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RANDOMIZED CLINICAL TRIAL OF OMEPRAZOLE AND RANITIDINE USING INDONESIAN TRANSLATED NEPEAN DYSPEPSIA INDEX Arinton, I Gede; Samudro, Pugud; Sutrisna, Eman; IDN, Wibawa
journal of internal medicine Vol. 7, No. 3 September 2006
Publisher : journal of internal medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (93.923 KB)

Abstract

In patients with dyspepsia, a common initial management strategy in primary care is to prescribe a course ofempiric antisecretory therapy. Ranitidin and omeprazole as antisecretory agents have been proven effective fortreatment of dyspepsia. This research was aimed to evaluate the effect of omeprazole and ranitidine by using NepeanDyspepsia Index (NDI) which was translated and validated in Indonesian language. Fifty healthy persons were askedto complete the Indonesia translated NDI(NDII) and Short Form(SF)- 36, which was previously validated. Cronbach' salpha and test-retest were performed for reliability analysis. Spearman's rank correlation was used to assess validity. P-value <0.03 was considered statistically significant. The results concluded that NDIl can be used in dyspepsia patientswho understand Indonesian language. The number of 104 subjects with a clinical diagnosis of dyspepsia according tothe inclusion and exclusion criteria were recruited and randomized to receive ranitidine 150 mg twice daily andomeprazole 20 mg twice daily. Symptoms of dyspepsia were evaluated by using NDIl at baseline one week aftertreatment. The outcomes of omeprazole and ranitidine were evaluated by comparing improved NDIl score in 5domains (tension, activities, eating/drinking, knowledge/control and work/study). The mean of age in the subjects was47 years old that consisted of 36% male. After one week treatment, the NDIl dyspepsia patients score in omeprazoletreated group was not significantly different from that in ranitidine treated group. The effect of omeprazole was notbetter than ranitidine when it was given as empirical treatment for dyspepsia patients in primary care.
The protective effect of celery (Apium graveolens L.) ethanol extract on anemia in 5/6 subtotal nephrectomy rat model Afifah, Afifah; Muflikhah, Khusnul; Lestari, Tri; Sutrisna, Eman; Kirana, Ajeng; Prastiwi, Sindy Devi
Universa Medicina Vol 39, No 1 (2020)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (553.807 KB) | DOI: 10.18051/UnivMed.2020.v39.12-18

Abstract

BackgroundAnemia is a frequent complication of chronic kidney disease (CKD). Anemia in CKD is associated with reduced quality of life, increased cardiovascular disease, cognitive impairment, and mortality. Therefore it is necessary to find an alternative agent for preventing anemia in CKD. Celery is one of the natural substances that have anti-inflammatory, antioxidant, and antihypertensive pharmacological effects. Based on the mechanism of CKD and its progression, celery is thought to prevent anemia in CKD. This research was aimed at evaluating the protective effect of celery extract against anemia in a CKD rat model. MethodsThis was an experimental laboratory study using 25 male Sprague Dawley rats, aged 2-3 months, they were randomized into 5 groups, namely group A, sham operation; group B, subtotal nephrectomy; group C, D, E, subtotal nephrectomy + 250, 500, 1000 mg/kg BW ethanol extract of celery, respectively. The administration of celery extract was performed 14 days before and 14 days after induction of 5/6 subtotal nephrectomy. The hematological parameters (Hb, RBC, Ht, MCV, MCH, MCHC) and serum creatinine level were measured at the end of the study. Data were analyzed with One Way ANOVA and Kruskal-Wallis test followed by Mann-Whitney test at p<0.05. ResultsThere were no significant differences between groups in Hb, RBC, Ht, MCV (p>0.05) and significant differences between groups in MCH and MCHC (p<0.05). The highest levels of Hb, RBC, and Ht were found in group C.ConclusionCelery ethanol extract at a dose of 250 mg/kg BW/day may prevent anemia in the CKD rat model.
Pengaruh Frekuensi Vibrasi terhadap Penyembuhan Luka Diabetes Sari, Yunita; Sutrisna, Eman; H, Hartono
Jurnal Keperawatan Padjadjaran Vol 4, No 2 (2016): Jurnal Keperawatan Padjadjaran
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1077.792 KB) | DOI: 10.24198/jkp.v4i2.232

Abstract

Penelitian menyatakan bahwa vibrasi 47 Hz dapat meningkatkan penyembuhan luka diabetes. Namun sampai saat ini belum diketahui apakah frekuensi dibawah dan diatas 47 Hz dapat meningkatkan penyembuhan luka diabetes. Oleh karena itu, tujuan dari penelitian ini adalah untuk mengetahui efek frekuensi vibrasi yang berbeda terhadap penyembuhan luka diabetes. Desain penelitian eksperimen ini melibatkan 5 kelompok tikus putih; kelompok yang mendapatkan vibrasi 40 Hz (frekuensi rendah), kelompok 106 Hz (frekuensi menengah), kelompok 200 Hz (frekuensi tinggi), kelompok 300 Hz (frekuensi sangat tinggi), dan kelompok kontrol (tanpa vibrasi). Induksi diabetes dilakukan dengan Alloxan Monohidrat. Vibrasi diberikan selama 10 menit. Status luka didasarkan pada jaringan nekrotik, ukuran luka, inflamasi, dan reepitelisasi. Analisis histologi dilakukan dengan pewarnaan Hematoksilin dan Eosin. Ukuran luka dianalisis dengan uji ANOVA, diikuti oleh tes Tukey. Hasil penelitian menunjukkan bahwa jaringan nekrotik dan intensitas inflamasi paling sedikit pada kelompok 40 Hz, dan paling banyak pada kelompok 300 Hz. Reepitelisasi paling baik pada kelompok 40 Hz, dan paling rusak pada 300 Hz. Ukuran luka di kelompok 40 Hz secara signifikan lebih kecil dibandingkan dengan kelompok lain (p <0.05). Hasil penelitian ini menunjukkan bahwa vibrasi frekuensi rendah dapat mempercepat penyembuhan luka diabetes, sebaliknya, vibrasi frekuensi tinggi dapat merusak atau memperparah jaringan luka.Kata kunci :Diabetes, penyembuhan, luka, terapi komplementer, vibrasi.The Provision of Different Vibration Frequency to Accelerate Diabetic Wound HealingAbstractStudies have revealed that diabetic wound healing can be accelerated using the vibration therapy of 47 Hz. However, no strong evidence compelled the use of different vibration rates. Thus, this experimental study aimed to examine the effect of different vibration frequencies towards diabetic wound healing. Five groups of white rats were injected using Alloxan Monohydrate within ten minutes before the vibration therapy. The dosage was given categorized as 40 Hz (low), 106 Hz (moderate), 200 Hz (high) and 300 Hz (very high). Control group was created without given vibration therapy. Wound status was evaluated using the presence of necrotic tissues, size, inflammation, and reepithelization where Hematoxicilin and Eosin color-based were used to analyse the histological presentation. Using ANOVA and Tukey test, it was found that the necrotic tissues and the intended inflammation have less developed among low vibration group compared to others. Reepithelization and wound size reduction most experienced by the lower group, but the worst damaged occupied by the highest vibration group. It is suggested that lower vibration frequency enabled to accelerate the wound care healing, but a high-frequency rate can disturb or damage the injured tissues. Keywords:Complementary therapy, diabetes mellitus, wound healing.
A COMPARATIVE STUDY OF THE EFFECTS OF VIBRATION AND ELECTRICAL STIMULATION THERAPIES ON THE ACCELERATION OF WOUND HEALING IN DIABETIC ULCERS Sari, Yunita; Saryono, S.; Sutrisna, Eman; Hartono, H.
Jurnal Ners Vol 12, No 2 (2017): October 2017
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (675.654 KB) | DOI: 10.20473/jn.v12i2.4460

Abstract

Introduction: Diabetic ulcers accompanied by ischemia is difficult to treat. Such ulcers require therapy that can improve the blood flow. Previous studies have revealed that two therapies could improve blood flow and accelerate the healing of diabetic ulcers; vibration and electrical stimulation (ES). However, it is unknown which of these two therapies is best at accelerating wound healing in diabetic ulcers. The purpose of this study was to compare both therapies in relation to accelerating the wound healing of diabetic ulcers.Methods: This study was an experimental study involving diabetic rats. The rats were divided into two groups: vibration and ES. Vibration and ES were applied for 10 minutes per day for 7 days. Wound size, inflammation, intensity of fibroblast infiltration, area of necrosis and degree of re-epithelialisation were compared. The difference in wound size was analysed using an independent t-test, while the histological data were analysed using a Mann-Whitney U-test.Results: On day 5 onwards, there was a thin slough in the ES group which was not present in the vibration group. Day 4 onwards and the wound size was significantly smaller in the vibration group than in the ES group. The intensity of inflammation was significantly less, and the degree of fibroblast infiltration was significantly higher in the vibration group compared with the ES group. Re-epithelialisation was more advanced in the vibration group than the ES group.Conclusion: Our study revealed that wound healing in diabetic ulcers following vibration was better than after ES. We suggest that nurses should use vibration rather than ES in clinical settings.
EFEK HEPATOPROTEKTIF EKSTRAK ETANOL DAUN SENDOK (Plantago major L) PADA TIKUS MODEL HEPATOTOKSIK : TINJAUAN ANATOMI DAN HISTOPATOLOGI Sutrisna, Eman; Fitriani, Annisa A; Setiawati, Setiawati; Salim, Islimsyaf A; Maskoen, Ani M
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 10 No. 01 Juli 2013
Publisher : Fakultas Farmasi, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pji.v10i1.771

Abstract

ABSTRAK Hepar merupakan organ yang berisiko mengalami kerusakan akibat berbagai obat maupun bahan kimia lingkungan yang masuk ke dalam tubuh dan dapat menimbulkan gangguan metabolisme dan homeostasis sistemik. Daun sendok (Plantago major L.) mengandung senyawa aktif yang memiliki efek antiinflamasi, antiapoptosis, antiproliferatif, antioksidan dan hepatoprotektif. Penelitian ini bertujuan untuk menganalisis efek pemberian ekstrak etanol daun sendok terhadap penurunan volume, massa dan perbaikan gambaran histopatologi hepar tikus Wistar (Rattus norvegicus) model hepatotoksik. Penelitian berupa eksperimental dengan desain post test only with control group design. Sebanyak 21 ekor tikus wistar (Rattus norvegicus) dibagi menjadi 3 kelompok perlakuan. Kelompok kontrol sehat (K0) diberi akuades, kelompok kontrol negatif (K1) diberi omeprazol dosis 10 mg/200 g BB tikus dan ciprofibrat 16 mg/200 gBB tikus/hari, dan kelompok intervensi (K2) diberi omeprazol dosis 10 mg/200 g BB tikus, ciprofibrat 16 mg/200 g BB tikus/hari, dan ekstrak etanol daun sendok 100 mg/200 g BB tikus. Derajat kerusakan hepar ditentukan menggunakan skor Manja Roenigk. Semua hewan coba dikorbankan dibawah pengaruh anestesi setelah perlakuan selama 2 bulan. Organ liver hewan coba diambil untuk pemeriksaan massa, volume dan histopatologi liver. Data massa dan volume hepar dianalisis secara statistika dengan Uji Kruskal- Wallis, dilanjutkan uji beda Mann-Whitney serta uji one way ANOVA untuk menganalisis perbedaan gambaran histopatologi hepar, dilanjutkan uji pos hoc. Terdapat perbedaan bermakna rerata massa hepar, volume dan skor Manja roenigk antar kelompok perlakuan (nilai p=0,000; 0,001; 0,000; α
Pemberdayaan Kader Posyandu Lansia Untuk Pencegahan Hipertensi dan Komplikasinya di Purwokerto Sari, Yunita; Sumarwati, Made; Sutrisna, Eman
Jurnal Pengabdian Pada Masyarakat Vol 3 No 1 (2018)
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (829.633 KB) | DOI: 10.30653/002.201831.49

Abstract

EMPOWERMENT OF ELDERLY POSYANDU CADRES FOR PREVENTING HYPERTENSION AND ITS COMPLICATION IN PURWOKERTO. The highest prevalence of degenerative diseases in Banyumas regency is hypertension. The prevention of hypertension in elderly could be done by Elderly Posyandu. However, there are many problems which occur in Elderly Posyandu of Soka Nirmala III and Sejahtera II in preventing hypertension and its complication, such as the limitation of materials for blood pressure measurement, lack of knowledge for hypertension management, lack of knowledge about self-treatment for reducing blood pressure. The purposes of this programme were to give kits for hypertension measurement to elderly posyandu, to conduct training of hypertension prevention, training about diet management, training about elderly exercise, training about self-treatment for reducing blood pressure. This community service was done through health education, training, and simulation. This community service could improve the knowledge of cadres and elderly in managing hypertension, improve knowledge in conducting exercise for reducing hypertension, improve knowledge in diet management, and improve the knowledge about self-treatment for reducing hypertension. It is expected that the prevalence of hypertension and its complication could be reduced and the quality of life of elderly could be improved.
Comparison of the Effect of Ethanol Extracts of Phaleria macrocarpa (scheff.Boerl) Fruit and Metformin on the Kidney Function of Hyperglycaemic Rat Models sutrisna, Eman; Sutrisna, Eman; Gumilas, Nur Signa Aini; topa, Mus; Sulistyoningrum, Evy
Herb-Medicine Journal Vol 3, No 2 (2020): Herb-Medicine Journal Juli 2020
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v3i2.6656

Abstract

Diabetes mellitus is a disease that often causes diabetic nephropathy complications due to persistent hyperglycaemia. Phaleria macrocarpa (scheff. Boerl)  is one of the plants that has been widely used in the treatment of diabetes mellitus, but its effect on the risk of diabetic nephropathy is still unknown. A dose of 300mg / 200gbb / day is known as an effective dose that can significantly reduce blood sugar levels in diabetic rat. The Streptozotocin Effect (STZ) causes damage to the pancreas and causes hyperglycaemia. This study aims to compare the effect of Phaleria macrocarpa (scheff. Boerl) fruit extracts on urea and creatinine levels as a parameter of kidney function in hyperglycaemic mouse models. The study was carried out experimentally using the post-test only with control group design. Fifteen white rats were divided into 3 groups. All rats were induced with 40 mg / 200gbb of Streptozotocin (STZ) to experience hyperglycaemia. Group I as negative control was given aquades. Group II was given ethanol extract of Phaleria macrocarpa (scheff. Boerl) with a dose of 300 mg / 200gbw / day. Group III was given Metformin at a dose of 150 mg / 200gbw / day. On the 22nd day of treatment, blood specimens were taken for examination of urea and creatinine levels. The research data were statistically analyzed with α <0.05; CI95%. The mean of urea levels in Group I (79.80 ± 25.09 mg / dl), II (76.00 ± 22.59 mg / dl and III (59.60 ± 6.35 mg / dl). Kruskal-Wallis test results showed no significant difference in urea levels between treatment groups (p value = 0.273; CI95%). The mean of creatinine levels in Group I (0.68 ± 0.07 mg / dl), II (0.63 ± 0.14 md / dL) and III (0.98 ± 0.25 mg / dL). One Way Anova and Post hoc test results showed a significant difference in mean creatinine levels between Groups I and III (p = 0.014; 95% CI) and II with III ( p value = 0.006; CI95%). the results of this study can be concluded that the extract of Phaleria macrocarpa (scheff. Boerl) fruit flesh at a dose of 300 mg / 200gbb has better effectiveness than metformin dose 150 mg / 200gbb in repairing the kidney function of hyperglycaemia rats.
Comparison of the Effect of Ethanol Extracts of Phaleria macrocarpa (scheff.Boerl) Fruit and Metformin on the Kidney Function of Hyperglycaemic Rat Models sutrisna, Eman; Sutrisna, Eman; Gumilas, Nur Signa Aini; topa, Mus; Sulistyoningrum, Evy
Herb-Medicine Journal Vol 3, No 2 (2020): Herb-Medicine Journal Juli 2020
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v3i2.6656

Abstract

Diabetes mellitus is a disease that often causes diabetic nephropathy complications due to persistent hyperglycaemia. Phaleria macrocarpa (scheff. Boerl)  is one of the plants that has been widely used in the treatment of diabetes mellitus, but its effect on the risk of diabetic nephropathy is still unknown. A dose of 300mg / 200gbb / day is known as an effective dose that can significantly reduce blood sugar levels in diabetic rat. The Streptozotocin Effect (STZ) causes damage to the pancreas and causes hyperglycaemia. This study aims to compare the effect of Phaleria macrocarpa (scheff. Boerl) fruit extracts on urea and creatinine levels as a parameter of kidney function in hyperglycaemic mouse models. The study was carried out experimentally using the post-test only with control group design. Fifteen white rats were divided into 3 groups. All rats were induced with 40 mg / 200gbb of Streptozotocin (STZ) to experience hyperglycaemia. Group I as negative control was given aquades. Group II was given ethanol extract of Phaleria macrocarpa (scheff. Boerl) with a dose of 300 mg / 200gbw / day. Group III was given Metformin at a dose of 150 mg / 200gbw / day. On the 22nd day of treatment, blood specimens were taken for examination of urea and creatinine levels. The research data were statistically analyzed with α <0.05; CI95%. The mean of urea levels in Group I (79.80 ± 25.09 mg / dl), II (76.00 ± 22.59 mg / dl and III (59.60 ± 6.35 mg / dl). Kruskal-Wallis test results showed no significant difference in urea levels between treatment groups (p value = 0.273; CI95%). The mean of creatinine levels in Group I (0.68 ± 0.07 mg / dl), II (0.63 ± 0.14 md / dL) and III (0.98 ± 0.25 mg / dL). One Way Anova and Post hoc test results showed a significant difference in mean creatinine levels between Groups I and III (p = 0.014; 95% CI) and II with III ( p value = 0.006; CI95%). the results of this study can be concluded that the extract of Phaleria macrocarpa (scheff. Boerl) fruit flesh at a dose of 300 mg / 200gbb has better effectiveness than metformin dose 150 mg / 200gbb in repairing the kidney function of hyperglycaemia rats.
The Comparative Effectiveness of Phaleria macrocarpa (Scheff.) Boerl. Pericarp Ethanol Extract and Metformin in Reducing Blood Sugar Levels and Ameliorating the Langerhans Islets Degeneration in Diabetic Rat Models Sutrisna, Eman; Aini, Qurrotu; Harini, Ika Murti; Gumilas, Nur Signa Aini; Mustofa, Mustofa; Sulistyoningrum, Evy
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 01 Juli 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i1.6526

Abstract

Phaleria macrocarpa (Scheff.) Boerl. has been widely used in the treatment of diabetes mellitus but its effectiveness is still inconclusive so it needs to be compared with standard drugs such as metformin. This study aims to analyze the effects of P. macrocarpa fruit extracts on blood sugar levels and the repairing of the pancreatic Langerhans islets of diabetic rat models. The study was conducted experimentally by pre and post-test design with a control group. Thirty white rats were divided into 6 groups. All rats were treated with 40 mg/200 g BW of streptozotocin (STZ) to induce hyperglycemia, except group I. Group II as a negative control was given with aquadest. Group III, IV, and V were given with ethanol extract of P. macrocarpa pericarps at doses of 200, 250, and 300 mg/200 g BW/day, respectively. Group VI was given with metformin at a dose of 150 mg/200 g BW/day. On the 22nd day of treatment, blood specimens were taken for examination of fasting blood sugar levels and pancreatic organs were analyzed for histopathological examination of the islets of pancreatic Langerhans. The data were statistically analyzed with α<0.05; CI95%. Paired sample t-test results showed a significant decrease in blood sugar levels before and after treatment in group V (p-value=0.048). One way anova and post hoc Least Significant Difference (LSD) test results showed a significant difference in mean blood sugar levels after the final treatment between groups I and II (p-value=0.013), I and III (p-value=0.004), I and IV (p-value=0.002), I and VI (p-value=0.000), II and VI (p-value=0.031), and V with VI (p-value=0.005); one way anova and post hoc LSD test results showed a significant difference in the mean area of islets of pancreatic Langerhans between group I and all treatment groups (p-value=0.000), II with V and VI (p-value=0.000 and 0.009), III with V and VI (p-value=0.000 and 0.001), and IV with V (p-value=0.003). It can be concluded that the extract of P. macrocarpa pericarps showed a hypoglycemic effect and repaired the damage in Langerhans islets of STZ-induced rat in a dose-dependent manner.