Objective: Thalasemia is an inherited blood diseases cause which abnormalities systemically and intraorally. This case report to discuss management of Aphthous-Like Ulcer in 24 year old man with Thalasemia ? Intermedia and need blood transfusion every month. Ulcer occured 2 days before transfusion.Methods: Based on history, clinical examination, hematologi and ferritin tests.Results: The diagnosis was Aphthous Like ulcer induce by trauma. Patient was treated using anti-inflammatory mouthwash and recovery was achieved within 3 weeks follow-up. Conclusion: Management of oral manifestation in Thalasemia patient need multidiciplinary approach to obtain successful therapy.
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