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ANTIOXIDANT ACTIVITY OF METHANOL EXTRACTS FROM THE STEM BARK OF MANGROVE PLANT Rhizophora mucronata Mahmiah, Mahmiah; Giman, Giman; Aminah, Nanik Siti; Tanjung, Mulyadi
UNEJ e-Proceeding 2016: Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UNEJ e-Proceeding

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Abstract

Numbers of diseases such as stroke, diabetes, gout,and even cancer are caused by the reaction of freeradicals (oxidants) found in the body. Those diseasescurrently have not yet controlled. Deleteriouslifestyle, lack of exercise, or genetics can be thetrigger to this oxidant. Based on Chemotaxonomic,drugs that have been used to inhibit the oxidationprocess or termination stage of free radicals containthe active ingredient in the form of secondarymetabolites of alkaloids, phenolics, terpenoids andsteroids. For example, phenolic compounds such asflavonoids, xanthones, antioxidants and polyphenolsis a good agent because it has a structure with a highdegree of oxidation (Suares, et al, 2010).Researches related to the exploration of antioxidantactive ingredient has been more focused onsecondary metabolites found in terrestrial plants.The development of natural compounds potential ofmarine plant material such as mangrove are still notreceived much attention. Spalding et al. in 2001explained that mangroves plant in Indonesia is thehighest in the world, both in terms of quantity area(± 42 550 km2) as well as the number of species (±45 species). This basic natural resource of Indonesiamangrove is certainly valuable promisingopportunities to be expanded as a biological drug.Mangroves plant that commonly used as medicinediscovered from various species i.e: Acanthusilicifolius, Avicennia alba, Avicennia marina,Avicennia offinalis, Bruguiera cylindrical, Bruguieraexaristata, Bruguiera gymnorrhiza, Ceriops tagal,Hisbiscus tiliaceus, Ipomoea pes-capre, Lumnitzeraracemosa, Nypa fructicans, Pluchea indicaRhizophora apiculata, Rhizophora mucronata andSonneratia alba. Those plants are usually utilized asantiasma, antidiuretic, antidiabetic, reliever itching,and others. (Purnobasuki, 2004).The potential of mangroves as a drug is veryimportant to be developed considering the need fordrugs is increasing deals with the growing ofpopulation and many kinds of diseases such ascancer, hypertension, tumor diseases and diseasescaused by chemical or biological waste pollutionfrom viruses and bacteria. People are more likely tochoose drugs that are natural because relatively takefew side effects or even none at all.Several studies of mangrove plants from genusRhizophora that have antioxidant bioactivity areshown in the crude butanol extract of mangrove R.apiculata with IC50 33.34 pg / mL (Gao, 2012). Themethanol extract of R. mangle’s stem were alsodocumented to have antioxidant activity (Palacio, etal, 2014).One of mangroves found in Surabaya East Coastal(Pamurbaya), East Java, Indonesia is the mangroveRhizophora mucronata. This mangrove species isindigenous mangroves that ethno-botanicallypopular used as a pain reliever and dyes naturalwood. Secondary metabolites contained in theleaves, bark, stems, roots, and fruit are different inquantity. The content of secondary metabolites inplant commonly used as a medicine is from generalpart of the bark. Therefore, on the basis ofchemotaxonomic and ethno-botany of mangroves R.mucronata, this study aims to explore the bioactivityof antioxidant from the stem bark of R. mucronata.
THREE PRENYLATED FLAVONOIDS FROM MACARANGA PEARSONII MERR. Marliana, Eva; Tjahjandarie, Tjitjik Sri; Tanjung, Mulyadi
PROSIDING SEMINAR KIMIA PROCEEDING OF INTERNATIONAL CONFERENCE 2015
Publisher : PROSIDING SEMINAR KIMIA

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Abstract

Three prenylated flavonoids, 4’-O-methyl-8-isoprenyleriodictiol (1), 4’-O-methyl-8-isoprenylnaringenin (2) and lonchocarpol A (3) have been isolated from the leaves of Macaranga pearsonii Merr.. The structure of compounds have been elucidated based on its spectroscopic data, including UV, 1D and 2D NMR, and HREISMS spectra.
Aktivitas Antimalaria Senyawa Flavanon Terisoprenilasi Dari Kulit Batang Erythrina fusca L Fatmawati, Novi; Anggreini, Novi; Saputri, Ratih Dewi; Tjahjandarie, Tjitjik Srie; Tanjung, Mulyadi
Jurnal Pharmascience Vol 5, No 1 (2018): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20600/jps.v5i1.5786

Abstract

ABSTRAK Dua senyawa flavanon terisoprenilasi yakni lonkokarpol A (1) dan lupinifolin (2) telah diisolasi dari kulit batang Erythrina fusca L. Struktur senyawa flavanon terisoprenilasi ditetapkan berdasarkan analisis spektroskopi UV, IR, MS dan NMR. Uji aktivitas antimalarial senyawa 1–2 terhadap Plasmodium falciparum strain 3D7 memperlihatkan IC50 1,18 dan 0,82 µg/ml yang dikategorikan sangat aktif. Kata kunci : Erythrina fusca L., lonkokarpol A, lupinifolin, antimalaria ABSTRACT Two isoprenylated flavanones namely as lonchocarpol A (1) dan lupinifolin (2) were isolated from the stem bark of Limonia accidissima L. Erythrina fusca L. Their structures were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their antimalarial against Plasmodium falciparum strain 3D7 showing their IC50 were 1.18 and 0.8 µg/ml, respectively and very high activity. Keywords : Erythrina fusca L., lonchocarpol A, lupinifolin, antimalarial
AKTIVITAS ANTIOKSIDAN SENYAWA KUMARIN TER-O-GERANILASI DARI AKAR Limonia acidissima L. Tjahjandarie, Tjitjik Srie; Saputri, Ratih Dewi; Tanjung, Mulyadi
Journal of Tropical Pharmacy and Chemistry Vol 4 No 2 (2017): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (498.906 KB) | DOI: 10.25026/jtpc.v4i2.143

Abstract

Five O-geranylated coumarins namely as auraptene (1), 7-((2’E,6’E)-5’-hydroxy-3’,7’-dimethylocta-2’,6’-dienyloxy)coumarin (2), 7-(2’E,5’E)-7’-hydroxy-3’,7’-dimethylocta-2’,5’-dienyloxy) coumarin (3), 6-methoxy-7-oxygeranylcoumarin (4), and 8-oxygeranylpsoralen (5) were isolated from  the roots of Limonia accidissima L.  Their structures were determined  based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–5 were evaluated for their radical scavenging against 2,2-diphenyl-1-picrylhydrazyl (DPPH), showing their IC50 were 462; 13; 260; 210 and 234 µg/ml, respectively. Keywords: Limonia accidissima L.,  O-geranylated coumarins, antioxidant activity, DPPH
ISOLASI SENYAWA ALKALOID TURUNAN FUROKUINOLIN DARI RANTING Toddalia asiatica L. DAN UJI AKTIVITAS ANTIKANKER Tanjung, Mulyadi; Rahayu, Devina Oktari; Tjahjandarie, Tjitjik Srie
Jurnal Kimia Riset Vol 3, No 2 (2018): Desember
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (536.999 KB) | DOI: 10.20473/jkr.v3i2.12062

Abstract

AbstrakToddalia asiatica merupakan tumbuhan perdu yang tersebar di Afrika, Asia, Madagascar, dan Australia (Hu et al., 2015). Senyawa metabolit sekunder yang ditemukan tumbuhan Toddalia asiatica L. adalah alkaloid. Ekstraksi senyawa alkaloid dari tumbuhan Toddalia asiatica L. dengan cara maserasi menggunakan pelarut metanol pada suhu kamar. Proses isolasi dilakukan melalui fraksinasi dan pemurnian menggunakan kromatografi kolom gravitasi, dan kromatografi radial. Hasil isolasi yang didapatkan merupakan senyawa alkaloid turunan furokuinolin yaitu skimmianin. Struktur senyawa alkaloid turunan furokuinolin yang  diketahui melalui analisa hasil spektroskopi UV, IR, 1D NMR (1H-NMR dan 13C-NMR),  serta 2D NMR (HMBC dan HMQC) dan uji aktivitas antikanker terhadap sel kanker murin leukemia P-388. Kata kunci : Alkaloid turunan furokuinolin, skimmianin, Toddalia asiatica L., antikanker AbstractToddalia asiatica L. is a bushy plant that spreads in Africa, Asia, Madagascar, and Australia (Hu et al., 2015). The secondary metabolite compound found in Toddalia asiatica L. is alkaloid. Extraction of alkaloid compounds from Toddalia asiatica L. by maceration using methanol at room temperature. The isolation process is diluted by fractionation and purification using column chromatography of gravity and radial chromatography. The result  of isolation is an alkaloid compound derived furokuinolin, skimmianin. The structure of alkaloid compounds derived from furokuinolin known through spectroscopic analysis including UV, IR, 1D NMR (1H-NMR and 13C-NMR), and 2D NMR (HMBC and HMQC) and the anticancer activity test against the cancer cells murine P-388.Key word :    Alkaloid  compound  derived  furokuinolin,  skimmianin,  Toddalia asiatica L., anticancer
AKTIVITAS ANTIKANKER SENYAWA STILBENOID DARI DAUN Macaranga aleuritoides Aldin, Muhammad Fajar; Saputri, Ratih Dewi; Tjahjandarie, Tjitjik Srie; Tanjung, Mulyadi
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol 2, No 1 (2019): Jurnal Farmasi Medica
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.2.1.2019.23606

Abstract

AKTIVITAS ANTIKANKER SENYAWA STILBENOID DARI DAUN Macaranga aleuritoides  Muhammad Fajar Aldin1), Ratih Dewi Saputri1), Tjitjik Srie Tjahjandarie1), Mulyadi Tanjung1*)1)Kimia Organik Bahan Alam, Departemen Kimia, Fakultas Sains dan Teknologi, Universitas Airlangga, Surabayamulyadi-t@fst.unair.ac.id ABSTRACT            Macaranga aleuritoides is one of species belongs to Euphorbiaceae family. Macapruinosin A (1) is one stilben derivatives with an irregular sesuiterpenyl side chain was isolated from the leaves of Macaranga aleuritoides. The structure of the isolated compound were determined by spectroscopic methods, including UV, IR, 1D and 2D NMR. The anticancer activity of macapruinosin A towards murin P-388 cells showed IC50 value of 1.65 μg/mL and showed high activity.Keywords : Macaranga aleuritoides, macapruinosin A, stilbenoid, anticancer. ABSTRAK            Macaranga aleuritoides merupakan salah satu spesies tumbuhan dari famili Euphorbiaceae. Makapruinosin A, senyawa turunan stilben dengan rantai samping seskuiterpen tak teratur telah diisolasi dari daun M. aleuritoides Struktur senyawa tersebut ditetapkan berdasarkan analisis spektroskopi,meliputi UV, IR, 1D dan 2D NMR. Uji aktivitas antikanker senyawa makapruinosin A terhadap sel murin P-388 memperlihatkan nilai IC50 sebesar 1,65 μg/mL dan dikategorikan sangat aktif. Kata kunci : Macaranga aleuritoides, makapruinosin A, stilbenoid, antikanker.     
AKTIVITAS ANTIOKSIDAN SENYAWA FLAVONOID DARI Macaranga pearsonii Merr. Marliana, Eva; Tjahjandarie, Tjitjik Srie; Tanjung, Mulyadi
JURNAL KIMIA MULAWARMAN Vol 13 No 2 (2016)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract

Tiga senyawa flavanon , 4’-O-metil-8-isoprenileriodiktiol (1), 4’-O-metil-8-isoprenilnaringenin (2) and Lonkokarpol A (3) , telah diisolasi dari ekstrak metanol daun Macaranga pearsonii Merr. Elusidasi struktur senyawa berdasarkan data spektroskopi UV, 1D and 2D NMR, and HREISMS. Senyawa 1 – 3 ditentukan aktivitas antioksidannya terhadap peredaman radikal bebas 2,2-diphenyl-1-picrylhydrazyl (DPPH), dengan nilai IC50 adalah 536,89 μM, 1226,11 μM dan 426,43 μM.
DUA ISOMER SENYAWA FLAVONOID DARI BATANG SESBANIA GRANDIFLORA Tjahjandarie, Tjitjik Srie; Saputri, Ratih Dewi; Putri, Nathasa Aquila; Dewi, Bella Kurniawati; Tanjung, Mulyadi
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol 3, No 1 (2020)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.3.1.2020.28962

Abstract

ABSTRACTTwo isomer flavonoids, 7,4´-dihydroxyflavanon (1) and 7,4´-dihydroxyisoflavanon (2) were isolatedfrom the bark of Sesbania grandiflora L. Their structures were determined based on spectroscopicdata such as UV, IR, MS, 1D and 2D NMR.Keywords : Sesbania grandiflora L., flavonoid, 7,4´-dihydroxyflavanon, 7,4´-dihydroxyisoflavanonABSTRAKDua isomer senyawa flavonoid, 7,4´-dihidroksiflavanon (1) dan 7,4´-dihidroksiisoflavanon(2) telah berhasil dipisahkan dari batang Sesbania grandiflora L. Kedua struktur senyawaisomer ditetapkan berdasarkan analisis spektroskopi UV, IR, MS, 1D dan 2D NMR.Kata kunci : Sesbania grandiflora L., flavonoid, 7,4´-dihidroksiflavanon, 7,4´-dihidroksiisoflavanon
KUMARIN TERISOPRENILASI DAN ALKALOID INDOL DARI KULIT BATANG Zanthoxylum ovalifolium TUTCHER Tanjung, Mulyadi
JURNAL KIMIA MULAWARMAN Vol 15 No 2 (2018)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v15i2.587

Abstract

Two isoprenylated coumarins, imperatorin (1), isopimpinelin (2) and one indol alkaloid compound, canthine-6-one (3) were isolated from the stem bark of Zanthoxylum ovalifolium Tutcher. Their structures were determined based on spectroscopic data such as UV, IR, MS and NMR. Imperatorin (1) showed high activity toward DPPH radical and isopimpinelin (2) and chantine-6-one (3) has moderate activity.
Flavanon Fatmawati, Novi; Anggreini, Novi; Saputri, Ratih Dewi; Tjahjandarie, Tjitjik Srie; Tanjung, Mulyadi
JURNAL KIMIA MULAWARMAN Vol 16 No 1 (2018)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v16i1.586

Abstract

Two isoprenylated flavanones namely as lonchocarpol A (1) dan lupinifolin (2) were isolated from the stem bark of Limonia accidissima L. Erythrina fusca L. Their structures were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their antimalarial against Plasmodium falciparum strain 3D7 showing their IC50 were 1.18 and 0.8 µg/ml, respectively and very high activity.