were divided into 3 groups. The examination was carried out by routine histopathologicalexamination procedures for the assessment of atherosclerosis and immunohistochemistry HSP70. Assessment of HSP70immunoreactive cells is indicated by the expression of cells that appear reddish brown in the intima and endothelial media ofblood vessels. The result, of the total 27 samples found 8 atherosclerosis (29.7%) and 19 did not experience atherosclerosis(70.3%). The difference in HSP70 expression in the positive control group and the treatment group was statistically testedwith Chi Square and the result was p = 0.007 (p <0.05). Conclusion, the administration of Andaliman fruit nanoparticles hasan effect on the repair of blood vessel endothelium in atherosclerosis which is assessed by an increase in HSP70expression.