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Effects of zinc supplementation on nutritional status and cognition in children S, Retno Asih; Warsiki, Endang; Hidajat, Boerhan
Paediatrica Indonesiana Vol 46 No 2 (2006): March 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi46.2.2006.64-70


Background Zinc deficiency is common in children in develop-ing countries and data suggests the effects are detrimental towardschildren’s growth and neuropsychologic performance. Results ofmultiple studies which assess these effects have been inconsis-tent.Objective To evaluate the effects of zinc supplementation onnutritional status and cognition in children with zinc deficiency.Methods Forty-six stunted children aged 50-80 months with lowhair zinc levels were randomly assigned to receive either 7.5 mgelemental Zn or placebo twice a week for 3 months. Anthropom-etry and cognition were assessed at the beginning and the end ofthe supplementation period. Differences among both groups foranthropometry and cognition before and after supplementation wereanalyzed with paired t-test. A comparison of different anthropom-etry and cognition among the two groups were analyzed using theindependent t-test.Results There were no significant differences among baselinecharacteristics except on sex distribution.There was a significantdifference in weight for age between the zinc group and placebo[0.28 (SB 0.18) vs 0.09 (SB 0.14); P=0.0001]. Height incrementswere also greater in the zinc group [0.34 (SB 0.15) vs 0.02 (SB0.12); P=0.0001). There was no significant difference betweenweight for height. Intelligence quotient (IQ) measured by theStanford-Binnet test was slightly higher in the zinc group [2.26 (SB3.11) vs 2.00 (SB 2.81], but the difference was not significant ac-cording to sex.Conclusion Zinc supplementation produced highly positive re-sponses in weight for age and height for age increments in chil-dren with zinc deficiency compared with placebo. There was noeffect of zinc supplementation on weight for height index and noneon cognition measured by intelligence quotient (IQ)
Empirical Antibiotic Therapy Assessment of Patients diagnosed with Sepsis in Intermediate Care Ward of Internal Medicine Department of Dr. Soetomo General Hospital according to Gyssens Method Adiwinoto, Ronald Pratama; Sustini, Florentina; Hardiono, Hardiono; Widodo, Agung Dwi Wahyu; Hidajat, Boerhan; Hadi, Usman
Oceana Biomedicina Journal Vol 1, No 2 (2018): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (546.601 KB) | DOI: 10.30649/obj.v1i2.17


Rational empirical antimicrobial therapy is an important component of sepsis patient management. This study aimed to assess the rationality of empirical antimicrobial therapy in patients diagnosed with sepsis admitted in intermediate care ward of internal medicine department (RPI) of Dr. Soetomo General Hospital from January 2016 to July 2017. Medical records of 91 patients diagnosed with sepsis were collected and studied retrospectively in period from July 2017 to November 2017. 91 (85.05%) medical records from 107 sepsis patients were evaluated. Cultures and antimicrobial sensitivity tests were carried out in 21 (23.07%) patients. 14 patients yielded positive culture results, 9 of which were MDRO positive with ESBL as resistant marker. Empirical antibiotic therapies for these patients were reviewed according to Gyssens method.73 (80.2%) of 91 patients were deemed receiving appropriate empirical antibiotic therapies. Ceftriaxone IV injection as monotherapy or combination therapy were the most common empirical antibiotic therapies (82 in 91 patients, 90.1%), despite local microbiologic flora and antibiogram show most pathogens were resistant to ceftriaxone. Mortality rate in this study was high, 92.3% (84 patients died) despite rational empirical antibiotic therapies were high. This study concluded that empirical antibiotic therapies in sepsis patients according to guidelines adopted in Soetomo General Hospital, albeit deemed rational, was no longer appropriate according to local antibiogram issued by microbiological department of Soetomo General Hospital. Keywords: Empirical Antibiotics Therapy, Gyssens criteria, Intermediate Care Ward, Sepsis, Septic Shock