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INDONESIA
Journal of Mathematical and Fundamental Sciences
Published by Institut Teknologi Bandung
ISSN : 23375760     EISSN : 23385510     DOI : -
Core Subject : Education,
Mathematics
Journal of Mathematical and Fundamental Sciences welcomes full research articles in the area of Mathematics and Natural Sciences from the following subject areas: Astronomy, Chemistry, Earth Sciences (Geodesy, Geology, Geophysics, Oceanography, Meteorology), Life Sciences (Agriculture, Biochemistry, Biology, Health, Medical, Pharmacy), Mathematics, Physics, and Statistics.
Arjuna Subject : -
Articles 588 Documents
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Cover Vol. 49 No. 3, 2017 Fundamental Sciences, Journal of Mathematical and
Journal of Mathematical and Fundamental Sciences Vol 49, No 3 (2017)
Publisher : ITB Journal Publisher, LPPM ITB

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Abstract

Front Matter Vol. 51 No. 2, 2019 JMFS, JMFS
Journal of Mathematical and Fundamental Sciences Vol 51, No 2 (2019)
Publisher : ITB Journal Publisher, LPPM ITB

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Abstract

GROWTH OF HUMAN DERMAL FIBROBLASTS ON POLYVINYL ALCOHOL-SILK FIBROIN NANOFIBER SCAFFOLD Giovanni, Regina; Wibowo, Untung Ari; Judawisastra, Hermawan; Barlian, Anggraini
Journal of Mathematical and Fundamental Sciences Vol 51, No 3 (2019)
Publisher : ITB Journal Publisher, LPPM ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2019.51.3.7

Abstract

Skin tissue engineering is a developing technology to heal severe wounds. Combining polyvinyl alcohol (PVA) and silk fibroin (SF) nanofibers is a promising method of developing a skin scaffold because the resulting structure mimics collagen fibers. The aim of this research was to study the growth of human dermal fibroblasts (HDF) on a polyvinyl alcohol-silk fibroin (PVA-SF) nanofiber scaffold that was produced by electrospinning. Morphological characterization and chemical analysis of the scaffold were performed by scanning electron microscopy (SEM), Fourier transform infrared spectrophotometry (FTIR), and contact angle measurement. The biocompatibility of the scaffold was tested by MTT cytotoxicity assay, SEM analysis, adherence ratio calculation, and analysis of the HDF growth curve for 9 days. The FTIR results confirmed the presence of SF and PVA. The average fiber diameter and pore size of the PVA scaffold were greater than those of the PVA-SF scaffold. Both scaffolds had hydrophilic properties and were not cytotoxic. Thus, HDF can attach and grow on both types of scaffold better than HDF seeded on a polystyrene plate. In conclusion, the addition of SF to the PVA nanofibers caused bead formation, which affected the substrate topography, decreased hydrophilicity and also decreased the fiber diameter and pore size in the nanofiber scaffold compared to the PVA nanofiber scaffold without SF addition. SF addition increases cell attachment to the nanofiber scaffold and has potential to facilitate HDF cell growth.
B-EMISSION STARS IN SOUTHERN SKY OBSERVED IN BOSSCHA OBSERVATORY: SPECTROSCOPIC STUDY OF Hα SPECTRAL LINE VARIABILITY Aprilia, Aprilia; Malasan, Hakim Luthfi; Ramadhania, Geavani Eva; Jatmiko, Agus Triono Puri; Irfan, Mochamad; Ramadhan, Dhimaz Gilang; Istiqomah, Ade Nur; Akbar, Evan Irawan
Journal of Mathematical and Fundamental Sciences Vol 51, No 3 (2019)
Publisher : ITB Journal Publisher, LPPM ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2019.51.3.3

Abstract

H? line variations of 8 B-emission (Be) stars are presented. Stars that are listed in the Bright Star Catalogue were observed in 2009 at the Bosscha Observatory, Lembang, Indonesia. It was found that 4 stars showed phase changing from Be double-peaked to Be single-peaked emission line profiles, 1 showed single-peaked to double-peaked profiles, 1 showed double-peaked to B-normal, while two other stars did not show phase changing. The stars also showed variations in the V/R and E/C values, which represent the strength of the emission lines. The phase changes were detected from a comparison of the observed data to the current data in the BeSS database.
DONSKER’S DELTA FUNCTIONAL OF STOCHASTIC PROCESSES WITH MEMORY Suryawan, Herry Pribawanto
Journal of Mathematical and Fundamental Sciences Vol 51, No 3 (2019)
Publisher : ITB Journal Publisher, LPPM ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2019.51.3.5

Abstract

A class of stochastic processes with memory within the framework of the Hida calculus was studied. It was proved that the Donsker delta functionals of the processes are Hida distributions. Furthermore, the probability density function of the processes and the chaos decomposition of the Donsker delta functional were derived. As an application, the existence of the renormalized local times in an arbitrary dimension of the Riemann-Liouville fractional Brownian motion as a white noise generalized function was proved.
CYTOTOXIC ACTIVITIES OF EXTRACTS AND ISOLATED COMPOUNDS OF SOME POTENTIAL SUMATRAN MEDICINAL PLANTS AGAINST MCF-7 AND HSC-3 CELL LINES Andania, Meiridha Mutiara; Ismed, Friardi; Taher, Muhammad; Arief Ichwan, Solachuddin Jauhari; Bakhtiar, Amri; Arbain, Dayar
Journal of Mathematical and Fundamental Sciences Vol 51, No 3 (2019)
Publisher : ITB Journal Publisher, LPPM ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2019.51.3.2

Abstract

In continuation of our study of Sumatran plants and the bioactivity of their constituents, Stereocaulon halei Lamb (Stereocaulaceae) was extracted and isolated to obtain atranorin (1), lobaric acid (6), and methyl-?-orcinol carboxylate (9). We also prepared methanolic extracts of some Sumatran medicinal plants, i.e. Alpinia denticulata, Alpinia malaccensis, Alpinia submutica, Curcuma zedoaria, Centella asiatia, Mangifera indica, Piper crocatum, Mussaenda frondosa, together with previously isolated compounds, i.e. crocatin A (2) and crocatin B (3) from P. crocatum, curcumin (4) from Curcuma longa, demethoxymatteucinol (5) from Sphaerostephanos polycarpus, mangiferin (7) from M. indica, methyl caffeate (8) from Balanophora elongata, tiliroside (10) from Guazuma ulmifolia, and usnic acid from Usnea sp (11). These extracts and compounds were tested for their cytotoxicity against MCF-7 and HSC-3 cell lines by MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). It was found that the IC50 value of atranorin (1), lobaric acid (6), methyl-?-orcinol carboxylate (9), and methanolic extract of A. submutica towards the MCF-7 cell line was 208.20 µM, 172.05 µM, 382.60 µM and 70.95 µg/mL, respectively. The IC50 value of lobaric acid (6) and methyl-?-orcinol carboxylate (9) against the HSC-3 cell line was 88.92 µM and 260.09 µM, respectively. The other extracts did not show significant cytotoxicity.
BACK MATTER VOL. 51 NO. 3, 2019 JMFS, JMFS
Journal of Mathematical and Fundamental Sciences Vol 51, No 3 (2019)
Publisher : ITB Journal Publisher, LPPM ITB

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Abstract

EFFECTS OF CONDITIONED MEDIUM OF CO-CULTURE IL-2 INDUCED NK CELLS AND HUMAN WHARTON’S JELLY MESENCHYMAL STEM CELLS (HWJMSCS) ON APOPTOTIC GENE EXPRESSION IN A BREAST CANCER CELL LINE (MCF-7) Widowati, Wahyu; Jasaputra, Diana Krisanti; Onggowidjaja, Philips; Sumitro, Sutiman Bambang; Widodo, Mochammad Aris; Afifah, Ervi; Rihibiha, Dwi Davidson; Rizal, Rizal; Amalia, Annisa; Kusuma, Hanna Sari Widya; Murti, Harry; Bachtiar, Indra
Journal of Mathematical and Fundamental Sciences Vol 51, No 3 (2019)
Publisher : ITB Journal Publisher, LPPM ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2019.51.3.1

Abstract

Breast cancer (BC) is the most prevalent type of cancer among women and one of the major causes of cancer mortality in women. Metastasis in breast cancer (BC) occurs due to immunosurveillance deficiency, including impairment of natural killer (NK) cell maturation. Conditioned medium (CM) from human Wharton?s jelly mesenchymal stem cells (hWJMSC-CM) is known to possess anticancer activity. The CM of co-culture of human recombinant IL-2 treated NK cells and hWJMSCs is expected to boost anticancer activity toward BC cells which can be analyzed from the effect of CM towards secretion of effector molecules and expression of BC cell apoptosis-related genes, and cytotoxic granules in human recombinant IL-2 treated NK (IL-2 NK) and hWJMSCs (IL-2 hWJMSCs). TNF-?, IFN-?, perforin, granzyme were measured by ELISA, while the inhibition of cell proliferation was measured by MTS assay and BC cell apoptosis by flow cytometry and apoptotic gene expression by RTPCR. CM from co-cultured hWJMSCs and IL-2 NK cells inhibited NK and BC cell proliferation, increased expression of Bax and p53 and decreased the number of Bcl-2 in BC cells. In conclusion, CM of co-culture IL-2 treated NK cells and hWJMSCs induce apoptosis in BC cells as indicated by increased Bax and p53 expression and decreased Bcl-2 expression. 
FRONT MATTER VOL. 51 NO. 3, 2019 JMFS, JMFS
Journal of Mathematical and Fundamental Sciences Vol 51, No 3 (2019)
Publisher : ITB Journal Publisher, LPPM ITB

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Abstract

POLYELECTROLYTE COMPLEX (PEC) OF THE ALGINATE-CHITOSAN MEMBRANE FOR IMMOBILIZING UREASE Hermanto, Dhony; Mudasir, Mudasir; Siswanta, Dwi; Kuswandi, Bambang; Ismillayli, Nurul
Journal of Mathematical and Fundamental Sciences Vol 51, No 3 (2019)
Publisher : ITB Journal Publisher, LPPM ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2019.51.3.8

Abstract

PEC of the alginate-chitosan membrane as supporting material for immobilizing urease was produced. This study aimed to develop a supporting material for enzyme immobilization that has high stability, a fast response time and an easy and relatively inexpensive preparation procedure. An alginate-chitosan PEC membrane was produced by reacting alginate hydrosol and chitosan (1:1 in mass) at pH 5.28, followed by mixing and drying at room temperature. The FTIR spectra, XRD patterns and SEM assay confirmed that alginate-chitosan PEC was obtained. The color change of the BTB indicator proved that urease was trapped in the cavities of the alginate-chitosan PEC membrane while the immobilized urease still showed catalytic activity. Thus, the membrane of alginate-chitosan PEC has good characteristics as a matrix for urease immobilization.

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