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The effect of lecithin on liver function of white rats (Rattus norvegicus) induced carbon tetrachloride Dewi, Lestari
Biomedical Engineering Vol 2, No 1 (2016)
Publisher : Biomedical Engineering

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (572.359 KB)

Abstract

Objective: To prove that the lecithin is administered orally has hepatoprotective effect on white male rats given CCl4 intraperitoneally.Material and Methods: 45 male Wistar rats, aged 12 weeks were randomly divided into five groups. Group I, given solvent CMC - Na 0.25% dose of 0.01 ml/g bw, and were given olive oil dose of 1 ml/kg bw, intraperitoneal injection. Group II, given solvent CMC - Na 0.25% dose of 0.01 ml/g bw, and given CCl4 dose of 1 ml/kg bw,dissolved in olive oil by intraperitoneal injection. Group III, IV and V respectively given dose lecithin 90/180/360 mg/ kg bw,dissolved with 0.25% CMC-Na, and  given CCl4 dose of 1 ml/kg bw dissolved in olive oil at a ratio of 1: 1, by intraperitoneal injection. On day 10, 24 hours after administration of CCl4 and olive oil , all the rats dissected, after first anesthetized with ether by inhalation. Then the blood taken from the heart to examine the level of AST and ALT in serum and hepar were taken for  histopathological examination.Results: Giving  lecithin 90/180/360 mg/kg bw were accompanied CCl4 1 ml / kg body weight (group III, IV, and V), shown to reduce levels of SGOT in serum compared with the group that received only CCl4 and giving lecithin 90/180/360 mg/ kg bw with CCl4 1 ml/kg bw  (group III, IV, and V) is proven to reduce ALT levels compared with the group that received only CCl4. On histopathological examination of liver cells proves that lecithin dose 90 / 180/360 mg/kg bw with CCl4 1 ml/kg bw is proven to reduce the amount of cell necrosis than the group that only received CCl4.Conclusion: Lecithin has a protective effect against the liver function.
Hubungan Tekanan Darah dengan Volume Pendarahan Intraserebral pada Pasien Stroke Hemoragik di Ruang Rawat Inap Saraf Rumkital Dr Ramelan Surabaya YULIAN, KENNY; ADAM, OLIVIA MAHARDANI; DEWI, LESTARI
Hang Tuah Medical journal Vol 16, No 2 (2019)
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (373.446 KB) | DOI: 10.30649/htmj.v16i2.176

Abstract

ABSTRACTBackground. Hemorrhagic stroke is a spontaneous bleeding in the brain that is usually life threatening. The most common risk factor of hemorrhagic stroke is hypertension. Hypertension can cause change in the structure of the artery wall which can cause the blood vessels near the brain to rupture easily. Purpose. To analyze the correlation between blood pressure and intracerebral haemorrhage volume in hemorrhagic stroke patients in Dr. Ramelan Navy Hospital neurologic ward.  Method. This research is using a cross sectional study design. This study is done using primary data collection, using the head CT Scan result to measure the patient’s intracerebral hemorrhage volume and patient’s ER admission data for the blood pressure. Results. The study is performed to 26 haemorrhagic stroke patients who fits the inclusion and exclusion criteria. Correlation test shows no correlation between blood pressure and intracerebral haemorrhage volume in haemorrhagic stroke patients in Dr. Ramelan Navy Hospital neurologic ward, with significance (p) value of 0.888 > α (0.05). Conclusion. There is no correlation between blood pressure and intracerebral haemorrhage volume in haemorrhagic stroke patients in Dr. Ramelan Navy Hospital neurologic ward.Keywords: Blood Pressure, Intracerebral Haemorrhage Volume, Haemorrhagic Stroke ABSTRAKLatar belakang. Stroke hemoragik adalah pendarahan otak spontan yang seringkali mengancam jiwa. Faktor resiko utama terjadinya stroke hemoragik adalah adanya hipertensi. Hipertensi dapat menyebabkan perubahan struktur dinding arteri sehingga pembuluh darah didekat otak mudah ruptur. Tujuan penelitian. Mengetahui hubungan antara tekanan darah dengan volume pendarahan intraserebral pada pasien stroke hemoragik di ruang rawat inap saraf RUMKITAL Dr. Ramelan Surabaya. Metode penelitian. Penelitian ini adalah penelitian dengan desain cross sectional study. Penelitian ini dilakukan dengan perolehan data primer, yaitu berupa hasil CT scan kepala untuk mengetahui volume pendarahan intraserebral pasien dan data pasien saat masuk IGD untuk tekanan darah pasien. Hasil. Penelitian dilakukan pada 26 pasien stroke hemoragik yang masuk kriteria inklusi dan eksklusi. Hasil uji korelasi menunjukkan tidak ada hubungan antara tekanan darah dengan volume pendarahan intraserebral pada pasien stroke hemoragik di ruang rawat inap saraf RUMKITAL Dr. Ramelan Surabaya, dengan nilai signifikansi (p) = 0.888 > α (0.05). Kesimpulan. Tidak ada hubungan antara tekanan darah dengan volume pendarahan intraserebral pada pasien stroke hemoragik di ruang rawat inap saraf RUMKITAL Dr. Ramelan Surabaya.Kata Kunci : Tekanan Darah, Volume Pendarahan Intraserebral, Stroke Hemoragik