International Journal of Nasopharyngeal Carcinoma
Vol 1 No 01 (2019): International Journal of Nasopharyngeal Carcinoma

ASSOCIATION OF E-CADHERIN EXPRESSION TO CLINICAL STAGE OF NASOPHARYNGEAL CARCINOMA

Triastuti, Felicia Melani (Unknown)
Asnir, Rizalina A. (Unknown)
Yudhistira, Ashri (Unknown)
Eliandy, Sutoyo (Unknown)



Article Info

Publish Date
23 May 2019

Abstract

Background: Nasopharyngeal carcinoma (NPC) has a high incidence rate in southern China and Southeast Asia and a high rate of metastasis in head and neck cancer. NPC is a squamous cell carcinoma that grows from the surface of the lateral wall of the nasopharynx. E-cadherin is known as a tumor suppressor protein and the loss of this expression in tumor cells is related to epithelial-mesenchymal transition that occurs during tumor development and metastasis. Objective:To determine the relationship between E-cadherin expression and clinical stage in patients with nasopharyngeal carcinoma. Methods: An analytical study with a cross-sectional study design, the number of samples was 30 patients with NPC who underwent immunohistochemical examination on KNF paraffin block. Result: Overexpression of E-cadherin was found in T1 and T2 of 15 subjects (100%). The overexpression of E-cadherin was found in lymph node N2 and N3 of 19 subjects (95%). The overexpression of E-cadherin was found in the histopathological type of Non-Keratinizing Squamous Cell Carcinoma of 24 subjects (96%). The overexpression of E-cadherin was found at an advanced stage of 26 subjects (100%). Conclusion: No significant association was found between E-cadherin expression and tumor size (p = 1,000), lymph node metastasis (p = 1,000), histopathological type (p = 1,000) and tumor stage (p = 0.133).

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Journal Info

Abbrev

IJNPC

Publisher

Subject

Health Professions Medicine & Pharmacology

Description

The International Journal of Nasopharyngeal Carcinoma (IJNPC) is an open access journal that publishes research findings from disciplines related to nasopharyngeal carcinoma. This journal was published by the Center of Excellence Nasopharyngeal Carcinoma Universitas Sumatera Utara, collaborated with ...