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PHARMACIANA
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Medicine & Pharmacology

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Articles 529 Documents

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STUDI KAPASITAS ADSORPSI-REDUKSI ION Au(III) PADA ASAM HUMAT HASIL ISOLASI DARI TANAH GAMBUT RAWA PENING Prasasti, Dian; Juari, Sri; Sudiono, Sri
Pharmaciana Vol 2, No 2 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Isolation of peat soil humic acid and its application for adsorption-reduction ofAu(III) have been conducted. Humic acid was isolated from peat soil that was collectedfrom Rawa Pening, Central Java. Isolation of humic acid from peat soil was based onconventional alkaline extraction. Humic acid was extracted from peat soil with NaOH0.1 M, then precipitated with 0.1 M HCl, and purified with 0.1 M HCl/0.3 M HF 1/1.The isolated humic acid was characterized by FTIR spectroscopy, then applied foradsorption reduction of Au(III). Isothermic adsorption capacity on adsorptionreduction process of Au (III) also were studied. The gold metal formed was confirmedby XRD diffractogram, and photo optical microscope. The adsorption capacity withLangmuir isothermic model for humic acid was 192 mg/g. Peaks of gold particles in thedifractogram are 2 = 38, 44, and 64.

EFEK HEPATOPROTEKTIF SERBUK AKAR PASAK BUMI (Eurycoma longifolia Jack.) DILIHAT DARI AKTIVITAS SGPTSGOT TIKUS JANTAN YANG DIINDUKSI CCl4 Adikusuma, Wirawan; Bachri, Moch. Saiful
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

This study was designed to evaluate the hepatoprotective effect of the powder Eurycomalongifolia Jack. From the activity level of SGPT-SGOT on CCl4-induced in male rats. Twentyfive male rats (150-250 g) divide in to 5 groups. Group I treated with aquadest was kept asnormal, group II treated with a single dose of CCl4 (1 ml/ kg BW i.p), group III and IV weretreated with Eurycoma longifolia Jack. (100 mg/kg BW and 200 mg/kg BW p.o) respectivelyand CCl4 (1 ml/kg BW i.p), group V treated with a single dose of curcumin (100 mg/kg BWp.o) and CCl4 (1 ml/kg BW i.p). Blood was collected from vena porta for determination ofSGPT-SGOT. The study showed the activity level of SGPT from the rats was treated byEurycoma longifolia Jack. 100 mg/kg BW and 200 mg/kg BW, Curcumin, and control groupsare 150.0Â±5.099 U/L; 113.6Â±5.508 U/L; 60.5Â±2.887 U/L; and 129.0Â±6.055 U/L respectively. Mean while the activity level of SGOT from the rats was treated by Eurycoma longifolia Jack.100 mg/ kg BW and 200 mg/ kg BW, Curcumin, and control groups are 369.4Â±11.165;263.0Â±1.803; 194.5Â±7.448; and 451.5Â±16.759 U/L respectively. The Eurycoma longifoliaJack. powder and Curcumin significantly (p < 0.05) declines two enzymes (SGPT and SGOT)than control group. The results concluded that Eurycoma longifolia Jack. powder hashepatoprotective effect.

The effects of croscarmellose sodium concentration on the physicochemical characteristics of orodispersible tablets of atenolol Parfati, Nani; Rani, Karina Citra
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Hypertension is the most common cardiovascular diseases suffered by geriatric patients. Their physiological changes make the administration of conventional tablets less effective, especially regarding compliance. One approach to overcome this problem is the development of orodispersible tablets, which soften easily and disintegrate quickly in the oral cavity. Atenolol is a class of Î²-blocker functioning as an anti-hypertensive drug that has been extensively used in hypertension therapy, and it has the potential to being developed as orodispersible tablets. A faster disintegration of orodispersible tablets will facilitate an earlier onset of dissolution. The addition of superdisintegrants can reduce the disintegration time of these tablets. Croscarmellose sodium is a superdisintegrant that can decrease the disintegration time to less than three minutes. This study aimed to optimize the formula of orodispersible tablets of atenolol using different concentrations of croscarmellose sodium, namely 10% (formula 1) and 20% (formula 2). The physicochemical characteristics of the tablets were evaluated to determine the best formula. The evaluation included a comparison to the control formula (0% of croscarmellose sodium). The results showed that formula 1 (10% of croscarmellose sodium) produced orodispersible tablets with the best physicochemical characteristics regarding tablet hardness, friability, in vitro dispersion time, and disintegration time. Formula 1 (%Q30 minutes= 98.31%) also met the standard of the dissolution of atenolol tablets set by the Farmakope Indonesia, i.e., the percent of dissolved drug in 30 minutes has to be higher than 85%. The drug dissolution efficiency of formula 1 was twice higher than that of the control formula.

OPTIMASI KOMPOSISI TEPUNG BERAS DAN FRAKSI ETANOL DAUN SENDOK (Plantago major, L) DALAM FORMULASI TABIR SURYA DENGAN METODE SIMPLEX LATTICE DESIGN Sugihartini, Nining
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Octyl methoxycinnamate is an active ingredient in sunscreen that will bedegradated after exposure by sunlight. On the other hand, antioxidants have potentialcapability as photoprotector which in this study is used the ethanol fraction of leaf ofPlantago major, L to support activity of OMS. In addition, rice flour is added toobecause it has the ability to reflect sunlight. The aim of this study is to obtain theoptimum composition of them, based on the effectivity of OMS. This study used threeformulas based on the simplex lattice design method with a comparison of octylmethoxycinnamate and rice flour as follows: FI (100%: 0%), the formula II (50%:50%), formula III (0%: 100%). All formulas were exposured by sunlight for 5 hours (at09:00 to 14:00 GMT) and in interval one hour samples were taken to measure the valueof % erythema transmission (% Te) and pigmentation (% Tp). Data were analysed toget the optimum composition which has the highest of response. The results showed that100% rice flour was the optimum addition to support activity of OMS as sunscreen withdecreasing of % erythema transmission and pigmentation was 200%, 75%,respectively.

The determination of metal content, microbial contamination and dissolution assessment of the ethanol extract of pasak bumi root Nurani, Laela Hayu; Kumalasari, Eka; Zainab, Zainab; Mursyidi, Achmad; Widyarini, Sitarina; Rohman, Abdul
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Â The Eurycoma longifoliais bitter therefore, to address this problem, it is prepared in a capsule form. The capsule dosage form Â must has Â the parameters of good quality, thus expected to increase the potential use of biodiversity and the interest of the community in consuming the medicine from the natural materials. The purpose of this research is to get the capsule product of ethanol extract of the Eurycoma longifolia root of quality through the test of total plate value and yeast yeast contamination, the determination of the metal content of Pb, Hg, Cd and the level of flavonoids released in the capsule dissolution test of ethanol extract Eurycoma longifolia root. The result of this research shows that the dissolution efficiency (DE120) capability of ethanol extract of Eurycoma longifolia root is 81,04Â±2,38%. Test of heavy metal content in capsule of Â of ethanol extract of Eurycoma longifolia root found level of Pb equal to 4,132 ppm and not detected content of Cd and Hg in capsule. This indicates that the capsule meets the requirements set by BPOM RI. Tests for total plate numbers (ALT) and yeast capsule ethanol extract of the E. longifolia root were each obtained data of 70 x 102 colonies / g and 4 x 102 colonies / g. It also shows that the capsules meet the requirements by BPOM RI.

Uji sifat fisik repelan minyak atsiri kombinasi rimpang temulawak dan rimpang jahe basis cold cream fatima, fatma; Widyaningsih, Wahyu; Ikhsanudin, Azis
Pharmaciana Vol 7, No 1 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Rimpang jahe (Zingiber officinale Roxb. Rhizome) dan rimpang temulawak (Curcuma xanthorrhiza roxb. Rhizome) memiliki kandungan minyak atsiri yang dapat berfungsi sebagai repelan. Guna mengatasi mahalnya rimpang jahe dan sifat iritatif minyak atsiri rimpang jahe, maka dikombinasikan dengan minyak atsiri rimpang temulawak. Basis cold cream memiliki fase minyak yang lebih banyak yang dapat meningkatkan kemampuan pengikatan minyak atsiri. Adanya basis tersebut diharapkan dapat meningkatkan efek repelan. Oleh karenanya, terkait efek repelan perlu dilakukan uji sifat fisik minyak atsiri untuk memastikan kemurnian dan mutunya, kemudian sebelum dilakukan uji efek repelan, perlu dilakukan uji sifat fisik sediaan repelan untuk memperoleh formula terbaik, yaitu formula yang dapat dioleskan dengan mudah dan nyaman jika digunakan.Â Â Â Â Â Â Â Â Â Â Â Minyak atsiri rimpang temulawak dan rimpang jahe diisolasi dengan metode destilasi uap dan air dan diuji sifat fisiknya, yang terdiri dari uji organolepstis, indeks bias dan berat jenis. Repelan dibuat dalam berbagai konsentrasi 2% v/b, 5% v/b, 10% v/b, 15% v/b, 20% v/b, dan 25% v/b, kemudian dilakukan uji daya sebar, daya lekat, dan viskositasÂ Â Â Â Â Â Â Â Â Â Â Berdasar hasil uji sifat fisik, minyak atsiri rimpang temulawak dan minyak atisri rimpang jahe telah terbukti kemurniannya. Semakin besar konsentrasi miyak atsiri kombinasi rimpang temulawak dan rimpang jahe pada sediaan repelan dengan basis cold cream, semakin kecil viskositasnya, sehingga daya lekat semakin kecil namun daya sebar semakin besar. Berdasar hasil tersebut, konsentrasi 25% Â b/v s(konsentrasi terbesar) adalah sediaan repelan yang paling baik karena paling lunak sehingga mudah diambil, dioleskan karena konsistensinya tidak keras dan paling mudah untuk dibersihkan dengan air

Potensi ekstrak etanol 70% akar saluang balum (Lavanga sarmentosa blume kurz) terhadap kualitas dan viabilitas sperma mencit Syarif, Yaumi Musfirah; Bachri, Moch Saiful; Nurani, Laela Hayu
Pharmaciana Vol 6, No 2 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The present study tried to investigate potency of L. sarmentosa root extract on quality and viability of mice sperm.This study used 25 Swiss male mice were randomly divided into five experimental groups of 5. The ethanolic extract of L. Sarmentosa (100, 200, 400 mg/kg b.w/days), control and X-gra were administered orally for 14 days. The animals were evaluated for sperma quality (sperm count and sperm motility) and viability at 14 days treatment. The results showed that administration of L.sarmentosa roots extract significantly increasing the sperm count (970x106cell/mL) at 400 mg/kg b.w/days (P 0.0040). The extract dose of 200 mg/Kg b.w and 400 mg/Kg b.w had the highest motility values (95%). Viability of sperm are 83.8%; 96.0%; 87.8% respectively at a dose of 100 mg/kg b.w, 200 mg/kg b.w and 400 mg/kg b.w. Present finding oral administration ofÂ L. sarmentosa roots extract has a potency of the quality and viability of mice sperm.

ISOLASI DAN UJI PENANGKAPAN RADIKAL BEBAS DPPH OLEH ISOLAT-1, FRAKSI ETIL ASETAT, DAN EKSTRAK ETANOL AKAR PASAK BUMI (Eurycoma longifolia Jack) Nurani, Laela Hayu
Pharmaciana Vol 3, No 1 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The free radical was produced when undertaking processes metabolit or opposedinfection and when the body dissolved food. The unstable free radical could beneutralised with antioxidant. The root of the pasak bumi (Eurycoma longifolia Jack)was known contained the compound flavonoid, that it was known had the activity asantioxidant. This research aimed at knowing the activity capacity of the capture of thefree radical the water fraction and the faction ethyl acetate fraction the extract ethanolof the root of the pasak bumi by using the DPPH method.The root of the pasak bumi was extracted with ethanol 70% used maceration. Theethanolic extract was dissolved in ethyl acetate, fractination with ethyl acetate so as tobe received by the fraction ethyl acetate. The concentration of the ethanolic extract andthe fraction of ethyl acetate that was used were 2; 4; 8; 16 ug/mL and isolat-1 that is:0.8; 1.6; 3.2; and 6.4 ug/mL.Results of the research showed that all the treatments had the activity asscavenging the free radical. Results of the analysis statistika with the Kruskal Wallismethod in the level of the confident 95% that was followed by the test Mann Whitneyshowed the existence of the difference of the activity of the capture of the free radicalwho was significant between respectively the treatment group. The conclusion from thisresearch was the value ES50 ethanalic extract (15.64 ug/mL) bigger than the factionethyl acetate fraction and higher (13.948 ug/mL) value of ethanalic extract was thanisolat 1 (3.961 g/mL).

EFEK HEPATOPROTEKTIF EKSTRAK METANOL JAHE MERAH (Zingiber officinale Roscoe) PADA MENCIT JANTAN YANG DIINDUKSI CCl4 Saiful Bachri, Moch.
PHARMACIANA Vol 1, No 2: November 2011
Publisher : PHARMACIANA

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Ekstrak MeOH jahe merah (Zingiber officinale Roscoe) telah diteliti efek hepatoprotektif pada dosis 100 mg/kgBB dan 200 mg/kgBB dengan menggunakan metode induksi CCl4. Mencit jantan galur Swiss (25±1,5 g) diberi perlakuan dengan jahe merah (100 mg/kgBB dan 200 mg/kgBB) dan Sillymarin (100 mg/kgBB) selama dua minggu sebelum diinduksi CCl4, 0,5 ml/kgBB secara intraperitonial. Setelah 24 jam mencit dibunuh dan diambil darah melalui vena porta untuk diuji aktivitas SGPT dan SGOT. Hasil penelitian menunjukkan bahwa aktivitas SGPT dari ekstrak MeOH jahe merah dengan dosis 100 mg/kgBB dan 200 mg/kgBB, Sillymarin, kontrol, dan normal berturut turut, (34,51±5,3427) (38±4,28) (27,26±1,06) (36,61±1,87) dan 25,37±2,01 IU/L. Sedangkan aktivitas SGOT dari Ekstrak MeOH jahe merah dengan dosis 100 mg/kgBB dan 200 mg/kgBB, Sillymarin, kontrol dan kelompok Normal berturut turut, (88,88±0,94) (83,88±3,91) (83,99±7,24) (92,97±8,16) (82,99±3,97)U/L. Ekstrak MeOH jahe merah dosis 200 mg/kgBB dan Sillymarin secara signifikan (p < 0,05) dapat menurunkan aktivitas SGPT dan SGOT. Dari hasil penelitian menunjukkan bahwa ekstrak MeOH jahe merah mempunyai efek hepatoprotektif.

EFEK EKSTRAK ETANOL RIMPANG TEMUGIRING (Curcuma heyneana val) TERHADAP KADAR TRIGLISERIDA Widyaningsih, Wahyu
PHARMACIANA Vol 1, No 1: Mei 2011
Publisher : PHARMACIANA

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Telah dilakukan penelitian tentang efek ekstrak etanol rimpang temugiring terhadap kadar trigliserida serum darah tikus. Penelitian ini menggunakan 28 ekor tikus jantan galur Wistar dengan berat badan antara 150-200 gram yang berumur 2 -3 bulan.Tikus dibagi menjadi 7 kelompok perlakuan dan setiap kelompok terdiri atas 4 ekor tikus. Kelompok I (Kontrol normal) mendapat perlakuan diet standar (BR II) dan air minum, kelompok II (Kontrol negatif) yang diberi perlakuan diet standar, diet lemak tinggi, dan air minum, kelompok III (Kontrol pensuspensi) yang diberi perlakuan diet standar, diet lemak tinggi, larutan CMC Na dan air minum, kelompok IV (Kontrol positif) yang diberi diet standar, diet lemak tinggi, suspensi gemfibrosil dosis 0,9 mg./kgBB dan air minum, kelompok V, VI, VII, diberikan perlakuan peroral dengan ekstrak etanol temugiring dosis 10 mg /kgBB, 20 mg /kgBB, dan 40 mg/kgBB.. Peningkatan kadar trigliserida diberikan dengan diet lemak tinggi (5 gram lemak sapi dan 10 gram kuning telur) dalam sediaan emulsi pada periode ke-2. Perlakuan ekstrak etanol temugiring diberikan setelah keadaan hipertrigliserida..Penetapan kadar trigliserida dengan metode GPO (Glycerol-3-Phosphate Oxidase). Hasil penelitian menunjukkan bahwa pemberian ekstrak etanol temugiring selama 2 minggu berturut-turut dapat menurunkan kadar trigiserida

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