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Journal of Mathematical and Fundamental Sciences
ISSN : 23375760     EISSN : 23385510     DOI : https://doi.org/10.5614/j.math.fund.sci.
Core Subject : Science, Education,
Journal of Mathematical and Fundamental Sciences welcomes full research articles in the area of Mathematics and Natural Sciences from the following subject areas: Astronomy, Chemistry, Earth Sciences (Geodesy, Geology, Geophysics, Oceanography, Meteorology), Life Sciences (Agriculture, Biochemistry, Biology, Health, Medical, Pharmacy), Mathematics, Physics, and Statistics.
Articles 626 Documents
Preliminary Studies of Cassava Leaves’ Ability to Remove Dyes from Water Chairunnisa, Chairunnisa; Lisafitri, Yuni
Journal of Mathematical and Fundamental Sciences Vol. 52 No. 1 (2020)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2020.52.1.5

Abstract

Low-cost adsorbents from cassava leaves (CLP) were prepared by simply washing the leaf powder with deionized water. The adsorption of methylene blue (MB) from the aqueous solution was measured in order to examine the adsorbent performance. The effect of the pH of the solution was studied by varying pH from 2 to 10. The kinetics of MB adsorption onto CLP followed the pseudo-second-order kinetic model with a k-value of 0.087907 g mg-1 min-1 and 0.094081 g mg-1 min-1 for CLP before and after washing, respectively. The adsorption isotherm for both adsorbents followed the Langmuir isotherm model with qm values of 178.5 mg g-1 and 243.9 mg g-1. The existence of disturber ions was investigated by adding NaCl into the MB solutions at a variety of concentrations.
Effects of Conditioned Medium of Co-Culture IL-2 Induced NK Cells and Human Wharton’s Jelly Mesenchymal Stem Cells (hWJMSCs) on Apoptotic Gene Expression in a Breast Cancer Cell Line (MCF-7) Widowati, Wahyu; Jasaputra, Diana Krisanti; Onggowidjaja, Philips; Sumitro, Sutiman Bambang; Widodo, Mochammad Aris; Afifah, Ervi; Rihibiha, Dwi Davidson; Rizal, Rizal; Amalia, Annisa; Kusuma, Hanna Sari Widya; Murti, Harry; Bachtiar, Indra
Journal of Mathematical and Fundamental Sciences Vol. 51 No. 3 (2019)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2019.51.3.1

Abstract

Breast cancer (BC) is the most prevalent type of cancer among women and one of the major causes of cancer mortality in women. Metastasis in breast cancer (BC) occurs due to immunosurveillance deficiency, including impairment of natural killer (NK) cell maturation. Conditioned medium (CM) from human Wharton's jelly mesenchymal stem cells (hWJMSC-CM) is known to possess anticancer activity. The CM of co-culture of human recombinant IL-2 treated NK cells and hWJMSCs is expected to boost anticancer activity toward BC cells which can be analyzed from the effect of CM towards secretion of effector molecules and expression of BC cell apoptosis-related genes, and cytotoxic granules in human recombinant IL-2 treated NK (IL-2 NK) and hWJMSCs (IL-2 hWJMSCs). TNF-α, IFN-γ, perforin, granzyme were measured by ELISA, while the inhibition of cell proliferation was measured by MTS assay and BC cell apoptosis by flow cytometry and apoptotic gene expression by RTPCR. CM from co-cultured hWJMSCs and IL-2 NK cells inhibited NK and BC cell proliferation, increased expression of Bax and p53 and decreased the number of Bcl-2 in BC cells. In conclusion, CM of co-culture IL-2 treated NK cells and hWJMSCs induce apoptosis in BC cells as indicated by increased Bax and p53 expression and decreased Bcl-2 expression. 
Effects of Root Extract of Ruellia tuberosa L. on Kidneys of Diabetic Rats Safitri, Anna; Srihardyastutie, Arie; Roosdiana, Anna; Aulanni’am, Aulanni’am; Octaviana, Eva Nur Laili
Journal of Mathematical and Fundamental Sciences Vol. 51 No. 2 (2019)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2019.51.2.3

Abstract

The aim of this research was to study the antidiabetic activity of root extract of Ruellia tuberosa L. on rats (Rattus novergicus) induced by multiple low doses of streptozotocin. The parameters investigated were blood glucose levels, protease activities, and the histopathologic profiles of the kidneys. Three groups of rats, i.e. control, diabetic, and treatment, were used. R. tuberosa L. extracts were given orally for treatment at a dose of 250 mg/kg body weight per day for 21 consecutive days. The induced diabetes group treated with root extract of R. tuberosa L. (group III) had 60.3% lower glucose levels (119 mg/dL) compared to the group with induced diabetes only. Moreover, antidiabetic activity of R. tuberosa L extract was evidenced by the 55% lower protease activity in the treatment group compared to the untreated diabetic group. Finally, a positive effect from root extract of R. tuberosa L. was shown from the less damaged renal glomerulus and smaller gap between extracellular matrices and epithelium cells in the histopathologic profiles of the kidneys in the extract treatment group. These results show the potential of root extract of R. tuberosa L. as a natural product anti-diabetic agent.
Polyelectrolyte Complex (PEC) of the Alginate-Chitosan Membrane for Immobilizing Urease Hermanto, Dhony; Mudasir, Mudasir; Siswanta, Dwi; Kuswandi, Bambang; Ismillayli, Nurul
Journal of Mathematical and Fundamental Sciences Vol. 51 No. 3 (2019)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2019.51.3.8

Abstract

PEC of the alginate-chitosan membrane as supporting material for immobilizing urease was produced. This study aimed to develop a supporting material for enzyme immobilization that has high stability, a fast response time and an easy and relatively inexpensive preparation procedure. An alginate-chitosan PEC membrane was produced by reacting alginate hydrosol and chitosan (1:1 in mass) at pH 5.28, followed by mixing and drying at room temperature. The FTIR spectra, XRD patterns and SEM assay confirmed that alginate-chitosan PEC was obtained. The color change of the BTB indicator proved that urease was trapped in the cavities of the alginate-chitosan PEC membrane while the immobilized urease still showed catalytic activity. Thus, the membrane of alginate-chitosan PEC has good characteristics as a matrix for urease immobilization.
A New Type of Coincidence and Common Fixed-Point Theorems for Modified 𝛂-Admissible 𝓩-Contraction Via Simulation Function Arora, Sahil; Kumar, Manoj; Mishra, Sanjay
Journal of Mathematical and Fundamental Sciences Vol. 52 No. 1 (2020)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2020.52.1.3

Abstract

In this manuscript, we introduce the concept of modified α-admissible contraction with the help of a simulation function and use this concept to establish some coincidence and common fixed-point theorems in metric space. An illustrative example that yields the main result is given. Also, several existing results within the frame of metric space are established. The main theorem was applied to derive the coincidence and common fixed-point results for α-admissible 𝒵-contraction.
Back Matter Vol. 50 No. 2, 2018 Fundamental Sciences, Journal of Mathematical and
Journal of Mathematical and Fundamental Sciences Vol. 50 No. 2 (2018)
Publisher : Institute for Research and Community Services (LPPM) ITB

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Abstract

Cytotoxic Activities of Extracts and Isolated Compounds of Some Potential Sumatran Medicinal Plants against MCF-7 and HSC-3 Cell Lines Andania, Meiridha Mutiara; Ismed, Friardi; Taher, Muhammad; Arief Ichwan, Solachuddin Jauhari; Bakhtiar, Amri; Arbain, Dayar
Journal of Mathematical and Fundamental Sciences Vol. 51 No. 3 (2019)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2019.51.3.2

Abstract

In continuation of our study of Sumatran plants and the bioactivity of their constituents, Stereocaulon halei Lamb (Stereocaulaceae) was extracted and isolated to obtain atranorin (1), lobaric acid (6), and methyl-β-orcinol carboxylate (9). We also prepared methanolic extracts of some Sumatran medicinal plants, i.e. Alpinia denticulata, Alpinia malaccensis, Alpinia submutica, Curcuma zedoaria, Centella asiatia, Mangifera indica, Piper crocatum, Mussaenda frondosa, together with previously isolated compounds, i.e. crocatin A (2) and crocatin B (3) from P. crocatum, curcumin (4) from Curcuma longa, demethoxymatteucinol (5) from Sphaerostephanos polycarpus, mangiferin (7) from M. indica, methyl caffeate (8) from Balanophora elongata, tiliroside (10) from Guazuma ulmifolia, and usnic acid from Usnea sp (11). These extracts and compounds were tested for their cytotoxicity against MCF-7 and HSC-3 cell lines by MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). It was found that the IC50 value of atranorin (1), lobaric acid (6), methyl-β-orcinol carboxylate (9), and methanolic extract of A. submutica towards the MCF-7 cell line was 208.20 µM, 172.05 µM, 382.60 µM and 70.95 µg/mL, respectively. The IC50 value of lobaric acid (6) and methyl-β-orcinol carboxylate (9) against the HSC-3 cell line was 88.92 µM and 260.09 µM, respectively. The other extracts did not show significant cytotoxicity.
Front Matter Vol. 50 No. 2, 2018 Fundamental Sciences, Journal of Mathematical and
Journal of Mathematical and Fundamental Sciences Vol. 50 No. 2 (2018)
Publisher : Institute for Research and Community Services (LPPM) ITB

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Abstract

Donsker’s Delta Functional of Stochastic Processes with Memory Suryawan, Herry Pribawanto
Journal of Mathematical and Fundamental Sciences Vol. 51 No. 3 (2019)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2019.51.3.5

Abstract

A class of stochastic processes with memory within the framework of the Hida calculus was studied. It was proved that the Donsker delta functionals of the processes are Hida distributions. Furthermore, the probability density function of the processes and the chaos decomposition of the Donsker delta functional were derived. As an application, the existence of the renormalized local times in an arbitrary dimension of the Riemann-Liouville fractional Brownian motion as a white noise generalized function was proved.
Cover Vol. 50 No. 2, 2018 Fundamental Sciences, Journal of Mathematical and
Journal of Mathematical and Fundamental Sciences Vol. 50 No. 2 (2018)
Publisher : Institute for Research and Community Services (LPPM) ITB

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