Bagus Soebadi, Bagus
Departemen Ilmu Penyakit Mulut, Fakultas Kedokteran Gigi, Universitas Airlangga, Surabaya, Jawa Timur, Indonesia

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Human-leukocyte antigen typing in Javanese patients with recurrent aphthous stomatitis Ernawati, Diah Savitri; Soebadi, Bagus; Radithia, Desiana
Dental Journal (Majalah Kedokteran Gigi) Vol 43, No 1 (2010): March 2010
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (392.658 KB) | DOI: 10.20473/j.djmkg.v43.i1.p26-30

Abstract

Background: Recurrent aphthous stomatitis (RAS) is a common oral disorder that despite extensive researches, the etiology of this phenomenon is still unknown. Because this phenomenon has been observed more often in families than in individual cases, genetic influence has been investigated in most researches. Purpose: The aim of study was to evaluate the association between human leukocyte antigen (HLA) and RAS in Javanese more precisely. Method: The analysis of HLA-A, and HLA-B in 85 Javanese RAS patients and 71 healthy control subjects, were performed by using the standard NIH microlymhocytotoxicity technique. Immunohistochemistry was performed for identification of HLA-DR and HLA- DQ antigen using monoclonal antibodies anti HLA-DR and DQ. Result: Our result revealed a close association between HLA-A9 and HLA-B35 RAS subject. A significant increase in the frequency of some antigens such as HLA-A9 (72,94%, p < 0,05;RR = 2,21), HLA-A24 (65,82%; RR = 1,24) and HLA-B35 in subjects with RAS was observed. Analysis with Immunohistochemistry HLA-DR, HLA-DQ is expressed on the surface of epithelial cells membrane of oral mucosa and macrophages in both major and minor RAS patients. Conclusion: HLA antigens are involved in susceptibility to RAS and the phenotypes were difference with other previous studies. HLA- linked genetic factors may play a role in the development of RAS.Latar belakang: Stomatitis aftosa rekuren (SAR) merupakan salah satu gangguan di rongga mulut yang paling sering terjadi. Fenomenapenyakit ini masih belum jelas dan masih membutuhkanpenelitian yang lebih lanjut. Faktor keturunan lebih sering daripada kasus individual. Pengaruh faktor genetik telah diteliti oleh beberapapeneliti. Tujuan: Tujuan penelitian ini untuk mengetahui adanya kaitan HLA dengan SARpada suku jawa secara lebih tepat. Metode: Analisis HLA-A, HLA-Bpada 85penderita RAS dan 71 penderita kontrol yang berasal dari suku Jawa dihitung dengan menggunakan teknik NIH Micro Lymphocytotoxicity. Teknik Imunohistokimia dilakukan untuk mengidentifikasi antigen HLA-DR, HLA DQ dengan menggunakan antibodi monoklonal HLA-DR & DQ. Hasil: Menununjukkan hubungan yang kuat antara HLA-A9 dan HLA-B-35 pada pasien SAR. Terdapat peningkatan yang signifikan dari beberapa antigen seperti HLA-A9 (72,94%, p < 0,05, RR = 2,21), HLA-A24 (65,82%, RR = 1,24) dan HLA-B35 pada pasien SAR yang di observasi. Analisis dengan Imunohistokimia tampak HLA-DR, DQ diekspresikan pada permukaan membran sel dan makrofag pada pasien SAR mayor maupun minor. Kesimpulan: Antigen HLA terlibat dengan kepekaan terjadinya RAS, dan fenotipnya berbeda dengan hasil penelitian sebelumnya HLA dan faktor genetik berperan penting pada terjadinya SAR.
Profil Angular Cheilitis pada penderita HIV/AIDS di UPIPI RSUD Dr. Soetomo Surabaya 2014 Nugraha, Alexander Patera; K, Mintarsih Djamhari; P, Adiastuti Endah; Soebadi, Bagus; Triyono, Erwin Asta; Prasetyo, Remita Adya; Budi, Sulistyowati
Majalah Kedokteran Gigi Indonesia Vol 1, No 1 (2015): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1036.707 KB) | DOI: 10.22146/majkedgiind.9032

Abstract

Profile of Angular Cheilitis in HIV/AIDS Patients at UPIPI RSUD Dr. Soetomo Surabaya 2014. For over twenty years, human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) have become a significant public health concern, and the epidemic continues to challenge humanity. HIV related oral lesions can be used as markers of the immune status. Angular Cheilitis (AC) which is one of the seven oral manifestations which are strongly associated with HIV Infection, has been identified and internationally calibrated. The purpose of this research is to identify the Angular Cheilitis and its association with reduced Cluster of Differentiation 4 (CD4+) count in HIV/AIDS patients at Unit Perawatan Intermediet Penyakit Infeksi (UPIPI) RSUD Dr. Soetomo Surabaya. This was an Analytic observasional research with cross-sectional and total sampling method. The samples consisted of 88 HIV/AIDS patients treated in UPIPI RSUD Dr. Soetomo Surabaya from July to August 2014. The Diagnosis of Angular Cheilitis was based on clinical appearance; the oral cavities of the research subjects were examined by dentists specialized in Oral Medicine. CD4+ counts were obtained from the patient’s medical record. Eighty Eight HIV/AIDS patients were examined and there were 120 cases of oral manifestation. There were 31 cases of Angular Cheilitis (25,83%). Angular Cheilitis was found to be significantly correlated to the decrease in CD4+ cell count below 200 cells/mm3 (P< -,245). Risk Relative anaylsis concludes that HIV/AIDS patients with Candidiasis Oral 7.5 more often suffer from AC. There is a correlation between AC and OC (p<0,357). Angular Cheilitis may be used as an alternative to predict CD4+ count at field-based settings to diagnose the immunocompromised status of HIV-infected individuals.
Penatalaksanaan chronic atrophic candidiasis pada pasien gigitiruan lepasan Apriasari, Maharani Laillyza; Soebadi, Bagus
Journal of Dentomaxillofacial Science Vol 8, No 2 (2009): Formerly Jurnal Dentofasial ISSN 1412-8926
Publisher : DiscoverSys Inc

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Abstract

Chronic atrophic candidiasis is the pathologic changes on the oral mucous of thedenture wearers, accompanied with erythematous under the denture, usuallyasymptomatic and relates to the yeast of Candida. The irritation factors of chronicatrophic candidiasis are ill fitting denture, using the denture at night and bad oralhygiene. This is a case report of chronic atrophic candidiasis on patient usingremovable denture without systemic disease. The trigger factors were using denture atnight, mistaken of cleaning the denture and dental calculus surround the artificialteeth of denture. Final diagnosis is based on anamnesis, clinical examination andmicrobiology examination. Therapy given was a topical antifungal appliedcontinuously for 7 days after the clinical signs dissapear. The patient was suggested tonot using the denture at night, maintain the cleanliness of the denture regularly andscaling the teeth. It can be concluded that management of chronic atrophiccandidiasis is based on the oral lesion condition, oral hygiene, wearing denture atnight, and the systemic condition.
Penatalaksanaan infeksi herpes simpleks oral rekuren Management of recurrent oral herpes simplex infection Marlina, Erni; Soebadi, Bagus
Journal of Dentomaxillofacial Science Vol 12, No 1 (2013): Formerly Jurnal Dentofasial ISSN 1412-8926
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v12i1.345

Abstract

Recurrent oral herpes simplex infection was the secondary or recurrent form of primary herpes simpex infection. Inhuman, herpes simplex virus was latent or dormant and could reactivate. Recurrency due to virus reactivation inducedby emotional stress, high fever, ultraviolet exposed, oral tissue or neuron tissue trauma, immunosuppresion condition,and hormonal disturbance. The aim of this paper was to report and discuss management of recurrent oral herpessimplex infection which complicated in the diagnosis due to manifestation of both herpes labialis and intraoral lesionform resembling herpes simplex infection. Patient was a 22 years- old woman, came to Installaton of Dental, dr.Soetomo Hospital with chief complaint pain were soreness caused by ulcer on the tongue accompanied by tingling nearthe upper labial mucosal. Patient was prescribed with acyclovir as causative therapy, mouthwash contain extract ofaloe vera, multivitamins and immunomodulator as supportive therapy. Patient healed 4 days after the first visit. It wasconcluded that this case was diagnosed clinically as recurrent oral herpes simplex infections. Causative therapy withacyclovir administration showed excellent response, as well as supportive therapy immunomodulator that supportedimprovement of the immune system so that the frequency of recurrence can be reduced.
Sensitivity difference of Streptococcus viridans on 35% Piper betle linn extract and 10% povidone iodine towards recurrent apthous stomatitis Apriasari, Maharani Laillyza; Soebadi, Bagus; Hendarti, Hening Tuti
Dental Journal (Majalah Kedokteran Gigi) Vol 44, No 3 (2011): (September 2011)
Publisher : Faculty of Dental Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (539.967 KB) | DOI: 10.20473/j.djmkg.v44.i3.p159-163

Abstract

Background: Oral ulceration often becomes the main reason for the patients to see a dentist. Therapy of the oral ulceration is by giving the palliative therapy with topical antiseptic. Nowadays, there are many researches concerning with the traditional medicines as alternative therapy. One of them is Piper betle linn which contains the antiseptic agent. Purpose: This research is aimed to observe the sensitivity difference of Streptococcus viridans on 35% Piper betle linn extract and 10%povidone iodine. Methods: This laboratory research was conducted by the post test only design with random complete design. The research sampel is Streptococcus viridans culture that was scrapped from the ulcer of the recurrent aphthous stomatitis patient, then it was replicated by using the Federer theory. Results: Inhibitory zone of 35% Piper betle linn extract is bigger than 10% povidone iodine. Conclusion: Streptococcus viridans are more sensitive to 35% Piper bittle linn extract than 10% povidone iodine. 35% Piper betle linn extract has more antibacterial effect than 10% povidone iodine.Latar belakang: Ulserasi rongga mulut seringkali menjadi alasan utama bagi pasien untuk memeriksakan diri ke dokter gigi. Terapi ulserasi rongga mulut adalah pemberian terapi paliatif kepada penderita, seperti: pemberian obat topikal yang mengandung antiseptik. Saat ini banyak penelitian dalam pengembangan obat tradisional yang dapat dijadikan sebagai obat alternatif. Salah satu diantaranya adalah daun sirih yang mengandung zat antiseptik. Tujuan: Penelitian ini bertujuan mengetahui perbedaan sensitivitas Streptococcus viridans terhadap ekstrak daun sirih 35% jika dibandingkan dengan povidone iodine 10%. Metode: Penelitian laboratoris yang dilakukan dengan post test only design dengan rancangan acak lengkap. Sampel penelitian adalah kultur Streptococcus viridans yang diambil melalui swab dari hapusan ulser pada pasien yang menderita stomatitis aftosa rekuren, kemudian dilakukan replikasi dengan rumus Federer. Hasil: Zona hambat ekstrak daun sirih 35% lebih besar daripada zona hambat povidone iodine 10%. Kesimpulan: Streptococcus viridans lebih sensitif terhadap ekstrak daun sirih 35%. Ekstrak daun sirih 35% memiliki efek daya antibakteri yang lebih tinggi jika dibandingkan dengan povidone iodine 10%.
Prevalence of xerostomia on type 2 diabetes mellitus in Hajj Hospital Surabaya Harijanti, Kus; Soebadi, Bagus; Mulyaningsih, Irvanda
Dental Journal (Majalah Kedokteran Gigi) Vol 40, No 3 (2007): September 2007
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (119.852 KB) | DOI: 10.20473/j.djmkg.v40.i3.p136-139

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Diabetes Mellitus (DM) is a chronic disorder of carbohydrate, fat and protein metabolism. A defective or deficient of the insulin secretory, which is translated into impaired carbohydrate (glucose) use, is characteristic feature of DM, as the resultant is hyperglycemia. There is variability among patients, however, morphologic changes are likely found in arteries (atherosclerosis), basement membrane of the blood vessel wall tissues (micro angiopathy), kidneys (diabetic nephropathy), retina (retinopathy), nerves (neuropathy) and other tissues. If it involves salivary glands, the clinical sign is xerostomia. The type 2 of DM is caused by a combination of peripheral resistance to insulin action and an inadequate secretory response of the pancreatic b-cell. Approximately 80% to 90% of patients have type 2 diabetes. The purpose of this study was to determine the prevalence of xerostomia and its relation with level of blood glucose in type 2 DM. The data was taken using cross sectional method on the diabetic patients of Internal Medicine clinic, Hajj Hospital Surabaya from February to March 2006. The result that showed among 50 samples of the type 2 DM, the prevalence of xerostomia were 38 patients (76%). Most of the patients (32 patients = 84%) on bad regulation of DM with level of fasting glucose ≥ 126 mg/dl and level of post prandial glucose ≥ 180 mg/dl. The study showed that bad regulation of type 2 DM could develop complication on salivary glands, with xerostomia as the clinical sign.
Oral rinse as a potential method to culture Candida isolate from AIDS patients Radithia, Desiana; Hendarti, Hening T.; Soebadi, Bagus
Dental Journal (Majalah Kedokteran Gigi) Vol 44, No 4 (2011): (December 2011)
Publisher : Faculty of Dental Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (411.327 KB) | DOI: 10.20473/j.djmkg.v44.i4.p177-180

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Background: Candida isolate is easily sampled from oral cavity by swabbing directly on the candidiasis lesion, to be smeared onto slides for direct examination or cultured in a growth medium. This method is by far the gold standard for defining candidiasis diagnosis. However it is difficult to apply on sensitive patients and almost impossible on patients showing no clinical appearance of oral candidiasis. AIDS patients are very prone to candida infection and have a tendency of repetitive infection involving mixed species. As many candida species show different susceptibility to anti-fungal agents, it is necessary to identify the species causing the infection in the management of oral candidiasis. Oral rinse is a suggested method to obtain candida isolate to be cultured for further analysis such as species identification. This method is simple and less risky on infection transmission as less tools are required in the procedure. Purpose: This study aimed to assess the application of oral rinse as an alternative method to culture Candida isolate from AIDS patients. Methods: A cross-sectional observative study was conducted in HIV/AIDS in-Patient Facility of Intermediate Care Unit for Infection Disease, Dr. Soetomo Hospital Surabaya. Fourteen stadium 4 AIDS patients matching criteria were swabbed on 1/3-posterior of the tongue, and then given 10 ml phosphate buffer saline to rinse vigorously for 15 seconds. Both specimens were cultured on Sabouraud’s dextrose agar and colony growth was observed. Results: Candida colonies were able to grow from all 14 isolates (100%) by both methods. Qualitatively, cultures from oral rinse specimens were more populated than cultures from swab specimens. Conclusion: Oral rinse is an applicable technique to obtain Candida species isolate. This technique is safe, easy, non-invasive, and needs less tools therefore less risky for HIV transmission.Latar belakang: Isolat Candida mudah diambil dengan cara mengusap lesi candidiasis, baik untuk dioleskan pada kaca preparat untuk pemeriksaan langsung maupun dikultur. Hingga kini, metode tersebut dinyatakan sebagai “standar emas” untuk menentukan diagnosis. Namun kekurangan metode ini yaitu berisiko merangsang muntah pada pasien sensitif, dan hanya bisa dilakukan bila tampak jelas ada lesi. Candidiasis adalah penyakit nosokomial yang sering terjadi. Pasien AIDS sangat rentan terhadap infeksi oportunis ini secara rekuren dan persisten. Identifikasi spesies penyebab harus dilakukan karena berbagai spesies Candida memiliki kerentanan yang berbeda terhadap berbagai jenis antifungal. Oral rinse adalah metode pengambilan isolat Candida yang non-invasif. Isolat yang didapat bisa dikultur dan diidentifikasi, selain itu bisa dilakukan pada pasien yang belum menunjukkan adanya lesi candidiasis untuk menentukan besar risiko pasien terkena candidiasis, sehingga dapat ditentukan perlu tidaknya pemberian profilaksis antifungal. Tujuan: Penelitian ini bertujuan mengamati efektivitas metode oral rinse untuk mengisolasi Candida dari rongga mulut pasien AIDS. Metode: Penelitian observasional dilakukan di bagian Rawat Inap Unit Perawatan Intermediate Penyakit Infeksi RSUD Dr. Soetomo. Swab pada 1/3 posterior lidah dilakukan pada 14 pasien yang memenuhi kriteria, kemudia pasien diberi 10 ml phosphate buffer saline untuk berkumur kuat-kuat selama 15 detik. Spesimen yang didapat melalui kedua metode dikultur pada medium Sabouraud untuk diamati. Hasil: Koloni Candida berhasil dikultur dari 14 spesimen (100 %) melalui kedua metode isolasi. Secara kualitiatif tampak bahwa hasil kultur dari oral rinse tampak lebih subur. Kesimpulan: Oral rinse adalah metode yang dapat diaplikasikan untuk mengisolasi Candida dari rongga mulut pasien. Tekniknya mudah, aman, non-onvasif, dan tidak memerlukan peralatan dan ketrampilan khusus, sehingga mengurangi risiko transmisi HIV.
Acid fast bacilli detected in the oral swab sample of a pulmonary tuberculosis patient Bakti, Reiska Kumala; Mertaniasih, Ni Made; Ernawati, Diah Savitri; Soebadi, Bagus; Hadi, Priyo
Dental Journal (Majalah Kedokteran Gigi) Vol 51, No 2 (2018): June 2018
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v51.i2.p91-94

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Background: Tuberculosis (TB) is an infectious disease that persists as a health problem worldwide. Mycobacterium tuberculosis, as an etiological agent, is transmitted from infected to uninfected individuals via airborne droplet nuclei. Oral health care workers or dental practitioners may be at high risk of TB infection because of their close proximity to infected individuals during treatment procedures. Simple and rapid screening of mycobacterium tuberculosis in the oral cavity is necessary in order to prevent transmission of infection. Purpose: To investigate the presence of acid-fast bacilli in the buccal mucosa of pulmonary TB patients. Methods: Nineteen pulmonary TB patients of both sexes, ranging in age from 19 to 74 years old participated in this study. The diagnosis of tuberculosis was performed by clinical symptom assessment and supporting examination, including acid-fast bacilli on sputum examination. Two buccal mucosa swabs taken from pulmonary TB patients were collected for acid fast bacilli direct smear by Ziehl Neelsen staining. Results: With regard to mycobacterium tuberculosis, acid-fast bacilli presented in 10.5% of the oral buccal mucosa swabs of subjects, whereas in the sputum specimens, bacilli were found in 52.6% of subjects. Conclusion: Acid-fast bacilli can be found in the buccal epithelial mucosa of pulmonary tuberculosis patients, although its presence was very limited.
Rancang Bangun Sistem Pakar Untuk Menentukan Penyakit Mulut Dengan Menggunakan Metode Certainty Factor Ardiyanto, Meitha Tri; Irawan, Jusak; Soebadi, Bagus
Jurnal Sistem Informasi dan Komputerisasi Akuntansi (JSIKA) Vol 4, No 2 (2015)
Publisher : Jurnal Sistem Informasi dan Komputerisasi Akuntansi (JSIKA)

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Abstract

Dentistry graduates are required to treat patients with various diseases of mouth. A dentist who examined the patient should undertake a careful and thorough examination in order to determine the disease suffered by the patient. It is not always easy for the newly graduated dentists to deal with a wide variety of oral diseases. It is urgently needed a system that is able to facilitate the new dentist in diagnosing diseases of the mouth and how to follow up the disease. Based on the description of the  problems, in this work we designed a web-based expert system application. The application is expected to help to overcome the problems of dentists who just completed his studies in diagnosing and following up on the patient's natural disease. The expert system uses the certainty factor method to determine any symptoms experienced by the patient. The diagnosis is expected to produce a report to assist dentists in making a follow-up to the natural disease in the patient and save it into the database system. Based on the test results showed that the application of this expert system has the accuracy of 100% to indicate that the system is able to determine the type of oral disease. The accuracy of the results obtained from 10 test by a dentist.
RECCURENT TRAUMA-INDUCED APHTHOUS STOMATITIS IN ADJUSTMENT DISORDER PATIENTS Yuliana, Y.; Winias, Saka; Hendarti, Hening Tuti; Soebadi, Bagus
Dental Journal (Majalah Kedokteran Gigi) Vol 52, No 3 (2019): (September 2019)
Publisher : Faculty of Dental Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v52.i3.p163-167

Abstract

Background: Adjustment disorder is a temporary psychological condition related to emotional responses or behaviour in reaction to stress resulting from certain changes in a specific period of an individual?s life yet which does not significantly affect his/her daily life. Recurrent aphthous stomatitis (RAS) constitutes recurrent inflammation of the oral mucosa, in the form of an ulcer, frequently associated with psychological stress. Occasionally, a patient does not realise that she/he is suffering from a psychological disorder until the emergence of clinical symptoms, among them recurrent ulcers the causes of which are unknown. Purpose: This article presents a case of adjustment disorder diagnosed from symptoms observable in the oral cavity. Case: The case involved a 21-year-old student who presented with the symptoms of large, painful ulcers on her tongue, the inside of her cheek, and the floor of her mouth. These symptoms had been observable for one month but remained untreated. The patient only ate once a day or even once every two days. An introverted personality, she did not associate with other people. Case management: The procedure covered anamnesis, clinical examination, blood laboratory tests, total immunoglobulin E (IgE), an Antinuclear Antibody (ANA) test, bacterial and fungal culture in ulcus, questionnaire screening on psychological disorders, cortisol level examination and referral to a psychiatrist. Symptomatic therapy administered to the patient led to recovery of the ulcer in 29 days. Conclusion: RAS can be triggered by psychological stress which induces changes in the immune system and oral mucosa tissue.