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Global Medical & Health Communication (GMHC)
ISSN : 23019123     EISSN : 24605441     DOI : -
Core Subject : Health,
The Global Medical & Health Communication (GMHC) is journal that publishes research articles of medical and health published every 4 (four) months (April, August, and December). Articles are original research that needs to be disseminated and written in English. Subjects suitable for publication include, but are not limited to the following fields of anesthesiology and intensive care, biochemistry, biomolecular, cardiovascular, child health, dentistry, dermatology and venerology, epidemiology, geriatric, histopathology, internal medicine, nutrition, obstetrics and gynecology, occupational health, ophthalmology, oral biology, orthopedics and traumatology, otorhinolaryngology, pharmacology, pharmacy, preventive medicine, public health, pulmonology, radiology, and reproductive health.
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Articles 277 Documents
Hyperferritinemia Correlated with Activated Population of Natural Killer Cells in Pediatric Major β-Thalassemia Patients Cahyadi, Adi Imam; Ghozali, Mohammad; Ghrahani, Reni; Reniarti, Lelani; Panigoro, Ramdan
Global Medical & Health Communication (GMHC) Vol 9, No 1 (2021)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v9i1.6346

Abstract

Natural killer (NK) cells act both as cytotoxic and cytokine producers in the innate immune response. Hyperferritinemia resulting from a routine blood transfusion as a specific treatment in major β-thalassemia patients may disturb the cellular immune system’s harmony. This study aims to investigate the correlation between hyperferritinemia and the NK cell subsets in major β-thalassemia settings. Pediatric major β-thalassemia patients who routinely received a blood transfusion at Dr. Hasan Sadikin General Hospital in 2016 were included in this cross-sectional study. Blood samples were treated with the monoclonal antibody of CD3, CD56, and CD16 to count the NK cells subsets as CD56bright, CD56dim, and CD16+ using flowcytometry. CD69+ used as an activation marker. The median fluorescence intensity (MFI) of CD56, CD16, and CD69 was measured. Total iron-binding capacity (TiBC), ferritin, and serum iron level examined as iron status. A Spearman correlation test was used for statistical analysis. Fifty-five blood samples were obtained for analysis. This study reveals that the percentage of CD3− lymphocyte population was correlated with the ferritin levels (r=−0.45, p=0.0009). Positive correlation was revealed between activated population (CD69+) of CD56bright and CD56dim NK cell subsets and hyperferritinemia [(r=0.353, p=0.008) and (r=0.355, p=0.008)]. The activated CD56bright cells was associated with ferritin level (r=0.353, p=0.008) and TiBC (r=0.334, p=0.018). Hyperferritinemia in pediatric major β-thalassemia patients may influence NK cell subsets' balance population, particularly the CD56bright and CD56dim NK cell subsets, then alter their immune response to pathogens. KORELASI ANTARA HIPERFERITINEMIA DAN SEL NATURAL KILLER TERAKTIVASI PADA ANAK DENGAN TALASEMIA BETA MAYORSel-sel natural killer (NK) telah diketahui memiliki peran sitotoksik dan dalam produksi sitokin pada respons imun bawaan. Hiperferitinemia merupakan hasil dari transfusi darah rutin yang dijalani sebagai terapi utama pada talasemia mayor. Penelitian ini bertujuan mempelajari hubungan hiperferitinemia dan sel NK pada talasemia beta mayor. Penelitian potong lintang ini melibatkan anak dengan talasemia beta mayor yang secara rutin menerima transfusi darah di RSUP Dr. Hasan Sadikin selama tahun 2016. Sampel darah diberi marker CD3, CD56, dan CD16 untuk menghitung subset sel NK sebagai CD56bright, CD56dim, dan CD16+ menggunakan flowcytometry. CD69+ digunakan sebagai penanda aktivasi. Median fluorescence intensity (MFI) CD56, CD16, dan CD69 diukur. Kadar TiBC, ferritin, dan Fe serum diperiksa sebagai status besi. Uji korelasi Spearman digunakan pada analisis statistik. Analisis dilakukan terhadap 55 sampel darah anak dengan talasemia. Penelitian ini mendapatkan populasi limfosit CD3 berkorelasi dengan kadar feritin (r=−0,45; p=0,0009). Korelasi positif didapatkan pada populasi teraktivasi (CD69+) dari subset sel CD56bright dan CD56dim NK serta hiperferitinemia [(r=0,353; p=0,008) dan (r=0,355; p=0,008)]. Sel CD56bright teraktivasi berkorelasi dengan kadar feritin (r=0,353; p=0,008) dan TiBC (r=0,334; p=0,018). Hiperferitinemia pada anak dengan talasemia mayor dapat memengaruhi populasi sel NK, khususnya pada subset CD56bright dan CD56dim sehingga berpengaruh pada respons imun terhadap patogen.
D-Dimer Level with Cerebral Venous Sinus Thrombosis (CVST) Occurrence Using Digital Subtraction Angiography (DSA) Putra, Afdi Arahim; Buchori, Eppy; Hilman, Hilman; Amalia, Lisda
Global Medical & Health Communication (GMHC) Vol 7, No 3 (2019)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v7i3.5341

Abstract

Cerebral venous sinus thrombosis (CVST) is a cerebrovascular disease in the form of occlusion due to thrombus in the venous and cerebral sinuses. It rarely occurs and has varied clinical symptoms and radiological features and challenging to diagnose. D-dimer used as a diagnostic marker for cases of venous thromboembolism, with a sensitivity of around 90–92%. However, the specificity is not too high (70–73%) because it can also increase in other conditions. Digital subtraction angiography (DSA) is a gold standard examination to establish the diagnosis of CVST. The purpose of this study was to determine the relationship between the D-dimer level and CVST using DSA at Dr. Hasan Sadikin General Hospital in Bandung. This study used an observational analytic method with a case-control study design using retrospective data from medical records at Dr. Hasan Sadikin General Hospital in January 2017–August 2019. The research subjects divided into two groups, namely the high D-dimer levels and the normal/low D-dimer level. Forty people meet the inclusion criteria, ages averaging from 44.77±14.40 years, and consists of 9 male patients (22%) and 31 women patients (78%). For normal/low D-dimer levels 20 patients (50%) and high D-dimer levels 20 patients (50%). Statistical test results measuring D-dimer and CVST levels found a significant relationship (p<0.05). In conclusion, there is a relationship between D-dimer levels with CVST events that have been done by DSA. The higher the D-dimer level, the higher the suspicion of CVST. KADAR D-DIMER DENGAN KEJADIAN CEREBRAL VENOUS SINUS THROMBOSIS (CVST) MENGGUNAKAN DIGITAL SUBTRACTION ANGIOGRAPHY (DSA)Penyakit cerebral venous sinus thrombosis (CVST) merupakan penyakit serebrovaskular berupa oklusi akibat trombus di saluran vena dan sinus serebral yang jarang terjadi dengan gejala klinis dan gambaran radiologis yang bervariasi, serta sangat sulit untuk didiagnosis. D-dimer dapat dijadikan sebagai penanda diagnostik bagi kasus-kasus tromboembolisme vena dengan sensitivitas 90–92%, namun spesifisitasnya tidak terlalu tinggi (70–73%) karena dapat juga meningkat pada kondisi lain. Digital subtraction angiography (DSA) merupakan pemeriksaan baku emas untuk menegakkan diagnosis CVST. Tujuan penelitian ini mengetahui hubungan antara kadar D-dimer dan CVST menggunakan DSA di RSUP Dr. Hasan Sadikin Bandung. Penelitian ini merupakan observasional analitik dengan rancangan kasus kontrol menggunakan data retrospektif dari rekam medis di RSUP Dr. Hasan Sadikin Bandung pada bulan Januari 2017–Agustus 2019. Subjek penelitian dibagi menjadi 2 kelompok, yaitu kelompok D-dimer tinggi dan kelompok D-dimer normal/rendah. Hasil penelitian didapat 40 orang yang memenuhi kriteria inklusi, usia rerata 44,77±14,40 tahun yang terdiri atas pasien laki-laki 9 orang (22%) dan perempuan 31 orang (78%). Untuk kadar D-dimer kategori normal/rendah 20 orang (50%) dan tinggi 20 orang (50%). Hasil uji statistik mengukur kadar D-dimer dan CVST didapatkan hubungan yang bermakna (p<0.05). Simpulan, terdapat hubungan antara kadar D-dimer dan kejadian CVST yang telah dilakukan DSA. Semakin tinggi kadar D-dimer, semakin tinggi kecurigaan kejadian CVST.
Implementation of Sustainable Development Goals (SDGs) and Disaster Risk Reduction (DRR): a Case Study Davey, Peter
Global Medical & Health Communication (GMHC) Vol 7, No 3 (2019)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v7i3.5497

Abstract

Climate change adaptation and mitigation measures a complicated process and community livelihoods are being seriously impacted. The current local community reality is that climate change and associated disasters are becoming more intense, unpredictable, frequent and costly impacting on rural and urban areas. Disaster Risk Reduction is very important. United Nations General Assembly already set the global policy with the hope that the impact of future disaster events on the community is substantially reduced. Solutions to internal refugee crises start at the local level and require that everyone plays a part: every city, every neighbourhood including farming areas, and every individual can contribute. Leaders must create spaces where everyone can live in safety, become self-reliant, and contribute to and participate in their local community, and not allow people to shift into slum areas after disasters strike. The UNISDR suggests community’s use of the recovery, rehabilitation and reconstruction phases after a disaster to increase the resilience of nations and communities; through integrating disaster risk reduction measures into the restoration of physical infrastructure and societal systems, and into the revitalization of livelihoods, economies, and the environment.
VEGF-A and PD-L1 Immunoexpression Association with Meningioma Histopathology Grade Yunnica, Yunnica; Afiati, Afiati; Usman, Hermin Aminah; Hernowo, Bethy Surjawathy
Global Medical & Health Communication (GMHC) Vol 7, No 3 (2019)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v7i3.4202

Abstract

Histopathology grade of meningioma is one of the most common factors determining the prognosis and affects the risk of recurrence and aggressiveness of the tumor. Biological factors related to histopathological grade are vascular endothelial growth factor A (VEGF-A) and programmed death-ligand 1 (PD-L1). This research aimed to understand the association between VEGF-A and PD-L1 with meningioma histopathology grade. This is in vivo research on 60 paraffin blocks of meningioma cases at Dr. Hasan Sadikin General Hospital Bandung from April to November 2018. Paraffin block samples consist of grade I (30), grade II (15), and grade III (15) meningioma. Immunohistochemical staining of VEGF-A and PD-L1 performed to all samples. Data analyzed using the chi-square test with SPSS version 24.0 for Windows. The result shows a significant association between VEGF-A and PD-L1 immunoexpression with meningioma histopathology grade. PD-L1 is the most potent factor that influenced the histopathology grade of meningioma. The study concluded that the histopathology grade of meningiomas influenced by angiogenesis and immune checkpoints. VEGF-A and PD-L1 immunoexpression in meningioma considered as a factor that influences the aggressiveness of meningioma. HUBUNGAN IMUNOEKSPRESI VEGF-A DAN PD-L1 DENGAN DERAJAT HISTOPATOLOGI MENINGIOMADerajat histopatologi meningioma merupakan salah satu faktor yang paling umum menentukan prognosis serta memengaruhi risiko rekurensi dan agresivitas tumor. Faktor biologi yang berhubungan dengan derajat histopatologi adalah vascular endothelial growth factor A (VEGF-A) dan programmed death-ligand 1 (PD-L1). Penelitian ini bertujuan mengetahui hubungan imunoekspresi VEGF-A dan PD-L1 dengan derajat histopatologi meningioma. Penelitian in vivo dilakukan pada 60 blok parafin kasus meningioma di Departemen Patologi Anatomi RSUP Dr. Hasan Sadikin Bandung dari April hingga November 2018. Sampel blok parafin terdiri atas meningioma derajat I (30), derajat II (15), dan derajat III (15). Pulasan imunohistokimia VEGF-A dan PD-L1 dilakukan terhadap semua sampel. Data dianalisis menggunakan uji chi-square dengam SPSS versi 24.0 untuk Windows. Hasil penelitian menunjukkan bahwa terdapat hubungan yang signifikan antara VEGF-A dan PD-L1 dengan derajat histopatologi meningioma. PD-L1 merupakan faktor paling kuat yang memengaruhi derajat histopatologi meningioma. Simpulan penelitian ini adalah derajat histopatologi meningioma dipengaruhi oleh faktor angiogenesis dan immune check point. Imunoekspresi VEGF-A dan PD-L1 pada meningioma dapat dipertimbangkan sebagai faktor yang memengaruhi agresivitas meningioma.
Antioxidant and Anti-tyrosinase Activities of Aloe vera Rind and Gel Extracts Mahadi, Sonya Bonifacia; Handayani, Rr. Anisa Siwianti; Widowati, Wahyu; Wilsen, Wilsen; Dewani, Yunita; Fachrial, Edy; Lister, I Nyoman Ehrich
Global Medical & Health Communication (GMHC) Vol 7, No 3 (2019)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v7i3.4453

Abstract

Aging is a natural process in human that can be characterized by the appearance of black spot on the skin due to hyperpigmentation. Aging may occur due to an excessive amount of free radicals in the body. Antioxidants possess ability to capture free radicals and inhibit tyrosinase which induces skin aging. Aloe vera has been used in traditional medicine because it contains several bioactive compounds that act as antioxidant and prevent aging process. This study aims to determine phytochemical content, antioxidant activity and tyrosinase inhibition activity of Aloe vera rind (AVRE) and gel (AVGE) extract. This research was carried out at the laboratorium of Aretha Medika Utama-Biomolecular and Biomedical Research Center in Bandung city in September–November 2018. Phytochemical assay was determined using modified Farnsworth method. Antioxidant assay was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity and antiaging assay was obtained using tyrosinase inhibition assay. AVRE contains flavonoid, phenol, steroid, and alkaloid. Meanwhile, AVGE contains steroid and alkaloid. IC50 DPPH scavenging activity of AVRE was 113.18 µg/mL followed by AVGE was 291.96 µg/mL. IC50 tyrosinase inhibition activity of AVRE was 65.04 µg/mL followed by AVGE was 111.89 µg/mL. AVRE had more active DPPH scavenging activity and tyrosinase inhibition activity than AVGE. AKTIVITAS ANTIOKSIDAN DAN ANTITIROSINASE KULIT DAN DAGING LIDAH BUAYA (ALOE VERA)Penuaan merupakan proses alamiah pada manusia. Penuaan dapat terjadi akibat kadar radikal bebas yang tinggi di dalam tubuh. Antioksidan memiliki kemampuan memerangkap radikal bebas dan menghambat kerja enzim yang berperan dalam proses penuaan. Lidah buaya (Aloe vera) telah digunakan dalam pengobatan tradisional karena diketahui mengandung senyawa bioaktif yang bermanfaat dalam menangkal radikal bebas dan menghambat penuaan. Penelitian ini bertujuan mengetahui kandungan fitokimia dalam ekstrak etanol kulit lidah buaya (EKLB) dan ekstrak etanol daging lidah buaya (EDLB), mengetahui aktivitas antioksidan, pemerangkapan 2,2-difenil-1-pikrilhidrazil (DPPH), serta aktivitas antitirosinase EKLB dan EDLB. Penelitian ini dilakukan pada September–November 2018 di laboratorium Aretha Medika Utama Biomolecular and Biomedical Research Center (BBRC). Analisis fitokimia dilakukan menggunakan metode Farnsworth yang dimodifikasi. Aktivitas antioksidan dianalisis menggunakan metode pemerangkapan DPPH, sementara uji antipenuaan dilakukan menggunakan metode uji aktivitas antitirosinase. Hasil uji fitokimia menunjukkan EKLB mengandung flavonoid, fenol, steroid, dan alkaloid; sedangkan EDLB mengandung senyawa steroid dan alkaloid. EKLB dan EDLB memiliki aktivitas pemerangkapan DPPH dengan nilai IC50 secara berurutan 113,18 µg/mL dan 291,96 µg/mL. Penghambatan tirosinase EKLB dan EDLB dengan nilai IC50 secara berurutan 65,04 µg/mL dan 111,89 µg/mL. EKLB memiliki aktivitas antioksidan dan penghambatan tirosinase yang lebih baik dibanding dengan EDLB.
Impact of Integrated Reproductive Health Module Implementation on Junior High School Student Behavior Changes Handayani, Dini Saraswati; Mandiri, Ariyati; Aprillani, Irna Kurnia
Global Medical & Health Communication (GMHC) Vol 7, No 3 (2019)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v7i3.3202

Abstract

Socio-cultural changes, low understanding of religion, development of information technology, and limitation of appropriate information sources, causes sexual and reproductive behavior problems in adolescents. The solutions are through the application of an integrated reproductive health module as a teaching guide for teachers by using student center learning approach. The objectives of this study are to analyze the implementation effect of an integrated reproductive health module on changes in student behavior. This study using a quasi-experimental pretest-posttest design with control groups, which conducted from March to May 2017. The subject in this research is the students of class VII in 5 (five) Bandung city areas by inclusion and exclusion criteria. A total of 36 students from the five junior secondary schools as the research group received an integrated learning module, while 38 students from different classes in the same school as the control group using the reproductive health module based on the 2013 Curriculum. The data collection used questionnaires to assess behavior based on self-assessment, friends, and parents. The results of this study indicate that the interpersonal communication behavior increased by 5.74%, reproductive health behavior increased by 18.65%, and sexual behavior increased by 9.07%, with a significant difference compared to students who received the 2013 Curriculum (p<0.001). In conclusion, the implementation of the integrated reproductive health module had affected the student behavior change in maintaining reproductive health, sexual, and interpersonal communication. PENGARUH PENERAPAN MODUL PEMBELAJARAN KESEHATAN REPRODUKSI TERINTEGRASI TERHADAP PERUBAHAN PERILAKU SISWA SEKOLAH MENENGAH PERTAMAPerubahan sosial budaya, pemahaman agama yang rendah, perkembangan teknologi informasi, dan keterbatasan sumber informasi yang tepat menyebabkan permasalahan perilaku seksual dan kesehatan reproduksi pada remaja. Salah satu upaya yang dilakukan adalah melalui penerapan modul kesehatan reproduksi terintegrasi sebagai pedoman mengajar bagi guru dengan menggunakan pendekatan student center learning. Tujuan penelitian ini menganalisis pengaruh implementasi modul pembelajaran kesehatan reproduksi terintegrasi terhadap perubahan perilaku siswa. Penelitian ini menggunakan quasi-experimental pretest-posttest design with control groups yang dilakukan dari bulan Maret hingga Mei 2017. Subjek penelitian adalah siswa kelas VII di 5 (lima) wilayah Kota Bandung dengan kriteria inklusi dan eksklusi. Sebanyak 36 siswa dari lima sekolah menengah pertama sebagai kelompok perlakuan mendapatkan modul kesehatan reproduksi terintegrasi dan 38 siswa dari kelas yang berbeda di sekolah yang sama sebagai kelompok kontrol menggunakan materi kesehatan reproduksi berdasar atas Kurikulum 2013. Pengumpulan data menggunakan kuesioner penilaian perilaku oleh diri sendiri, teman, dan orangtua. Hasil menunjukkan bahwa perilaku komunikasi interpersonal siswa meningkat 5,74%, perilaku menjaga kesehatan reproduksi meningkat 18,65%, dan perilaku seksual sehat siswa meningkat 9,07% dengan perbedaan yang signifikan dibanding dengan siswa yang mendapatkan Kurikulum 2013 (p<0,001). Simpulan, penerapan modul pembelajaran kesehatan reproduksi terintegrasi berpengaruh terhadap perubahan perilaku kesehatan reproduksi siswa.
Phylogenetic Analysis of Culex tritaeniorhynchus and Culex vishnui Vector of Japanese Encephalitis Virus Astuti, Raden Roro Upiek Ngesti Wibawaning; Mulyaningsih, Budi; Soesilohadi, R.C. Hidayat; Nurcahyo, Raden Wisnu; Hadisusanto, Suwarno
Global Medical & Health Communication (GMHC) Vol 7, No 3 (2019)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v7i3.4051

Abstract

Culex tritaeniorhynchus and Culex vishnui are medically essential mosquitoes that transmit the Japanese encephalitis (JE) virus. There is less information about the recording data and research due to genetic character differences among them. The objective of this study was to examine the genetic variation of Cx. tritaeniorhynchus and Cx. vishnui in 3 sites of Central Java using polymerase chain reaction randomly amplified polymorphic DNA (PCR-RAPD). The study was done in January to November 2017 in Pekalongan city, Pekalongan regency, and Semarang regency. Adult female mosquitoes collected by human bite method. DNA of ten Cx. tritaeniorhynchus samples and fifteen samples of Cx. vishnui purified using DNA extraction kit. Furthermore, PCR amplification was conducted with 5 RAPD primers (OPA 11, 12, 15, 16, and 20) and would run into 2% gel electrophoresis for 45 minutes. Cluster analysis was using MVSPTM software (version 3.1). The results showed 213 genetic characters of Cx. vishnui, while 142 characters shown by Cx. tritaeniorhynchus. The dendrograms showed three distinct groups of Cx. vishnui from 2 sites of Pekalongan and one site of Semarang, while Cx. tritaeniorhynchus showed two distinct groups, which were 1 group from Pekalongan and 1 group from Semarang. Low genetic similarity (<10%) shown Cx. vishnui from Pekalongan city and Pekalongan district, and there was no genetic similarity in Cx. tritaeniorhynchus from Pekalongan and Semarang. It concluded that the polymorphism of Cx. tritaeniorhynchus and Cx. vishnui reached 100%. ANALISIS FILOGENETIK CULEX TRITAENIORHYNCHUS DAN CULEX VISHNUI VEKTOR VIRUS JAPANESE ENCEPHALITISNyamuk Culex tritaeniorhynchus dan Culex vishnui memiliki peran penting di bidang medis terutama dalam penularan virus Japanese  encephalitis (JE). Sampai saat ini data dan riset tentang karakter genetik vektor JE masih sangat terbatas. Penelitian ini bertujuan menjelaskan variasi genetik Cx. tritaeniorhynchus dan Cx. vishnui di 3 lokasi di Jawa Tengah berdasar polymerase chain reaction randomly amplified polymorphic DNA (PCR-RAPD). Studi ini dilakukan dari bulan Januari sampai November 2017 di Kota Pekalongan, Kabupaten Pekalongan, dan Kabupaten Semarang. Metode human bite digunakan untuk koleksi nyamuk. Ekstraksi DNA nyamuk dilakukan pada 10 ekor Cx. tritaeniorhynchus dan 15 ekor Cx. vishnui menggunakan kit ekstraksi DNA. Selanjutnya, diamplifikasi dengan 5 macam primer RAPD (OPA 11, 12, 15, 16, dan 20), serta dielektroforesis pada 2% agar selama 45 menit. Analisis klaster dilakukan menggunakan program MVSPTM (versi 3.1). Ditemukan 213 dan 142 karakter genetik masing-masing pada Cx. vishnui dan Cx. tritaeniorhynchus. Analisis dendogram menunjukkan 3 grup yang berbeda untuk Cx. vishnui, sedangkan untuk Cx. tritaeniorhynchus terdapat 2 grup yang berbeda, yaitu 1 grup dari Pekalongan dan 1 grup dari Semarang. Similaritas genetik yang rendah (<10%) ditunjukkan Cx. vishnui dari Kota Pekalongan dan Kabupaten Pekalongan, bahkan tidak ada persamaan genetik pada Cx. tritaeniorhynchus dari Pekalongan dengan Semarang. Disimpulkan bahwa polimorfisme Cx. tritaeniorhynchus dan Cx. vishnui mencapai 100%.
Relation between Vitamin D Level and Knowledge and Attitude Towards Sunlight Exposure among Asthma Outpatients in Surabaya Lorensia, Amelia; Suryadinata, Rivan Virlando; Amir, Gebriella Ayuni
Global Medical & Health Communication (GMHC) Vol 7, No 3 (2019)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v7i3.3094

Abstract

Asthma has become one of the health problems in the world. Asthma is characterized by chronic inflammation of the respiratory tract which leads to breathlessness, wheezing, and airflow limitation. Inflammatory reaction in asthma is related to inadequate vitamin D level. Vitamin D is a vitamin produced naturally by the body when exposed to sunlight that has immunomodulatory properties can reduce inflammation. Knowledge and positive attitude to sun exposure are necessary to prevent severe asthma attacks. This was a cross-sectional study involving 26 subjects in a private university in east Surabaya during January–June 2017 that was aimed to determine the relation between vitamin D and knowledge and attitude towards sunlight exposure. Data were collected by measuring the vitamin D level in blood serum and through the use of a questionnaire that consisted of two aspects, level of knowledge and attitude to sun exposure. Chi-square test was used to analyze the relationship between vitamin D level, knowledge, and attitude. No relationship was found between blood vitamin D level of asthma respondents and level of knowledge of sun exposure related to vitamin D (p=0.444, p>0.05). The same was also true for the relationship between blood vitamin D level of asthma respondents and attitude to sun exposure related to vitamin D (p=0.768, p>0.05). The closeness of the relationship between knolwedge and attitude was also relatively low (0.093). In conclusion, there is no correlation between vitamin D level, knowledge, and attitude. In addition, there is also no correlation between knowledge and attitude with low relationship between the two variables. HUBUNGAN KADAR VITAMIN D DENGAN PENGETAHUAN DAN SIKAP TENTANG PAPARAN SINAR MATAHARI PADA PASIEN ASMA RAWAT JALAN DI SURABAYAAsma telah menjadi masalah kesehatan di dunia. Asma ditandai oleh peradangan kronis pada saluran pernapasan yang menyebabkan sesak napas, mengi, dan keterbatasan aliran udara. Reaksi peradangan pada asma terkait dengan kadar vitamin D yang tidak memadai. Vitamin D merupakan vitamin yang diproduksi secara alami oleh tubuh ketika terkena sinar matahari yang memiliki sifat imunomodulator dapat mengurangi peradangan. Pengetahuan dan sikap positif terhadap paparan sinar matahari diperlukan untuk mencegah risiko keparahan asma. Penelitian ini menggunakan metode cross-sectional yang melibatkan 26 subjek di sebuah universitas swasta di Surabaya Timur pada Januari–Juni 2017 yang bertujuan menentukan hubungan vitamin D dengan pengetahuan dan sikap terhadap paparan sinar matahari. Data dikumpulkan dengan mengukur kadar vitamin D dalam serum darah dan melalui penggunaan kuesioner yang terdiri atas dua aspek, tingkat pengetahuan dan sikap terhadap paparan sinar matahari. Uji chi-square digunakan untuk menganalisis hubungan antara kadar vitamin D, pengetahuan, dan sikap. Tidak ada hubungan yang ditemukan antara kadar vitamin D darah responden asma dan tingkat pengetahuan paparan sinar matahari yang terkait dengan vitamin D (p=0,444; p>0,05). Hal yang sama juga berlaku untuk hubungan antara kadar vitamin D darah responden asma dan sikap terhadap paparan sinar matahari yang terkait dengan vitamin D (p=0,768; p>0,05). Kedekatan hubungan antara pengetahuan dan sikap juga relatif rendah (0,093). Simpulan, tidak ada hubungan antara kadar vitamin D, pengetahuan, dan sikap. Selain itu, juga tidak ada hubungan yang rendah antara pengetahuan dan sikap.
Hubungan Antara Reactive Oxygen Species (ROS), Superoxide Dismutase (SOD) dengan Protein α-Sinuklein-larut Air pada Batang Otak Tikus yang Diinduksi Rotenon Yulianti, Arief Budi; Sumarsono, Sony Heru; Ridwan, Ahmad; Yusuf, Ayda T
Global Medical & Health Communication (GMHC) Vol 3, No 2 (2015)
Publisher : Fakultas Kedokteran Universitas Islam Bandung

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Abstract

Abstrak Parkinson adalah salah satu penyakit neurodegeneratif dengan ganggunan gerak bila kematian neuron dopaminergik lebih dari 70 %. Paparan neurotoksin diduga menjadi penyebab terjadinya Parkinson sporadik. Tujuan penelitian ini adalah menentukan kondisi stres oksidatif pada batang otak tikus Wistar yang diinduksi rotenon. Metode: Penelitian eksperimental dengan menggunakan tikus Wistar jantan. Variabel bebas: kelompok tikus, lama perlakuan, waktu pengamatan, dan lokasi di batang otak. Variabel terikat: konsentari SOD, konsentrasi protein α-sinuklein-larut air, dan densitas ROS. Densitas ROS berbeda secara signifikan antara kelompok perlakuan (sig: 0,029), waktu pengamatan (sig: 0,0001), dan lokasi di batang otak (sig: 0,001). Konsentrasi SOD tidak berbeda secara signifikan antar kelompok perlakuan (sig:0,566), waktu pengamatan (sig:0,441) dan lokasi di batang otak (sig: 0,091). Konsentrasi protein α-sinuklein-larut air berbeda secara signifikan antar kelompok perlakuan (sig: 0,001), waktu pengamatan (sig: 0,001) tetapi tidak berbeda secara signifikan pada lokasi di batang otak (0,625). Densitas ROS relatif tertinggi pada hari ke-10 dan 40. Sementara itu konsentrasi SOD pada hari ke-10 dan 40 relatif rendah sedangkan konsentrasi protein α-sinuklein-larut air pada hari ke-10 relatif tinggi dibandingkan dengan hari ke-40. Dengan demikian dapat disimpulkan bahwa stres oksidatif pada batang otak tikus Wistar yang diinduksi rotenon berpengaruh pada struktur protein α-sinuklein.   Kata kunci: Batang otak, protein α-sinuklein, ROS, rotenon, SOD, stres oksidatif   Abstract Parkinson is the neurodegenerative disease with movement disordered, if the dopaminergic neurons dead more than 70%. Neurotoxins exposure is predicted cause sporadic Parkinson. The research aim is to determine oxidative stress stage in the brainstems Wistar rat’s treated-rotenone. Methods: An experimental study using male Wistar rats. The independent variable: groups of rats, long treatment, observation time, and location in the brainstem. The dependent variable: SOD concentration, concentration of protein α-synuclein-water soluble, and ROS density. ROS density significantly different among treatment groups (sig: 0,029), observation time (sig: 0.0001), and the location in the brainstem (sig: 0,001). SOD concentrations not significantly different among treatment groups (sig: 0.566), observation time (sig: 0.441) and the location in the brainstem (sig: 0.091). The concentration of protein α-synuclein-water soluble significantly different among treatment groups (sig: 0,001), observation time (sig: 0,001), but not significantly different at the location in the brainstem (0,625). ROS density relatively high at day 10 and 40. Meanwhile SOD concentration on day 10 and 40 are relatively low. And the concentration of α-synuclein protein-water soluble on day 10 is relatively higher than on day 40. The conclution is oxidative stress in the brainstem Wistar rat’s treated-rotenone effected on the protein α-synuclein structure Key word: α-synuclein protein, brainstem, oxidative stress, ROS, rotenone, SOD
Exploration of Methadone and HIV Treatment For Injecting Drug Users In West Java, Indonesia: Lessons from Practice Laere, Igor van; Hidayat, Teddy; Wisaksana, Rudi
Global Medical & Health Communication (GMHC) Vol 1, No 1 (2013)
Publisher : Fakultas Kedokteran Universitas Islam Bandung

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ABSTRACT Over the last decade, Indonesia became one of the fastest growing injecting drug user (IDU) driven HIV epidemics in Asia. Among strategies to prevent and control the HIV epidemic in Indonesia, methadone maintenance treatment (MMT) has been established and could become an entry point for HIV testing and treatment in IDUs. This study explored MMT and HIV treatment practices in West Java. An evaluation team visited six MMT clinics, interviewed staff and collected data on patient characteristics, methadone dose, and HIV testing and treatment practices. By October 2011, from 203 IDUs entering MMT (range 7-73 per clinic), 95% were male with the average age of 31 years (range 19-60 years), 92% had a senior high school or higher diploma, 47% had a regular income, and 55% were married. The mean methadone dose was 79 mg/day (range 13-208mg/day). About 85% of the MMT patients were tested for HIV, of whom 70% were found HIV positive (121/173), while 59% had a baseline CD4 count &gt; 200 cells/mm3 and 65% were receiving ART.  In conclusion, few IDUs entered MMT in West Java and among those who did; high HIV and ART rates were reported, stressing the need for active linking between harm reduction services and integrated MMT and HIV treatment for IDUs.   Key words: injecting drug user; methadone; HIV; ART; clinical guideline; Indonesia

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